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1.发明公开
公开(公告)号：EP4219760A3
公开(公告)日：2023-09-06
申请号：EP23156882.5
申请日：2009-11-10
Applicant: Battelle Memorial Institute , The Institute for Systems Biology , The Ohio State University Research Foundation
Inventor： GALAS, David , GELINAS, Richard, Evan , MARSH, Clay, Braden , PIPER, Melissa, Garnet , WANG, Kai , ZHANG, Shile
IPC: C12Q1/6883 , C12Q1/6886
Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.
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公开(公告)号：EP2364367B8
公开(公告)日：2017-08-23
申请号：EP09760657.8
申请日：2009-11-10
Applicant: Battelle Memorial Institute , Institute for Systems Biology , The Ohio State University Research Foundation
Inventor： GALAS, David , GELINAS, Richard, Evan , MARSH, Clay, Braden , PIPER, Melissa, Garnet , WANG, Kai , ZHANG, Shile
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q1/6827 , C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , C12Q2600/178
Abstract: Methods, compositions, and devices are disclosed which use microRNA to detect, predict, treat, and monitor physiological conditions such as disease or injury. microRNA are isolated and their differential expression is measured to provide diagnostic information. This information may then be utilized for evaluation and/or treatment purposes.
Abstract translation: 公开了使用微RNA来检测，预测，治疗和监测诸如疾病或损伤的生理状况的方法，组合物和装置。 分离microRNA并测量其差异表达以提供诊断信息。 该信息然后可以用于评估和/或治疗目的。
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公开(公告)号：EP2642856B1
公开(公告)日：2017-07-19
申请号：EP11843945.4
申请日：2011-11-21
Inventor： CHEN, Ching-shih , LEE, Su-lin , KULP, Samuel, K.
IPC: A01N43/56 , A61K31/415
CPC classification number: C07D231/14 , C07D231/12
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4.发明授权SYNTHESIS OF SMALL AND NARROW DIAMETER DISTRIBUTED CARBON SINGLE-WALLED NANOTUBES 有权小尺寸和窄尺寸分布碳单壁纳米管的合成
公开(公告)号：EP1794354B1
公开(公告)日：2017-06-14
申请号：EP05858518.3
申请日：2005-09-09
Inventor： HARUTYUNYAN, Avetik , FERNANDEZ, Elena Mora , TOKUNE, Toshio
IPC: C01B32/159 , C01B32/162 , B82Y30/00 , B82Y40/00 , D01F9/127
CPC classification number: C01B32/162 , B82Y30/00 , B82Y40/00 , C01B2202/02 , C01B2202/36 , D01F9/127 , D01F9/1272
Abstract: Method and processes for synthesizing single-wall carbon nanotubes is provided. A carbon precursor gas is contacted with metal catalysts deposited on a support material. The metal catalysts are preferably nanoparticles having diameters less than about 50nm. The reaction temperature is selected such that it is near the eutectic point of the mixture of metal catalyst particles and carbon.
Abstract translation: 提供了用于合成单壁碳纳米管的方法和工艺。 碳前体气体与沉积在载体材料上的金属接触。 金属催化剂优选是直径小于约50nm的纳米粒子。 选择反应温度使其接近金属催化剂颗粒和碳的混合物的共晶点。
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5.发明公开COBALT-FREE, GALLING AND WEAR RESISTANT AUSTENITIC STAINLESS STEEL HARD-FACING ALLOY 审中-公开无钴，耐磨，耐磨奥氏体不锈钢硬面合金
公开(公告)号：EP3158098A1
公开(公告)日：2017-04-26
申请号：EP15809942.4
申请日：2015-06-19
Inventor： SMITH, Ryan, Thomas , LOLLA, Tapasvi , BABU, Sudarsanam, Suresh , GANDY, David, Wayne , SIEFERT, John, Albert , GREGORY, J. Frederick , LHERBIER, Lou , NOVOTNAK, David
Abstract: A strain-hardenable stainless steel alloy includes hard secondary phases dispersed in an austenitic primary phase, the alloy including 0.3-0.6% nitrogen by weight.
