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公开(公告)号：EP2283028A2
公开(公告)日：2011-02-16
申请号：EP08797529.8
申请日：2008-08-08
申请人： The Board of Regents of The University of Texas System , Universidade Federal Do Rio De Janeiro
发明人： PASQUALINI, Renata , ARAP, Wadih , GIORDANO, Ricardo , CARDO-VILA, Marina , VALENTE, Ana Paula , CENEVIVA LACERDA DE ALMEIDA, Fabio
IPC分类号： C07K5/08
CPC分类号： C12N15/62 , A61K47/66 , B82Y5/00 , C07K5/0806 , C07K5/0808 , C07K5/0817 , C07K7/06 , C07K7/08 , C07K14/001
摘要： The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly
D (LPR), that selectively target VEGFR-1 and NRP-1 expressing cells. Targeted molecules in accordance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.摘要翻译： 本发明涉及治疗剂的分子医学和靶向递送领域。 更具体地说，本发明涉及鉴定选择性靶向VEGFR-1和NRP-1表达细胞的结合了氨基酸Leu-Pro-Arg（LPR），特别是D（LPR）的新肽序列。 根据本发明的靶向分子可用于治疗和检测新生血管或血管生成性VEGF相关病症，包括但不限于癌症，肥胖症，糖尿病，哮喘，关节炎，肝硬化和眼部疾病。
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公开(公告)号：EP2758421A1
公开(公告)日：2014-07-30
申请号：EP12833225.1
申请日：2012-09-20
IPC分类号： C07K14/00
CPC分类号： A61K47/48246 , A61K47/64 , C07K14/70503 , C12N9/6424
摘要： Systems and reagents for identification, characterization and/or targeting of particular tissue or cell markers are disclosed. Methods and compositions for in vivo and in vitro targeting of particular targets are also disclosed. Peptides are employed for targeted delivery of therapeutic or imaging agents.
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3.发明授权
公开(公告)号：EP2009990B1
公开(公告)日：2016-09-21
申请号：EP07760348.8
申请日：2007-04-09
发明人： PASQUALINI, Renata , ARAP, Wadih , GELOVANI, Juri , MARINI, Frank, C., III , HAJITOU, Amin , ALAUDDIN, Mian , TREPEL, Martin
CPC分类号： A61K47/6455 , A61K47/62 , A61K47/6901 , A61K48/00 , C12N15/86 , C12N2750/14143 , C12N2750/14145 , C12N2795/14143 , C12N2810/405 , C12N2810/85
摘要： Embodiments of the invention are generally directed to compositions and methods of delivering one or more transgene to a target cell, such as a tumor cell, in a site-specific manner to achieve enhanced expression and to constructs and compositions useful in such applications. In certain aspects, expression from a therapeutic nucleic acid may be assessed prior to administration of a treatment or diagnostic procedure to or on a subject.
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公开(公告)号：EP2756002A2
公开(公告)日：2014-07-23
申请号：EP12831898.7
申请日：2012-09-14
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/28 , A61K41/0038 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/33 , C07K2317/56 , C07K2317/73 , C07K2317/76
摘要： The present invention provides compositions and methods for treating a cancer associated with elevated expression and/or activity of receptor typrosine kinases (e.g., Eph receptors), such as EphA5. In some embodiments, the present invention provides compositions and methods for identifying elevated expression or activity of receptor tyrosine kinases (e.g., Eph receptors), such as EphA5.
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5.发明公开COMPOSITIONS AND METHODS RELATED TO PROFILING A PLURALITY OF CELL LINES BASED ON PEPTIDE BINDING 审中-公开组合物和方法与多种细胞系的轮廓连接上肽结合BASE
公开(公告)号：EP2002036A2
公开(公告)日：2008-12-17
申请号：EP07758295.5
申请日：2007-03-09
IPC分类号： C40B40/02 , C40B30/06 , G01N33/574
CPC分类号： C07K7/64 , C07K7/06 , C12N15/1037 , G01N33/57492
摘要： Methods and compositions are described for classifying cells and/or peptides that associate or bind with a particular characteristic pattern to a plurality of cells or cell lines. Aspects of the invention also include the use of peptide(s) having an appropriate binding characteristic to deliver a drug to a cell or cell population.
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公开(公告)号：EP2303913A2
公开(公告)日：2011-04-06
申请号：EP09767865.0
申请日：2009-06-19
发明人： ARAP, Wadih , MINTZ, Paul, J. , PASQUALINI, Renata
CPC分类号： C07K14/7055 , A61K47/62 , C07K2319/01
摘要： Provided are methods and compositions for selectively targeting CRKL through the use of targeting peptides. Selective targeting of secreted CRKL through the use of a targeting peptide may be used, for example, in the treatment of cancer to deliver a chemotherapeutic compound, fusion protein, or fusion construct to a cancer cell or tissue.
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7.发明公开
公开(公告)号：EP2009990A2
公开(公告)日：2009-01-07
申请号：EP07760348.8
申请日：2007-04-09
发明人： PASQUALINI, Renata , ARAP, Wadih , GELOVANI, Juri , MARINI, Frank, C., III , HAJITOU, Amin , ALAUDDIN, Mian , TREPEL, Martin
CPC分类号： A61K47/6455 , A61K47/62 , A61K47/6901 , A61K48/00 , C12N15/86 , C12N2750/14143 , C12N2750/14145 , C12N2795/14143 , C12N2810/405 , C12N2810/85
摘要： Embodiments of the invention are generally directed to compositions and methods of delivering one or more transgene to a target cell, such as a tumor cell, in a site-specific manner to achieve enhanced expression and to constructs and compositions useful in such applications. In certain aspects, expression from a therapeutic nucleic acid may be assessed prior to administration of a treatment or diagnostic procedure to or on a subject.
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