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    5-MEMBERED HETEROCYCLIC COMPOUND
    3.
    发明公开
    5-MEMBERED HETEROCYCLIC COMPOUND 有权
    5-GLIEDRIGE HETEROCYCLISCHE VERBINDUNG

    公开(公告)号：EP2196459A1

    公开(公告)日：2010-06-16

    申请号：EP08833168.1

    申请日：2008-09-24

    申请人： Takeda Pharmaceutical Company Limited

    发明人： NISHIDA, Haruyuki ,  ARIKAWA, Yasuyoshi ,  HIRASE, Keizo

    IPC分类号： C07D233/64 ,  A61K31/381 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/506 ,  A61P1/00 ,  A61P1/04 ,  A61P35/00 ,  A61P43/00 ,  C07D233/68 ,  C07D277/28 ,  C07D333/20 ,  C07D333/22 ,  C07D403/04

    CPC分类号： C07D333/20 ,  C07D231/18 ,  C07D231/38 ,  C07D231/40 ,  C07D231/42 ,  C07D233/24 ,  C07D233/42 ,  C07D333/32 ,  C07D333/34 ,  C07D401/12 ,  C07D403/04 ,  C07D409/14 ,  C07D417/06 ,  C07D417/14

    摘要： Provided is a compound having a superior acid secretion suppressive action, which shows an antiulcer activity and the like.
    A compound represented by the formula (I) or a salt thereof:

    wherein ring A is a saturated or unsaturated 5-membered heterocycle containing, as a ring-constituting atom besides carbon atoms, at least one heteroatom selected from a nitrogen atom, an oxygen atom and a sulfur atom, the ring-constituting atoms X 1 and X 2 are the same or different and each is C or N, the ring-constituting atoms X 3 and X 4 are the same or different and each is C, N, O or S (provided that a pyrrole ring wherein X 1 is N is excluded from ring A), and when the ring-constituting atom X 3 or X 4 is C or N, each ring-constituting atom optionally has substituent(s) selected from an optionally substituted alkyl, an acyl, an optionally substituted hydroxy, an optionally substituted mercapto, an optionally substituted amino, a halogen, a cyano and a nitro;
    R 1 and R 2 are each a cyclic group optionally having substituent(s); R 3 and R 4 are each H or alkyl, or R 3 and R 4 form, together with the adjacent N, an nitrogen-containing heterocycle; and Y is a spacer.

    摘要翻译： 提供具有优异的酸分泌抑制作用的化合物，其表现出抗溃疡活性等。 由式（I）表示的化合物或其盐：其中环A是饱和或不饱和的5元杂环，其含有除碳原子外的环构成原子，至少一个选自氮原子，氧原子的杂原子 原子和硫原子，构成环的原子X 1和X 2相同或不同，分别为C或N，构成环的原子X 3和X 4相同或不同，分别为C，N， O或S（条件是其中X 1为N的吡咯环不包括在环A中），并且当构成环的原子X 3或X 4为C或N时，每个构成环的原子任选具有选定的取代基 任选取代的烷基，酰基，任选取代的羟基，任选取代的巯基，任选取代的氨基，卤素，氰基和硝基; R 1和R 2各自为任选具有取代基的环状基团; R 3和R 4各自为H或烷基，或R 3和R 4与相邻的N一起形成含氮杂环; Y是间隔物。

    PYRROLE COMPOUNDS
    4.
    发明公开
    PYRROLE COMPOUNDS 有权
    吡咯

    公开(公告)号：EP2114917A2

    公开(公告)日：2009-11-11

    申请号：EP08721310.4

    申请日：2008-02-27

    申请人： Takeda Pharmaceutical Company Limited

    发明人： KAJINO, Masahiro ,  NISHIDA, Haruyuki ,  ARIKAWA, Yasuyoshi ,  HIRASE, Keizo ,  ONO, Koji

    IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/4439 ,  A61P1/04

    CPC分类号： C07D401/04

    摘要： The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity, which is represented by the formula (I) wherein R1 is an optionally substituted cyclic group, R2 is a substituent, R3 is an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, R4 and R5 are each a hydrogen atom, an optionally substituted alkyl group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, a halogen atom, a cyano group or a nitro group, R6 and R6' are each a hydrogen atom or an alkyl group, and n is an integer of 0 - 3, or a salt thereof.