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1.发明授权ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS 有权芳基取代的烯胺和它们的用途AS和胆碱能受体激动剂
公开(公告)号：EP1086082B9
公开(公告)日：2005-03-02
申请号：EP99926152.2
申请日：1999-06-03
申请人： Targacept, Inc.
发明人： CALDWELL, William, Scott , DULL, Gary, Maurice , BHATTI, Balwinder, Singh , HADIMANI, Srishailkumar, B. , PARK, Haeil , WAGNER, Jared, Miller , CROOKS, Peter, Anthony , LIPPIELLO, Patrick, Michael , BENCHERIF, Merouane
IPC分类号： C07D213/38 , C07D213/62 , C07D213/61 , C07D213/64 , C07D239/26 , A61K31/44
CPC分类号： C07D213/73 , A61K31/44 , A61K31/4406 , A61K31/505 , C07D213/38 , C07D213/61 , C07D213/65 , C07D239/26
摘要： Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5- (3-pyridyl) -4-penten-2-amine, (4E) -N-methyl-5- (5-pyrimidinyl) -4-penten-2-amine, (4E)-N-methyl-5-( 5-methoxy-3-pyridyl) -4-penten-2-amine, (4E)-N- methyl-5- (6-amino-5-methyl -3-pyridyl)-4-penten -2-amine, (2R)-(4E) -N-methyl-5-(3-pyridyl) -4-penten-2-amine, (2R)-(4E)-N- methyl-5-(5- isopropoxy-3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-bromo-3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-ethoxy-3- pyridyl)-4-penten- 2-amine, (2S)-(4E)-N- methyl-5-(3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-isopropoxy-3- pyridyl)-4- penten-2-amine and (2S)-(4E)-N-methyl -5-(5-isopropoxy -3-pyridyl) -4-penten-2-amine.
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2.发明授权ARYLSUBSTITUTED OLEFINIC AMINES AND THEIR USE AS CHOLINERGIC RECEPTORS AGONISTS 有权芳基取代的烯胺和它们的用途AS和胆碱能受体激动剂
公开(公告)号：EP1086082B1
公开(公告)日：2004-08-18
申请号：EP99926152.2
申请日：1999-06-03
申请人： Targacept, Inc.
发明人： CALDWELL, William, Scott , DULL, Gary, Maurice , BHATTI, Balwinder, Singh , HADIMANI, Srishailkumar, B. , PARK, Haeil , WAGNER, Jared, Miller , CROOKS, Peter, Anthony , LIPPIELLO, Patrick, Michael , BENCHERIF, Merouane
IPC分类号： C07D213/38 , C07D213/62 , C07D213/61 , C07D213/64 , C07D239/26 , A61K31/44
CPC分类号： C07D213/73 , A61K31/44 , A61K31/4406 , A61K31/505 , C07D213/38 , C07D213/61 , C07D213/65 , C07D239/26
摘要： Compounds incorporating aryl substituted olefinic amine are provided. Representative compounds are (4E)-N-methyl-5- (3-pyridyl) -4-penten-2-amine, (4E) -N-methyl-5- (5-pyrimidinyl) -4-penten-2-amine, (4E)-N-methyl-5-( 5-methoxy-3-pyridyl) -4-penten-2-amine, (4E)-N- methyl-5- (6-amino-5-methyl -3-pyridyl)-4-penten -2-amine, (2R)-(4E) -N-methyl-5-(3-pyridyl) -4-penten-2-amine, (2R)-(4E)-N- methyl-5-(5- isopropoxy-3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-bromo-3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-ethoxy-3- pyridyl)-4-penten- 2-amine, (2S)-(4E)-N- methyl-5-(3-pyridyl) -4-penten-2-amine, (4E)-N-methyl -5-(5-isopropoxy-3- pyridyl)-4- penten-2-amine and (2S)-(4E)-N-methyl -5-(5-isopropoxy -3-pyridyl) -4-penten-2-amine.
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