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1.发明公开
公开(公告)号：EP2789338A2
公开(公告)日：2014-10-15
申请号：EP14167191.7
申请日：2008-11-14
发明人： Matsumoto, Takahiro , Nagamiya, Hiroyuki , Maezaki, Hironobu , Kusumoto, Tomokazu , Yoshikawa, Kyoko , Furukawa, Hideki , Kamo, Izumi
IPC分类号： A61K31/5377 , A61K31/55 , G01N33/50 , C07D471/04 , G01N33/68 , A61K31/4545
CPC分类号： A61K31/5377 , A61K31/4545 , A61K31/55 , C07D471/04 , G01N33/5088 , G01N33/6893 , G01N2800/34
摘要： Described is a method of screening for a drug for the prophylaxis or treatment of cystoceles or enteroceles, comprising increasing an intravesical pressure after bilateral transection of the hypogastric nerve and pudendal nerve of an animal, and measuring a closure response in the urethra, the rectum or the vagina observed at that time.
摘要翻译： 描述了筛选用于预防或治疗膀胱或肠的药物的方法，包括在双侧横断动物的下腹神经和阴部神经之后增加膀胱内压力，并测量尿道，直肠或 当时观察到阴道。
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2.发明公开Method of screening preventives/remedies for stress urinary incontinence 审中-公开甄子ren v on enz enz enz enz enz enz enz enz enz enz enz enz enz
公开(公告)号：EP2400300A1
公开(公告)日：2011-12-28
申请号：EP11181877.9
申请日：2005-08-24
发明人： Kamo, Izumi , Hashimoto, Tadatoshi
IPC分类号： G01N33/50
CPC分类号： A61K31/5517 , A61K31/00 , A61K31/136 , A61K31/137 , A61K31/165 , A61K31/381 , A61K31/397 , A61K31/4025 , A61K31/4045 , A61K31/416 , A61K31/435 , A61K31/437 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5375 , A61K31/5383 , A61K31/542 , A61K31/55 , A61K31/551 , A61K31/568 , G01N33/5088
摘要： The invention relates to a method of screening for a substance that increases the leak point pressure during increase in abdominal pressure and a method of screening for a drug for the prophylaxis or treatment of abdominal pressure incontinence.
摘要翻译： 本发明涉及一种筛选在增加腹压期间增加泄漏点压力的物质的方法以及筛选用于预防或治疗腹压尿失禁的药物的方法。
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公开(公告)号：EP2789338A3
公开(公告)日：2015-01-14
申请号：EP14167191.7
申请日：2008-11-14
发明人： Matsumoto, Takahiro , Nagamiya, Hiroyuki , Maezaki, Hironobu , Kusumoto, Tomokazu , Yoshikawa, Kyoko , Furukawa, Hideki , Kamo, Izumi
IPC分类号： A61K31/5377 , A61K31/55 , G01N33/50 , C07D471/04 , G01N33/68 , A61K31/4545
CPC分类号： A61K31/5377 , A61K31/4545 , A61K31/55 , C07D471/04 , G01N33/5088 , G01N33/6893 , G01N2800/34
摘要： Described is a method of screening for a drug for the prophylaxis or treatment of cystoceles or enteroceles, comprising increasing an intravesical pressure after bilateral transection of the hypogastric nerve and pudendal nerve of an animal, and measuring a closure response in the urethra, the rectum or the vagina observed at that time.
