专利检索 ap:("Teva Pharmaceuticals USA, Inc.") AND inv:"BURGOS, Alain" 第 1 页

1.

发明公开
IMPROVED PROCESS FOR THE SYNTHESIS OF INDANYLAMINE OR AMINOTETRALIN DERIVATIVES AND NOVEL INTERMEDIATES 审中-公开
标题翻译：改进方法合成INDANYLAMIN-和AMINOTETRALINDERIVATEN和新中间体的

公开(公告)号：EP1797030A1

公开(公告)日：2007-06-20

申请号：EP05794146.0

申请日：2005-09-07

申请人： Teva Pharmaceuticals USA, Inc.

发明人： BLANCHET, Sylvie , BLANDINE, Bertrand , BURGOS, Alain , DERRIEN, Yvon , MOREAU, Marie-Laure

IPC分类号： C07C251/64 , C07C231/10 , C07C233/23

CPC分类号： C07C213/02 , C07C231/08 , C07C231/10 , C07C233/23 , C07C251/64 , C07C251/66

摘要： A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the presence of an organic anhydride with subsequent hydrolysis is described. The process is commercially feasible providing indanylamine and aminotetralin derivatives in high yield that are useful as intermediates in the production of therapeutically active compounds. Also described are novel intermediates, 1-indanone O-acetyl oximes and 1-tetralone O-acetyl oximes.