公开(公告)号：EP4294210A1

公开(公告)日：2023-12-27

申请号：EP22706966.3

申请日：2022-02-14

申请人： Tate & Lyle Solutions USA LLC ,  University College Cork - National University of Ireland, Cork ,  Agriculture and Food Development Authority (TEAGASC)

发明人： CAPLICE, Noel ,  STANTON, Catherine ,  ROSS, Paul ,  HERISSON, Florence ,  KARNIK, Kavita ,  DE SOUZA, Mervyn ,  LAURIE, Ieva ,  CANENE-ADAMS, Kirstie

IPC分类号： A23L29/269 ,  A23L33/135 ,  A23L33/21 ,  A61K35/747

公开(公告)号：EP3713587A2

公开(公告)日：2020-09-30

申请号：EP18830137.8

申请日：2018-11-26

申请人： University College Cork-National University of Ireland, Cork ,  Agriculture and Food Development Authority (TEAGASC)

发明人： STANTON, Catherine ,  ROSS, Paul ,  FITZGERALD, Ger ,  RYAN, Tony

IPC分类号： A61K35/745 ,  A23L33/135 ,  A61P1/00 ,  A23L33/00

公开(公告)号：EP3338785A1

公开(公告)日：2018-06-27

申请号：EP16205996.8

申请日：2016-12-21

申请人： Agriculture and Food Development Authority (TEAGASC) ,  University College Cork - National University of Ireland, Cork

发明人： HILL, Colin ,  ROSS, Paul ,  REA, Mary Clare ,  ALEMAYEHU, Debebe ,  MURPHY, Eileen Frances

IPC分类号： A61K35/747 ,  G01N33/48 ,  C12N1/20 ,  A61P31/04

CPC分类号： A61K35/747 ,  C12N1/20 ,  C12Q1/045 ,  G01N2333/33 ,  G01N2333/335

摘要： Clostridium difficile is one of the most common causes of health-care acquired diarrhoea, resulting in a spectrum of disease from mild diarrhoea to life-threatening illness. Particular human Lactobacillus strains, including Lactobacillus gasseri APC678, are described as useful therapeutic agents to target C. difficile colonisation or infection.

公开(公告)号：EP2828375B1

公开(公告)日：2017-11-22

申请号：EP13708357.2

申请日：2013-01-21

申请人： University College Cork-National University of Ireland, Cork ,  Agriculture and Food Development Authority (TEAGASC)

发明人： STANTON, Catherine ,  ROSS, Paul ,  CRYAN, John ,  DINAN, Ted

IPC分类号： C12N1/20 ,  C12P13/00 ,  A61K35/74 ,  C12R1/01 ,  C12R1/24

CPC分类号： C12R1/01 ,  A61K35/747 ,  C12N1/20 ,  C12P13/005 ,  C12R1/24

摘要： Isolated bacteria are described that are characterised by being culturable, derived from a human neonatal gastrointestinal tract, and having the ability to produce gamma-aminobutyric acid. Also described is the use of the GABA-producing bacteria in the treatment or regulation of cardiovascular function, mood disturbance, anxiety, stress, pain and proliferative disorders.

公开(公告)号：EP2828375A1

公开(公告)日：2015-01-28

申请号：EP13708357.2

申请日：2013-01-21

申请人： University College Cork-National University of Ireland, Cork ,  Agriculture and Food Development Authority (TEAGASC)

发明人： STANTON, Catherine ,  ROSS, Paul ,  CRYAN, John ,  DINAN, Ted

IPC分类号： C12N1/20 ,  C12P13/00 ,  A61K35/74 ,  C12R1/24 ,  C12R1/01

CPC分类号： C12R1/01 ,  A61K35/747 ,  C12N1/20 ,  C12P13/005 ,  C12R1/24

摘要： Isolated bacteria are described that are characterised by being culturable, derived from a human neonatal gastrointestinal tract, and having the ability to produce gamma-aminobutyric acid. Also described is the use of the GABA-producing bacteria in the treatment or regulation of cardiovascular function, mood disturbance, anxiety, stress, pain and proliferative disorders.

摘要翻译： 描述了特征在于可培养的分离的细菌，其衍生自人类新生儿胃肠道，并且具有产生γ-氨基丁酸的能力。 还描述了GABA产生细菌在治疗或调节心血管功能，情绪障碍，焦虑，压力，疼痛和增殖性疾病中的用途。

公开(公告)号：EP1874917B1

公开(公告)日：2012-03-14

申请号：EP06728131.1

申请日：2006-04-06

申请人： TEAGASC, The Agriculture and Food Development Authority ,  University College Cork-National University of Ireland, Cork

发明人： STANTON, Catherine ,  HILL, Colin, Department of Microbiology ,  FITZGERALD, Ger, Department of Microbiology ,  ROSS, Paul

IPC分类号： C12N1/20 ,  A23L1/30 ,  A23K1/00

CPC分类号： A23K10/18

摘要： The invention provides a probiotic composition to alleviate Salmonella infection in farm animals. The composition may comprise at least one of Lactobacillus murinus, Lactobacillus pentosus, Lactobacillus salivarius sub-species salivarius, and Pediococcus pentosaceus. The composition maybe formulated as an animal feedstuff, or as a pharmaceutical composition.

