公开(公告)号：EP2309849B1

公开(公告)日：2015-09-02

申请号：EP09798325.8

申请日：2009-07-17

申请人： Tenax Therapeutics, Inc. ,  Virginia Commonwealth University

发明人： BULLOCK, M. Ross ,  SPIESS, Bruce ,  THOMPSON, Deborah, P.

IPC分类号： A01N29/02 ,  A61K31/02 ,  A61P9/10

CPC分类号： A61K31/02 ,  A61K9/0019 ,  A61K9/0026 ,  A61K47/02 ,  A61K47/10 ,  A61K47/24

公开(公告)号：EP2309849A1

公开(公告)日：2011-04-20

申请号：EP09798325.8

申请日：2009-07-17

申请人： Oxygen Biotherapeutics, Inc. ,  Virginia Commonwealth University

发明人： BULLOCK, M. Ross ,  SPIESS, Bruce ,  THOMPSON, Deborah, P.

IPC分类号： A01N29/02 ,  A61K31/02

CPC分类号： A61K31/02 ,  A61K9/0019 ,  A61K9/0026 ,  A61K47/02 ,  A61K47/10 ,  A61K47/24

摘要： This invention provides for methods of treating a subject suffering from central nervous system injury, including traumatic brain injury, comprising administering to the subject an amount of a perf luorocarbon. This invention also provides for use of a perf luorocarbon in the manufacture of a medicament for treating a subject suffering from central nervous system injury including traumatic brain injury. This invention further provides for a pharmaceutical composition comprising a perf luorocarbon for use in treating a subject suffering from central nervous system injury, including traumatic brain injury.

公开(公告)号：EP2024287A1

公开(公告)日：2009-02-18

申请号：EP07783748.2

申请日：2007-05-14

申请人： Virginia Commonwealth University

发明人： WARD, Kevin ,  HUVARD, Gary ,  CARPENTER, Everette ,  SANDHU, Gurbhagat ,  BARBEE, Robert ,  SPIESS, Bruce

IPC分类号： C01D1/32 ,  C01D3/16 ,  C01D7/26

CPC分类号： C01B13/0211 ,  A01N59/00 ,  A61L2/0082 ,  A61L2/0088 ,  A61L2/186 ,  A61L2/23 ,  A61L2202/24 ,  C01B15/03 ,  C01B15/032 ,  C02F1/722 ,  A01N25/02 ,  A01N25/30 ,  A01N27/00 ,  A01N59/16 ,  A01N59/20 ,  A01N2300/00

摘要： Methods and compositions for the controlled and sustained release of peroxides or oxygen to aqueous environments (e.g. a patient's body or circulatory system, or for other applications) or non-aqueous environments, include a material coating or encapsulating hydrogen peroxide, inorganic peroxides or peroxide adducts. In the case of peroxide adducts, and particularly in one type of embodiment, the peroxide adducts should be able to permeate the material, but water, hydrogen peroxide and inorganic peroxides should be able to permeate the material. The methods and compositions that allow the release of oxygen, H2O2 or inorganic peroxides from peroxide adducts with movement of these moieties across a selectively permeable barrier into, preferably, an aqueous environment. In the case of hydrogen peroxide, it can be acted upon by catalase or other enzymes, or be simply degraded, or are otherwise acted upon by enzymes or catalysts embedded in the selectively permeable barrier to produce, for example, O2. Alternatively, hydrogen peroxide or inorganic peroxides can be delivered selectively to a site of action of cleaning, disinfecting or other applications.

公开(公告)号：EP2252333A2

公开(公告)日：2010-11-24

申请号：EP09709900.6

申请日：2009-02-13

申请人： Oxygen Biotherapeutics, Inc. ,  Virginia Commonwealth University

发明人： WARD, Kevin, R. ,  DIEGELMANN, Robert ,  SPIESS, Bruce ,  HUVARD, Gary, S. ,  SANDHU, Gurbhagat, S. ,  BOWLIN, Gary ,  STERN, Chris

IPC分类号： A61L15/00

CPC分类号： A61L15/20 ,  A61F13/00063 ,  A61F13/069 ,  A61F2013/00153 ,  A61F2013/00157 ,  A61F2013/0017 ,  A61F2013/00246 ,  A61F2013/00285 ,  A61F2013/00468 ,  A61F2013/00519 ,  A61F2013/00646 ,  A61F2013/00906 ,  A61F2013/00919 ,  A61K9/1271 ,  A61K33/00 ,  A61L15/44 ,  A61L2300/11 ,  A61L2300/114 ,  A61L2300/608

摘要： This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perf luorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue.