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公开(公告)号：EP0833646A1
公开(公告)日：1998-04-08
申请号：EP96917939.0
申请日：1996-06-03
申请人： The Administrators of The Tulane Educational Fund , THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , The Louisiana State University Medical Center Foundation , CHILDREN'S HOSPITAL, INC.
发明人： COY, David, H. , WOLTERING, Eugene, A. , O'DORISIO, M., Sue , O'DORISIO, Thomas, M. , MURPHY, William, A.
CPC分类号： C07K14/655 , A61K38/00
摘要： Disclosed are methods and compositions for the diagnosis and treatment of diseases associated with aberrant expression of a somatostatin receptor (e.g., cancer) or with increased production of a factor regulatable by somatostatin (e.g., acromegaly). The compounds of the invention are of the general formulae: a) (Y)n+1P, b) (Y)n-Ala-Y-P, or c) (I), wherein P is a somatostatin peptide analog which binds to a somatostatin receptor, Y is D-tyrosine, L-tyrosine, or desamino-tyrosine, n is an integer from 1 to 32, inclusive, each q, independently, is an integer from 1 to 32, inclusive, and each s, independently, is an integer from 1 to 32, inclusive, where q and s can be the same or different, and X is of the formula D-NH2-CH(CH2)mNH2-CO2H or L-NH2-CH(CH2)mNH2-CO2H, wherein m is an integer from 1 to 10, inclusive.
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公开(公告)号：EP0833646B1
公开(公告)日：1999-12-01
申请号：EP96917939.9
申请日：1996-06-03
申请人： The Administrators of The Tulane Educational Fund , THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , The Louisiana State University Medical Center Foundation , CHILDREN'S HOSPITAL, INC.
发明人： COY, David, H. , WOLTERING, Eugene, A. , O'DORISIO, M., Sue , O'DORISIO, Thomas, M. , MURPHY, William, A.
CPC分类号： C07K14/655 , A61K38/00
摘要： Disclosed are methods and compositions for the diagnosis and treatment of diseases associated with aberrant expression of a somatostatin receptor (e.g., cancer) or with increased production of a factor regulatable by somatostatin (e.g., acromegaly). The compounds of the invention are of the general formulae: a) (Y)n+1P, b) (Y)n-Ala-Y-P, or c) (I), wherein P is a somatostatin peptide analog which binds to a somatostatin receptor, Y is D-tyrosine, L-tyrosine, or desamino-tyrosine, n is an integer from 1 to 32, inclusive, each q, independently, is an integer from 1 to 32, inclusive, and each s, independently, is an integer from 1 to 32, inclusive, where q and s can be the same or different, and X is of the formula D-NH2-CH(CH2)mNH2-CO2H or L-NH2-CH(CH2)mNH2-CO2H, wherein m is an integer from 1 to 10, inclusive.
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