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公开(公告)号：EP3536324A1
公开(公告)日：2019-09-11
申请号：EP19152036.0
申请日：2015-11-19
IPC分类号： A61K31/53
摘要： The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1:
which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.-
公开(公告)号：EP3083620B1
公开(公告)日：2018-10-03
申请号：EP14833425.3
申请日：2014-12-19
发明人： BROWN, Jason , HITCHCOCK, Stephen , HOPKINS, Maria , KIKUCHI, Shota , MONENSCHEIN, Holger , REICHARD, Holly , SCHLEICHER, Kristin , SUN, Hukai , MACKLIN, Todd
IPC分类号： C07D471/04 , A61K31/4985 , A61P25/16
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.
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公开(公告)号：EP2875012A1
公开(公告)日：2015-05-27
申请号：EP13742568.2
申请日：2013-07-16
发明人： HITCHCOCK, Stephen , MONENSCHEIN, Holdger , REICHARD, Holly , SUN, Huikai , KIKUCHI, Shota , MACKLIN, Todd , HOPKINS, Maria
IPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D451/12 , C07D471/02 , C07D487/14 , C07D498/08
CPC分类号： C07D498/08 , A61K31/19 , A61K31/5386 , C07C53/18 , C07C53/40 , C07D221/22 , C07D451/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D519/00
摘要： The present invention provides 5-HT3 receptor antagonists of Formula (I): which are useful for the treatment of diseases treatable by inhibition of 5-HT3 receptor such as emesis, pain, drug addiction, neurodegenerative and psychiatric disorders, and GI disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
摘要翻译： 本发明提供了式（I）的5-HT 3受体拮抗剂：其可用于治疗通过抑制5-HT 3受体如呕吐，疼痛，药物成瘾，神经变性和精神疾病以及GI障碍而可治疗的疾病。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：EP4031552A1
公开(公告)日：2022-07-27
申请号：EP20781670.3
申请日：2020-09-15
发明人： MONENSCHEIN, Holger , MURPHY, Sean , OLSEN, Scott , O'ROURKE, Natasha , REICHARD, Holly , DAVIS, Melinda , LAM, Betty
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
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公开(公告)号：EP2875012B1
公开(公告)日：2019-09-04
申请号：EP13742568.2
申请日：2013-07-16
发明人： HITCHCOCK, Stephen , MONENSCHEIN, Holdger , REICHARD, Holly , SUN, Huikai , KIKUCHI, Shota , MACKLIN, Todd , HOPKINS, Maria
IPC分类号： C07D471/08 , C07D471/04 , C07D453/02 , C07D221/22 , C07D451/12 , C07D498/08 , A61K31/19 , A61K31/5386 , C07D519/00 , C07C53/40 , C07C53/18
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公开(公告)号：EP3312169A1
公开(公告)日：2018-04-25
申请号：EP17198245.7
申请日：2013-07-16
发明人： HITCHCOCK, Stephen , MONENSCHEIN, Holger , REICHARD, Holly , SUN, Huikai , KIKUCHI, Shota , MACKLIN, Todd , HOPKINS, Maria
IPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D451/12 , C07D471/02 , C07D487/14 , C07D498/08 , A61K31/19 , A61K31/5386 , C07D221/22 , C07D453/02 , C07D471/04 , C07D471/08 , C07D519/00 , C07C53/18 , C07C53/40
CPC分类号： C07D498/08 , A61K31/19 , A61K31/5386 , C07C53/18 , C07C53/40 , C07D221/22 , C07D451/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D519/00
摘要： The present invention provides 5-HT3 receptor antagonists of Formula (I):
which are useful for the treatment of diseases treatable by inhibition of 5-HT3 receptor such as emesis, pain, drug addiction, neurodegenerative and psychiatric disorders, and GI disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.摘要翻译： 本发明提供式（I）的5-HT 3受体拮抗剂：其可用于治疗可通过抑制5-HT 3受体治疗的疾病，例如呕吐，疼痛，药物成瘾，神经变性和精神疾病以及GI障碍。 还提供了含有这些化合物的药物组合物以及制备这些化合物的方法。
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公开(公告)号：EP2875011B1
公开(公告)日：2018-01-10
申请号：EP13742355.4
申请日：2013-07-16
发明人： HITCHCOCK, Stephen , MONENSCHEIN, Holger , REICHARD, Holly , SUN, Huikai , KIKUCHI, Shota , MACKLIN, Todd , HOPKINS, Maria
IPC分类号： C07D221/22 , C07D471/04 , C07D453/02 , C07D471/08 , C07C53/18 , A61K31/19 , A61K31/5386 , C07D451/12 , C07D498/08 , C07D519/00 , C07C53/40
CPC分类号： C07D498/08 , A61K31/19 , A61K31/5386 , C07C53/18 , C07C53/40 , C07D221/22 , C07D451/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D519/00
摘要： which are useful for the treatment of diseases treatable by inhibition of 5-HT3 receptor such as emesis, pain, drug addiction, neurodegenerative and psychiatric disorders, and GI disorders. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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公开(公告)号：EP3221298B1
公开(公告)日：2019-04-03
申请号：EP15816275.0
申请日：2015-11-19
IPC分类号： C07D253/08 , A61K31/53
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公开(公告)号：EP3453709A1
公开(公告)日：2019-03-13
申请号：EP18187138.5
申请日：2014-12-19
发明人： BROWN, Jason , HITCHCOCK, Stephen , HOPKINS, Maria , KIKUCHI, Shota , MONENSCHEIN, Holger , REICHARD, Holly , SCHLEICHER, Kristin , SUN, Hukai , MACKLIN, Todd
IPC分类号： C07D471/04 , A61K31/4985 , A61P25/16
摘要： The present invention provides compounds of formula I:
which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.-
10.发明公开4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINES AS MODULATORS OF GPR139 审中-公开4-OXO-3,4-二氢-1,2,3-苯并三氮唑作为GPR139调节剂
公开(公告)号：EP3221298A1
公开(公告)日：2017-09-27
申请号：EP15816275.0
申请日：2015-11-19
IPC分类号： C07D253/08 , A61K31/53
CPC分类号： A61K31/53 , C07D253/08
摘要： The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: which are agonists of GPR139, certain compounds encompassed by formula 1, pharmaceutical compositions thereof, processes for making the compounds, and intermediates thereof.
摘要翻译： 它们是GPR139的激动剂，式1涵盖的某些化合物，其药物组合物，制备该化合物的方法及其中间体。
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