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公开(公告)号：EP2344496A1
公开(公告)日：2011-07-20
申请号：EP09792165.4
申请日：2009-09-02
申请人： Targacept Inc.
发明人： STRACHAN, Jon-Paul , BHATTI, Balwinder Singh , MAZUROV, Anatoly , KLUCIK, Jozef , XIAO, Yun-De , HAMMOND, Philip S. , KOMBO, David , MIAO, Lan , SPEAKE, Jason Daniel , YOHANNES, Daniel
IPC分类号： C07D471/08 , A61K31/407 , A61P25/00
CPC分类号： C07D471/08
摘要： The present invention relates to compounds of the following formulae I and II that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS). Formula (I ), Formula (Il)
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2.发明授权PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S,3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUOROBENZAMIDE 有权制备和治疗用途（2S，3R）-N-2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-3,5-二氟苯甲酰胺
公开(公告)号：EP2389378B1
公开(公告)日：2014-06-25
申请号：EP10701307.0
申请日：2010-01-25
申请人： Targacept, Inc.
发明人： BENCHERIF, Merouane , FEDOROV, Nikolai , HAUSER, Terry , JORDAN, Kristen , LETCHWORTH, Sharon, Rae , MAZUROV, Anatoly , MUNOZ, Julio, A. , SPEAKE, Jason , YOHANNES, Daniel
IPC分类号： C07D453/02 , A61K31/439 , A61P3/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/28 , A61P29/00
CPC分类号： A61K31/444 , C07D453/02
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公开(公告)号：EP2576496A1
公开(公告)日：2013-04-10
申请号：EP11724498.8
申请日：2011-05-24
申请人： Targacept, Inc.
发明人： AKIREDDY, Srinivasa Rao , BHATTI, Balwinder Singh , HEEMSTRA, Ronald Joseph , MELVIN, Matt S. , SPEAKE, Jason , XIAO, Yunde , YOHANNES, Daniel
IPC分类号： C07C211/41 , A61K31/13 , A61P9/12 , A61P25/24
CPC分类号： A61K31/13 , A61K31/397 , A61K31/40 , C07C211/38 , C07C211/41 , C07D205/04 , C07D295/033
摘要： The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
摘要翻译： 本发明涉及作为非竞争性拮抗剂调节烟碱受体的化合物，其合成方法，使用方法及其药物组合物。
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4.发明公开DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 审中-公开OXABISPIDIN作为配体为神经元烟碱型乙酰胆碱受体衍生物
公开(公告)号：EP2356125A1
公开(公告)日：2011-08-17
申请号：EP09774421.3
申请日：2009-07-01
申请人： Targacept, Inc.
发明人： MAZUROV, Anatoly , MIAO, Lan , XIAO, Yun-de , YOHANNES, Daniel , AKIREDDY, Srinivisa, Rao , BREINING, Scott, R. , KOMBO, David , MURTHY, V. Srinivasa , FEDOROV, Nikolai , SHOWALTER, Todd
IPC分类号： C07D498/04 , A61K31/5386 , A61P25/00
CPC分类号： C07D498/04
摘要： The present invention relates to compounds of formula (I) that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with d sfunction of the central nervous s stem (CNS).
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公开(公告)号：EP2773609A2
公开(公告)日：2014-09-10
申请号：EP12846619.0
申请日：2012-11-01
申请人： Targacept, Inc.
发明人： AKIREDDY, Srinivasa Rao , SPEAKE, Jason , XIAO, Yunde , GENUS, John , BHATTI, Bahwinder Singh , YOHANNES, Daniel
IPC分类号： C07C211/16 , A61K31/13 , A61P25/24 , A61P9/12
CPC分类号： C07C211/38 , C07C215/42 , C07C215/44
摘要： The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions.
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6.发明公开NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS 审中-公开NICHTKOMPETITIVE ANTAGONISTEN DES NIKOTINREZEPTORS
公开(公告)号：EP2661421A2
公开(公告)日：2013-11-13
申请号：EP12731898.8
申请日：2012-01-05
申请人： Targacept, Inc.
发明人： AKIREDDY, Srinivasa Rao , BREINING, Scott R. , MELVIN, Matt S. , MURTHY, Srinivasa V. , MAZUROV, Anatoly A. , BHATTI, Balwinder Singh , STRACHAN, Jon-Paul , HEEMSTRA, Ronald Joseph , SHOWALTER, Todd , XIAO, Yunde , HAMMOND, Philip S. , MIAO, Lan , KOMBO, David , YOHANNES, Daniel , SPEAKE, Jason
IPC分类号： C07C211/35 , A61K31/13 , A61P9/12
CPC分类号： C07D493/08 , C07C211/38 , C07C2602/40 , C07C2602/42 , C07C2602/44
摘要： The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for their use, and their pharmaceutical compositions.
摘要翻译： 本发明涉及将烟碱受体调节为非竞争性拮抗剂的化合物，其合成方法，其使用方法及其药物组合物。
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7.发明公开PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S,3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUOROBENZAMIDE 有权制备和治疗用途（2S，3R）-N-2 - （（3-吡啶基）甲基）-1-氮杂双环[2.2.2]辛-3-基）-3,5-二氟苯甲酰胺
公开(公告)号：EP2389378A1
公开(公告)日：2011-11-30
申请号：EP10701307.0
申请日：2010-01-25
申请人： Targacept, Inc.
发明人： BENCHERIF, Merouane , FEDOROV, Nikolai , HAUSER, Terry , JORDAN, Kristen , LETCHWORTH, Sharon, Rae , MAZUROV, Anatoly , MUNOZ, Julio, A. , SPEAKE, Jason , YOHANNES, Daniel
IPC分类号： C07D453/02 , A61K31/439 , A61P3/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/28 , A61P29/00
CPC分类号： A61K31/444 , C07D453/02
摘要： The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
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8.发明公开(R) -3- (E) -2- (PYRR0LIDIN-3-YL) VINYL) -5- (TETRAHYDR0PYRAN-4-YL0XY) PYRIDINE, ITS SALTS, ITS SYNTHESIS AND ITS USE AS LIGAND FOR NICOTINIC ACETYLCHOLINERGIC RECEPTORS 审中-公开（R）-2-（E）-2-（吡咯烷-3-基）乙烯基）-5-（四氢吡喃-4-基氧基）吡啶，其盐，其合成，以及其作为烟碱乙酰胆碱受体的配体的使用
公开(公告)号：EP2358705A1
公开(公告)日：2011-08-24
申请号：EP09775410.5
申请日：2009-11-30
申请人： Targacept Inc.
发明人： AKIREDDY, Srinivisa, Rao , BREINING, Scott, R. , CUTHBERTSON, Timothy, J. , DULL, Gary, Maurice , GATTO, Gregory, J. , GENUS, John , HAMMOND, Philip, S. , MITCHENER, Joseph, Pike, Jr. , MUNOZ, Julio, A. , OTTEN, Pieter, Albert , YOHANNES, Daniel , FEDOROV, Nikolai
IPC分类号： C07D405/14 , A61P25/00 , A61K31/4439
CPC分类号： A61K31/4439 , C07D405/14
摘要： The present invention relates to (R) -3- ( (E) -2- (pyrrolidin-3-yl) vinyl) -5- (tetrahydropyran-4-yloxy) pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions. The present invention relates also the use of this compound in the manufacture of a medicament for the treatment of CNS related disorders.
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