公开(公告)号：EP3761985A1

公开(公告)日：2021-01-13

申请号：EP19763857.0

申请日：2019-03-07

申请人： Temple University - Of The Commonwealth System of Higher Education

发明人： MERALI, Salim ,  BARRERO, Carlos, A. ,  CHILDERS, Wayne, E. ,  MORTON, George, C.

IPC分类号： A61K31/4985 ,  C07D498/04 ,  G01N33/50

公开(公告)号：EP2710384A1

公开(公告)日：2014-03-26

申请号：EP12782510.7

申请日：2012-05-11

申请人： Temple University Of The Commonwealth System Of Higher Education

发明人： MERALI, Salim ,  MONCADA, Camilo ,  KELSEN, Steven, G. ,  BARRERO, Carlos, A. ,  PEREZ LEAL, Oscar, Mauricio

IPC分类号： G01N33/68

CPC分类号： G01N33/6875 ,  G01N33/577 ,  G01N2440/12 ,  G01N2800/122 ,  G01N2800/56 ,  H01J49/0027

摘要： Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.

公开(公告)号：EP2710384B1

公开(公告)日：2017-11-08

申请号：EP12782510.7

申请日：2012-05-11

申请人： Temple University - Of The Commonwealth System of Higher Education

发明人： MERALI, Salim ,  MONCADA, Camilo ,  KELSEN, Steven, G. ,  BARRERO, Carlos, A. ,  PEREZ LEAL, Oscar, Mauricio

IPC分类号： G01N33/68 ,  G01N33/577

CPC分类号： G01N33/6875 ,  G01N33/577 ,  G01N2440/12 ,  G01N2800/122 ,  G01N2800/56 ,  H01J49/0027

摘要： Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.

公开(公告)号：EP4138812A1

公开(公告)日：2023-03-01

申请号：EP21724981.2

申请日：2021-04-23

申请人： Temple University - Of The Commonwealth System of Higher Education

发明人： MERALI, Salim ,  CHILDERS, Wayne, E. ,  BARRERO, Carlos ,  MORTON, George, C. ,  RICO, Mario Cesar

IPC分类号： A61K31/198 ,  A61K45/06 ,  C07C229/08 ,  C07C229/26 ,  A61P1/16 ,  G01N33/50

公开(公告)号：EP3761984A1

公开(公告)日：2021-01-13

申请号：EP19763756.4

申请日：2019-03-07

申请人： Temple University - Of The Commonwealth System of Higher Education

发明人： MERALI, Salim ,  BARRERO, Carlos, A. ,  CHILDERS, Wayne, E. ,  MORTON, George, C.

IPC分类号： A61K31/4985 ,  C07D498/04 ,  G01N33/50

公开(公告)号：EP3509575A1

公开(公告)日：2019-07-17

申请号：EP17849523.0

申请日：2017-09-07

申请人： Temple University Of The Commonwealth System Of Higher Education

发明人： MERALI, Salim ,  BARRERO, Carlos A. ,  CHILDERS, Wayne E. ,  MORTON, George C.

IPC分类号： A61K31/13 ,  A61K31/19