公开(公告)号：EP2227484A1

公开(公告)日：2010-09-15

申请号：EP08855713.7

申请日：2008-11-28

申请人： TEAGASC, The Agriculture and Food Development Authority ,  University College Cork-National University of Ireland, Cork

发明人： HILL, Colin ,  REA, Mary ,  ROSS, Paul

IPC分类号： C07K14/32 ,  C12N1/20

CPC分类号： C07K14/32 ,  A61K38/00 ,  A61K2035/11 ,  C12N1/06 ,  C12R1/075 ,  Y10S435/832

摘要： The present invention relates to a new bacteriocin, to microbial strains which can produce it and to uses of the bacteriocin and the strains. The bacteriocin is effective against Clostridium difficile and Listeria monocytogenes amongst other organisms.

摘要翻译： 本发明涉及一种新的细菌素，可以产生它的微生物菌株以及细菌素和菌株的用途。 细菌素在其他生物体内对艰难梭菌和单核细胞增生利斯特氏菌有效。

公开(公告)号：EP2192909A2

公开(公告)日：2010-06-09

申请号：EP08804932.5

申请日：2008-09-30

申请人： University College Cork-National University of Ireland, Cork ,  TEAGASC, The Agriculture and Food Development Authority ,  Alimentary Health Ltd.

发明人： O'MAHONY, Liam ,  SHANAHAN, Fergus ,  QUIGLEY, Eamonn ,  ROSS, Paul ,  STANTON, Catherine

IPC分类号： A61K35/74 ,  C12P7/64 ,  A23L1/30 ,  A61P25/28 ,  A61P1/00 ,  A61P17/00

CPC分类号： C12N1/20 ,  A23L33/135 ,  A61K31/201 ,  A61K35/74 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  C12P7/6427 ,  C12P7/6472 ,  C12R1/01

摘要： The current invention provides use of a CLA-producing bacterium for the in vivo conversion in the gut of polyunsaturated fatty acids to CLA. The CLA-producing bacterium is selected from one or more of the group consisting of propionibacteria, lactobacilli, lactococci and streptococci, and bifidobacteria.

公开(公告)号：EP3822285A1

公开(公告)日：2021-05-19

申请号：EP19208735.1

申请日：2019-11-12

申请人： University College Cork-National University of Ireland, Cork ,  TEAGASC, The Agriculture and Food Development Authority

发明人： COTTER, Paul ,  SHEEHAN, Diarmuid ,  BHAGYA JONNALA, Rekha ,  FIELD, Des ,  HILL, Colin ,  ROSS, Paul

IPC分类号： C07K14/315 ,  A23L3/3526 ,  A61K38/16

摘要： The invention relates to a variant nisin peptide, wherein the variant nisin peptide is a modified variant of wild-type nisin, wherein the modification comprises or consists of an amino acid residue modification selected from: i) M17Q or M17A; ii) T2L; and iii) one set of modified hinge residues selected from a) N20H and M21T, b) N20V, M21G, and K22A, c) N20V, M21G, and K22V or d) N20V, M21G, and K22T; or v) combinations of modifications i), ii), and iii), and related medical uses and products comprising such nisin peptides.

公开(公告)号：EP2736924A1

公开(公告)日：2014-06-04

申请号：EP12748662.9

申请日：2012-07-27

申请人： University College Cork, National University Of Ireland ,  Agriculture and Food Development Authority (TEAGASC)

发明人： ROSS, Paul ,  O'SHEA, Eileen ,  HILL, Colin

IPC分类号： C07K14/335

CPC分类号： C07K14/335 ,  A23L33/18 ,  A23Y2220/79 ,  A61K35/00 ,  A61K38/00 ,  C12R1/225

摘要： An antimicrobial peptide having potent antibacterial activity against Listeria monocytogenes and Staphylococcus aureus is described. Also described is an isolated Lactobacillus salivarius DPC6502 strain as deposited with the National Collection of Industrial and Marine Bacteria under the Accession No. NCIMB 41840, and variants thereof, wherein the isolated bacteria and variants thereof express an antimicrobial peptide having potent antibacterial activity against Lactobacillus delbrueckii subspecies bulgaricus, Listeria and Staphylococcus aureus.

摘要翻译： 描述了对单核细胞增生利斯特氏菌和金黄色葡萄球菌具有有效抗菌活性的抗微生物肽。 还描述了以保藏号NCIMB 41840保藏在National Collection of Industrial and Marine Bacteria的分离的唾液乳杆菌DPC6502菌株及其变体，其中分离的细菌及其变体表达对德氏乳杆菌具有强抗菌活性的抗微生物肽 亚种保加利亚，李斯特菌和金黄色葡萄球菌。