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公开(公告)号：EP2109613A2
公开(公告)日：2009-10-21
申请号：EP07759283.0
申请日：2007-03-23
IPC分类号： C07D487/04 , A61K31/4985 , A61P25/20
摘要： The present invention provides crystalline Eszopiclone malate form II, crystalline Eszopiclone form V, processes from preparing the crystalline Eszopiclone malate form II or V, pharmaceutical compositions comprising the crystalline Eszopiclone malate form II or V and methods of treating insomnia comprising administering the crystalline Eszopiclone malate form II or V.
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2.发明公开
公开(公告)号：EP1828098A1
公开(公告)日：2007-09-05
申请号：EP06844518.8
申请日：2006-11-22
IPC分类号： C07C211/30 , A61K31/137 , A61P5/14
CPC分类号： C07C211/30 , A61K31/137
摘要： Provided are crystalline forms of cinacalcet HCl.
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公开(公告)号：EP1720876A1
公开(公告)日：2006-11-15
申请号：EP05723683.8
申请日：2005-02-25
发明人： WIZEL, Shlomit , ARONHIME, Judith , NIDDAM-HILDESHEIM, Valerie , DOLITZKY, Ben-Zion , ETINGER, Marina, Yu , YUZEFOVICH, Michael , NISNEVICH, Gennady, A. , PERTSIKOV, Boris , TISHIN, Boris , BLASBERGER, Dina
IPC分类号： C07D473/18 , A61K31/522 , A61P31/18
CPC分类号： A61K31/522 , C07D473/00 , C07D473/18
摘要： Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.
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公开(公告)号：EP1392303A2
公开(公告)日：2004-03-03
申请号：EP02733966.2
申请日：2002-04-08
IPC分类号： A61K31/445 , C07D211/22 , C07D211/34
CPC分类号： C07D211/22
摘要： The present invention provides novel crystal forms of fexofenadine hydrochloride Forms (V, VI and VIII through XV) and processes for their preparation and preparation of amorphous form and other crystalline forms of fexofenadine hydrochloride. Forms (XIV and XV) are solvates of ethyl acetate, while Form IX is anhydrous, but can be crystallized as solvate of MTBE or cyclohexane. The forms are useful for administration to humans and animals to alleviate symptoms caused by histamine. The present invention further provides pharmaceutical compositions of the new crystalline forms.
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公开(公告)号：EP1370549A1
公开(公告)日：2003-12-17
申请号：EP02714893.1
申请日：2002-02-14
发明人： METZGER, Leonid , WIZEL, Shlomit
IPC分类号： C07D401/04 , C07D487/12
CPC分类号： C07D401/04 , C07D471/14
摘要： The preparation of 1-(3-carboxypyridyl-2)-4 methyl-2-phenylpiperazine dihydrate and other mirtazapine intermediates are described. These compounds are particularly useful in the preparation of mirtazapine.
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公开(公告)号：EP1881954B1
公开(公告)日：2009-09-16
申请号：EP06760041.1
申请日：2006-05-16
发明人： LIFSHITZ-LIRON, Revital , EISENSTADT, Amihai , WIZEL, Shlomit , AVHAR-MAYDAN, Sharon , RAIZI, Yuriy , RAMATY, Revital
IPC分类号： C07C209/08 , C07C209/22 , C07C211/30
CPC分类号： C07C209/08 , C07B2200/07 , C07C209/16 , C07C209/22 , C07C211/30
摘要： Processes for preparing cinacalcet are provided.
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7.发明公开
公开(公告)号：EP1781611A1
公开(公告)日：2007-05-09
申请号：EP06772705.7
申请日：2006-06-09
发明人： LIFSHITZ, Igor , WIZEL, Shlomit
IPC分类号： C07D209/88
CPC分类号： C07D209/88
摘要： This invention relates to a novel crystalline form of carvedilol, to processes for its preparation, to compositions containing it and to its use in medicine. This invention further relates to a novel process for preparing crystalline carvedilol Form II.
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8.发明公开CRYSTALLINE VENLAFAXINE BASE AND NOVEL POLYMORPHS OF VENLAFAXINE HYDROCHLORIDE, PROCESSES FOR PREPARING THEREOF 审中-公开晶体和盐酸文拉法辛新文拉法辛多晶型，用于生产
公开(公告)号：EP1474379A2
公开(公告)日：2004-11-10
申请号：EP02791279.9
申请日：2002-11-20
IPC分类号： C07C211/00
CPC分类号： C07C217/74 , C07C213/10 , C07C2601/14
摘要： The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochloric acid.
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公开(公告)号：EP1471911A1
公开(公告)日：2004-11-03
申请号：EP03760424.6
申请日：2003-06-16
IPC分类号： A61K31/4725 , C07D215/56
CPC分类号： C07D215/56 , C07D401/04
摘要： Provided are two novel crystalline forms of gatifloxacin, denominated form O and form V, methods for their preparation and pharmaceutical compositions thereof.
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公开(公告)号：EP1467735B1
公开(公告)日：2008-12-10
申请号：EP02805215.7
申请日：2002-12-18
发明人： LIFSHITZ-LIRON, Revital , KOVALEVSKI-ISHAI, Eti , WIZEL, Shlomit , AVHAR-MAYDAN, Sharon , LIDOR-HADAS, Rami
IPC分类号： C07D495/04 , A61K31/44 , A61P9/00
CPC分类号： C07D495/04
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