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公开(公告)号：EP2831221A1
公开(公告)日：2015-02-04
申请号：EP13713844.2
申请日：2013-03-27
申请人： The Arizona Board Of Regents On Behalf Of The University of Arizona , Université de Luxembourg , Centre de Recherche Public - Gabriel Lippmann
CPC分类号： C12M25/02 , B32B37/1292 , B32B38/1841 , B32B2307/726 , B32B2369/00 , C12M23/16 , C12M29/04 , C12M35/08 , C12N5/0693 , C12N2502/70
摘要： Cell culture apparatus comprising at least two adjacent cell cultivation channels separated by a permeable or semipermeable membrane, wherein at least one channel, for the majority of its length, has a cross sectional area of no more than 1 mm
2 , said channel being provided with entrance and exit means to permit the passage of media therethrough, allows co-culture of separate cell types,
e.g. human and microbial cells, without mingling, allowing monitoring of cell cultures and chemical exchanges between the respective cell cultures.-
公开(公告)号：EP3289066A1
公开(公告)日：2018-03-07
申请号：EP16725161.0
申请日：2016-05-27
CPC分类号： C12M23/16 , C12M3/04 , C12M3/065 , C12M21/08 , C12M23/06 , C12M29/04 , C12M29/12 , C12M35/08
摘要： Cell culture apparatus for emulating gastrointestinal tract conditions and comprising at least two adjacent, microfluidic, cell cultivation channels separated by a permeable or semipermeable membrane, a first channel carrying gastrointestinal tract epithelial cells or tissues and a second channel carrying luminal and preferably mucosal microbiota, and wherein said second channel comprises one or more dwell chambers capable of providing a location for unattached luminal flora to reside away from any direct flow in said second channel, permits modelling of multiple sections of the gastrointestinal tract and control of retention times.
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