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    SENSOR DEVICE
    4.
    发明公开
    SENSOR DEVICE 审中-公开

    公开(公告)号：EP4417966A1

    公开(公告)日：2024-08-21

    申请号：EP23156911.2

    申请日：2023-02-15

    申请人： Technische Universität München

    发明人： SIMMEL, Friedrich ,  ROTHFISCHER, Florian ,  KOPPERGER, Enzo ,  LIST, Jonathan ,  LANGECKER, Martin

    IPC分类号： G01N21/552 ,  G01N21/64

    CPC分类号： G01N21/6458 ,  G01N21/6408 ,  G01N21/6428 ,  G01N2021/644120130101 ,  G01N21/553

    摘要： The invention concerns a sensor device (1) for detecting the presence of one or more molecules (20) and/or of a class of molecules (20); comprising at least one first (nano-) structure (2); at least one second structure (3); at least one joining portion (4) respectively connecting the at least one first (nano-)structure (2) and the at least one second structure (3) and configured to allow a relative mobility between the at least one first (nano-)structure (2) and the at least one second structure (3), wherein the at least one joining portion (4) is an element separate from and connected to the at least one first (nano-)structure (2) and the at least one second structure (3) or wherein the at least one joining portion (4) is formed integrally with the at least one first (nano-)structure (2) and/or with the at least one second structure (3); one binding structure (5), especially one binding structure (5) per joining portion (4), configured to bind with a molecule, the presence of which is to be detected, wherein the binding structure (5) is located on the at least one first (nano-)structure (2) or on the at least one second structure (3) or on the at least one joining portion (4) such that said allowed relative mobility between the at least one first (nano-)structure (2) and the at least one second structure (3) is changed, especially limited, in a bound state of the binding structure (5) as compared to an unbound state of the binding structure (5); and a detecting means (100) for detecting said relative mobility between the at least one first (nano-)structure (2) and the at least one second structure (3).

    CHAMBER SYSTEM FOR CELL-FREE PRODUCTION OF PROTEINS OF INTEREST
    5.
    发明公开
    CHAMBER SYSTEM FOR CELL-FREE PRODUCTION OF PROTEINS OF INTEREST 审中-公开

    公开(公告)号：EP4407020A1

    公开(公告)日：2024-07-31

    申请号：EP23153442.1

    申请日：2023-01-26

    申请人： Technische Universität München

    发明人： VOGELE, Kilian ,  SIMMEL, Friedrich ,  WINZIG, Franziska

    IPC分类号： C12M1/00

    CPC分类号： C12M21/18 ,  C12M29/04 ,  C12M23/34 ,  C12M23/46 ,  C12P21/00

    摘要： The invention relates to a chamber system for cell-free production of proteins of interest, comprising:
    at least one reaction chamber (10), being configured to hold a reaction solution (12) and being configured to produce proteins of interest using the reaction solution (12);
    at least one feeding chamber (20), being disposed adjacent to the at least one reaction chamber (10) and being configured to hold a feeding solution (22);
    at least one semi-permeable membrane (30), connecting the at least one feeding chamber (20) with the at least one reaction chamber (10), wherein the semi-permeable membrane (30) is configured to allow diffusing at least part of the feeding solution (22) from the at least one feeding chamber (20) into the at least one reaction chamber (10);
    wherein the at least one feeding chamber (20) comprises a feeding chamber access (21) that is configured to allow access to the feeding solution (22) in the at least one feeding chamber (20).