Abstract translation: 应变硬化不锈钢合金包括分散在奥氏体初级相中的硬质次生相，所述合金包含0.3-0.6重量％的氮。
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Patent Agency Ranking6.发明公开
公开(公告)号：EP3138926A3
公开(公告)日：2017-04-05
申请号：EP16184406.3
申请日：2008-09-08
Inventor： CROCE, Carlo, M.
IPC: C12Q1/68 , A61K31/7088 , A61P35/00
CPC classification number: C12Q1/6886 , A61K31/7088 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/16 , C12Q2600/178
Abstract: The present invention provides novel methods for the diagnosis of ovarian cancer using at least one miR selected from miR-200b, miR-141, miR-199a, miR-140, miR-145 and miR-125b1miR-200c. The invention also provides methods of identifying anti-ovarian cancer agents and a kit for detecting ovarian cancer.
Abstract translation: 本发明提供了使用miR-200c诊断卵巢癌的新方法。 本发明还提供鉴定抗癌剂的方法。
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公开(公告)号：EP3138926A2
公开(公告)日：2017-03-08
申请号：EP16184406.3
申请日：2008-09-08
Inventor： CROCE, Carlo, M.
IPC: C12Q1/68 , A61K31/7088 , A61P35/00
CPC classification number: C12Q1/6886 , A61K31/7088 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/154 , C12Q2600/16 , C12Q2600/178
Abstract: The present invention provides novel methods for the diagnosis of ovarian cancer using at least one miR selected from miR-200b, miR-141, miR-199a, miR-140, miR-145 and miR-125b1miR-200c. The invention also provides methods of identifying anti-ovarian cancer agents and a kit for detecting ovarian cancer.
Abstract translation: 本发明提供了使用选自miR-200b，miR-141，miR-199a，miR-140，miR-145和miR-125b1miR-200c的至少一个miR诊断卵巢癌的新方法。 本发明还提供了鉴定抗卵巢癌药剂和用于检测卵巢癌的药盒的方法。
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8.发明授权Methods related to microrna-21 and mismatch repair in colorectal cancer 有权与微小RNA-21和结肠直肠癌中Inkongruenzbehebung连接的方法
公开(公告)号：EP2637673B1
公开(公告)日：2016-10-26
申请号：EP11840508.3
申请日：2011-11-11
Inventor： CROCE, Carlo, M. , VALERI, Nicola
IPC: G01N33/574 , C12N15/113 , A61K31/7105 , A61K31/513
CPC classification number: C12N15/1135 , A61K31/513 , A61K31/7088 , A61K31/713 , C12N15/113 , C12Q1/6886 , C12Q2600/112 , G01N33/57419 , G01N2800/52 , G01N2800/56 , A61K2300/00
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9.发明授权MICRO RNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF GASTRIC CANCER 有权对胃癌诊断中的微RNA为基础的方法和组合物
公开(公告)号：EP2257647B1
公开(公告)日：2016-09-14
申请号：EP09713926.5
申请日：2009-02-27
Inventor： CROCE, Carlo, M. , PETROCCA, Fabio , VECCHIONE, Andrea
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12N15/113 , C12N2310/141 , C12Q2525/205 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/178
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10.发明授权MiRNA Expression in Human Peripheral Blood Microvesicles and uses Thereof 有权MiRNA-expression bei humanen Mikrovesikeln in peripherem Blut und Verwendungen davon
公开(公告)号：EP2610342B1
公开(公告)日：2016-05-04
申请号：EP13161709.4
申请日：2008-09-12
Inventor： Marsh, Clay B. , Piper, Melissa G , Ismail, Noura
CPC classification number: C12Q1/6886 , C12N15/111 , C12N15/113 , C12N2310/141 , C12N2320/12 , C12Q1/6809 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12Q2563/161 , C12Q2525/207
Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of disorders by examining samples containing microvesicles and miRs therein.
Abstract translation: 本发明通过检查其中含有微泡和miR的样品，提供用于诊断，预后和治疗疾病的新方法和组合物。
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