-
公开(公告)号：EP4137481A1
公开(公告)日：2023-02-22
申请号：EP21789367.6
申请日：2021-04-15
发明人： SUGIYAMA, Sakae , YOKOSAKA, Takuya , MINAMIZONO, Kunio , KAWANA, Asahi , KANEKO, Toshiyuki , MARUYAMA, Akinobu , SASAKI, Kosuke , HOSODA, Shinnosuke , KOSHIMIZU, Masaki , TAKEUCHI, Susumu , KATO, Kenta , CHAKKA, Nagasree , JOHNSON, Brett M. , WHITE, Ryan d. , ZHAO, Wei
IPC分类号： C07D213/74 , A61K31/427 , A61K31/4439 , A61K31/444 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/551 , A61P3/10 , A61P7/10 , A61P9/04 , A61P9/12 , A61P11/00 , A61P13/12 , A61P21/04 , A61P31/04 , A61P35/00 , A61P43/00 , C07D237/20 , C07D239/34 , C07D239/42
摘要： A compound indicated by formula (I) or a pharmacologically acceptable salt thereof is provided as a compound that can be a therapeutic or prophylactic drug for TRPC6-related diseases, such as nephrotic syndrome, membranous nephropathy, acute renal failure, septicemia, chronic renal failure, diabetic nephropathy, pulmonary hypertension, acute lung injury, heart failure, malignant tumor, and muscular dystrophy. (In the formula, Ar 1 , Ar 2 , X 1 -X 3 , R 1 , R 3 , R 7 , R 8 , L 1 , and L 2 are as defined in the specifications.)
-
公开(公告)号：EP3110810A1
公开(公告)日：2017-01-04
申请号：EP15713244.0
申请日：2015-02-27
申请人： Teijin Pharma Limited , Amgen Inc.
发明人： BECK, Hilary Plake , BOOKER, Shon Keith , BREGMAN, Howard , CEE, Victor J. , CHAKKA, Nagasree , CUSHING, Timothy D. , EPSTEIN, Oleg , FOX, Brian M. , GEUNS-MEYER, Stephanie , HAO, Xiaolin , HIBIYA, Kenta , HIRATA, Jun , HUA, Zihao , HUMAN, Jason , KAKUDA, Shinji , LOPEZ, Patricia , NAKAJIMA, Ryota , OKADA, Kazuhisa , OLSON, Steven H. , OONO, Hiroyuki , PENNINGTON, Lewis D. , SASAKI, Kosuke , SHIMADA, Keiko , SHIN, Youngsook , WHITE, Ryan D. , WURZ, Ryan P. , YI, Shuyan , ZHENG, Xiao Mei
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D231/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/14 , C07D493/08 , A61K31/4155 , A61P29/00
CPC分类号： C07D231/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/14 , C07D493/08
摘要： The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.
摘要翻译： 本发明涉及具有抑制RORγ活性功能的新型化合物。 本发明还涉及包含该化合物的药物组合物，该化合物在治疗或预防自身免疫性疾病，炎性疾病，代谢性疾病或癌症疾病中的用途。
-
公开(公告)号：EP3952866A1
公开(公告)日：2022-02-16
申请号：EP20787966.9
申请日：2020-04-10
发明人： CHAKKA, Nagasree , GAO, Hua , GUZMAN-PEREZ, Angel , JOHNSON, Brett Michael , KIEFFER, Madeleine , MALINOWSKI, Justin , SCHENKEL, Laurie
IPC分类号： A61K31/4184 , A61K31/454 , A61P11/00 , A61P13/12
-
公开(公告)号：EP3110810B1
公开(公告)日：2018-05-02
申请号：EP15713244.0
申请日：2015-02-27
发明人： BECK, Hilary Plake , BOOKER, Shon Keith , BREGMAN, Howard , CEE, Victor J. , CHAKKA, Nagasree , CUSHING, Timothy D. , EPSTEIN, Oleg , FOX, Brian M. , GEUNS-MEYER, Stephanie , HAO, Xiaolin , HIBIYA, Kenta , HIRATA, Jun , HUA, Zihao , HUMAN, Jason , KAKUDA, Shinji , LOPEZ, Patricia , NAKAJIMA, Ryota , OKADA, Kazuhisa , OLSON, Steven H. , OONO, Hiroyuki , PENNINGTON, Lewis D. , SASAKI, Kosuke , SHIMADA, Keiko , SHIN, Youngsook , WHITE, Ryan D. , WURZ, Ryan P. , YI, Shuyan , ZHENG, Xiao Mei
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D231/14 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/14 , C07D493/08 , A61K31/4155 , A61P29/00
CPC分类号： C07D231/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/14 , C07D493/08
摘要： The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.
-
-
-
搜索结果
4 条记录 (耗时 0.02 秒)
