公开(公告)号：EP3110810B1

公开(公告)日：2018-05-02

申请号：EP15713244.0

申请日：2015-02-27

申请人： Teijin Pharma Limited

发明人： BECK, Hilary Plake ,  BOOKER, Shon Keith ,  BREGMAN, Howard ,  CEE, Victor J. ,  CHAKKA, Nagasree ,  CUSHING, Timothy D. ,  EPSTEIN, Oleg ,  FOX, Brian M. ,  GEUNS-MEYER, Stephanie ,  HAO, Xiaolin ,  HIBIYA, Kenta ,  HIRATA, Jun ,  HUA, Zihao ,  HUMAN, Jason ,  KAKUDA, Shinji ,  LOPEZ, Patricia ,  NAKAJIMA, Ryota ,  OKADA, Kazuhisa ,  OLSON, Steven H. ,  OONO, Hiroyuki ,  PENNINGTON, Lewis D. ,  SASAKI, Kosuke ,  SHIMADA, Keiko ,  SHIN, Youngsook ,  WHITE, Ryan D. ,  WURZ, Ryan P. ,  YI, Shuyan ,  ZHENG, Xiao Mei

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D231/14 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/14 ,  C07D493/08 ,  A61K31/4155 ,  A61P29/00

CPC分类号： C07D231/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/14 ,  C07D493/08

摘要： The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

公开(公告)号：EP3110810A1

公开(公告)日：2017-01-04

申请号：EP15713244.0

申请日：2015-02-27

申请人： Teijin Pharma Limited ,  Amgen Inc.

发明人： BECK, Hilary Plake ,  BOOKER, Shon Keith ,  BREGMAN, Howard ,  CEE, Victor J. ,  CHAKKA, Nagasree ,  CUSHING, Timothy D. ,  EPSTEIN, Oleg ,  FOX, Brian M. ,  GEUNS-MEYER, Stephanie ,  HAO, Xiaolin ,  HIBIYA, Kenta ,  HIRATA, Jun ,  HUA, Zihao ,  HUMAN, Jason ,  KAKUDA, Shinji ,  LOPEZ, Patricia ,  NAKAJIMA, Ryota ,  OKADA, Kazuhisa ,  OLSON, Steven H. ,  OONO, Hiroyuki ,  PENNINGTON, Lewis D. ,  SASAKI, Kosuke ,  SHIMADA, Keiko ,  SHIN, Youngsook ,  WHITE, Ryan D. ,  WURZ, Ryan P. ,  YI, Shuyan ,  ZHENG, Xiao Mei

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D231/14 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/14 ,  C07D493/08 ,  A61K31/4155 ,  A61P29/00

CPC分类号： C07D231/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/14 ,  C07D493/08

摘要： The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

摘要翻译： 本发明涉及具有抑制RORγ活性功能的新型化合物。 本发明还涉及包含该化合物的药物组合物，该化合物在治疗或预防自身免疫性疾病，炎性疾病，代谢性疾病或癌症疾病中的用途。