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4.发明公开Fused heterocyclic compound and use thereof 审中-公开Kondensierte hybridlische Verbindung und ihre Verwendung
公开(公告)号：EP2742936A1
公开(公告)日：2014-06-18
申请号：EP13195343.2
申请日：2007-05-15
IPC分类号： A61K31/00 , A61K31/4353 , A61K31/553 , A61P3/04 , A61P13/02 , A61P15/02 , A61P21/00 , A61P43/00 , C07D223/16 , C07D487/04 , C07D498/04 , C07D519/00 , G01N33/94
CPC分类号： A61K31/553 , A61B5/04882 , A61B5/202 , A61B5/205 , A61K31/00 , A61K31/4353 , A61N1/36007 , C07D223/16 , C07D487/04 , C07D498/04 , C07D519/00 , G01N33/942
摘要： The present invention relates to a serotonin 5-HT 2C receptor activator for use in the prophylaxis or treatment of pelvic organ prolapse (genital organ prolapse), rectal prolapse or post-micturition dribble.
摘要翻译： 本发明涉及用于预防或治疗盆腔器官脱垂（生殖器官脱垂），直肠脱垂或排尿后运球的5-羟色胺5-HT 2C受体激活剂。
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公开(公告)号：EP2727585A1
公开(公告)日：2014-05-07
申请号：EP13195352.3
申请日：2007-05-15
IPC分类号： A61K31/00 , A61K31/4353 , A61K31/553 , A61P3/04 , A61P13/02 , A61P15/02 , A61P21/00 , A61P43/00 , C07D223/16 , C07D487/04 , C07D498/04 , C07D519/00 , G01N33/94 , A61K49/00
CPC分类号： A61K31/553 , A61B5/04882 , A61B5/202 , A61B5/205 , A61K31/00 , A61K31/4353 , A61N1/36007 , C07D223/16 , C07D487/04 , C07D498/04 , C07D519/00 , G01N33/942
摘要： The present invention relates to a method of screening for a substance that increases pelvic floor muscles contraction, comprising increasing an intravesical pressure after bilateral transection of the hypogastric nerve and pudendal nerve of an animal, and (i) measuring a closure response in the urinary tract, rectum or vagina observed at that time, or (ii) measuring the leak point pressure at that time.
摘要翻译： 本发明涉及一种筛选增加盆底肌肉收缩的物质的方法，包括增加动物的下腹神经和阴部神经的双侧横断后的膀胱内压力，以及（i）测量尿路中的闭合反应 ，当时观察到的直肠或阴道，或（ii）测量此时的泄漏点压力。
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6.发明公开Preventives/remedies for stress urinary incontinence and method of screening the same 审中-公开手段尿失禁和提供相关应力分析法种的预防/治疗
公开(公告)号：EP2248524A3
公开(公告)日：2011-03-09
申请号：EP10174167.6
申请日：2005-08-24
发明人： Kamo, Izumi , Hashimoto, Tadatoshi
CPC分类号： A61K31/5517 , A61K31/00 , A61K31/136 , A61K31/137 , A61K31/165 , A61K31/381 , A61K31/397 , A61K31/4025 , A61K31/4045 , A61K31/416 , A61K31/435 , A61K31/437 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5375 , A61K31/5383 , A61K31/542 , A61K31/55 , A61K31/551 , A61K31/568 , G01N33/5088
摘要： APD-356 for use as an agent for the prophylaxis or treatment of stress urinary incontinence.
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7.发明公开Preventives/remedies for stress urinary incontinence and method of screening the same 审中-公开剂预防/治疗压力性尿失禁和筛选方法及其的
公开(公告)号：EP2248524A2
公开(公告)日：2010-11-10
申请号：EP10174167.6
申请日：2005-08-24
发明人： Kamo, Izumi , Hashimoto, Tadatoshi
CPC分类号： A61K31/5517 , A61K31/00 , A61K31/136 , A61K31/137 , A61K31/165 , A61K31/381 , A61K31/397 , A61K31/4025 , A61K31/4045 , A61K31/416 , A61K31/435 , A61K31/437 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5375 , A61K31/5383 , A61K31/542 , A61K31/55 , A61K31/551 , A61K31/568 , G01N33/5088
摘要： APD-356 for use as an agent for the prophylaxis or treatment of stress urinary incontinence.
摘要翻译： APD-356用作用于预防或治疗压力性尿失禁的试剂。
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