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公开(公告)号：EP2635111B1
公开(公告)日：2018-05-23
申请号：EP11838898.2
申请日：2011-11-04
发明人： DEISSEROTH, Karl , YIZHAR, Ofer , FENNO, Lief
IPC分类号： A01K67/027 , C07K14/405 , G01N33/50
CPC分类号： A01K67/0275 , A01K2217/206 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/405 , C12N5/0619 , C12N2740/16043 , C12N2750/14143 , G01N33/5088 , G01N33/5091
摘要： Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to selectively depolarize neurons residing in microcircuits of the pre-frontal cortex to affect one or more social behaviors, communications, and/or conditioned behaviors in the non-human animal.
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公开(公告)号：EP3486253A1
公开(公告)日：2019-05-22
申请号：EP18212473.5
申请日：2011-11-04
IPC分类号： C07K14/405 , C12N15/62 , C12N5/10 , A01K67/027
摘要： Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
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公开(公告)号：EP2635109A2
公开(公告)日：2013-09-11
申请号：EP11838864.4
申请日：2011-11-04
发明人： DEISSEROTH, Karl , TYE, Kay , FENNO, Lief
IPC分类号： A01K67/027
CPC分类号： A61K38/177 , A01K67/0275 , A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/0356 , A01K2267/0393 , A61B5/165 , A61K9/0019 , A61K41/00 , A61K48/0058 , A61K49/0004 , A61K49/0008 , A61N5/062 , C07K14/705 , C12N7/00 , C12N15/8509 , C12N15/86 , C12N2015/859 , C12N2750/14143 , C12N2799/025 , G01N33/5088
摘要： Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein illumination of the light-responsive opsin proteins causes anxiety in the animal. Also provided herein are methods for alleviating and inducing anxiety in an animal as well as methods for screening for a compound that alleviates anxiety in an animal.
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公开(公告)号：EP2635108A2
公开(公告)日：2013-09-11
申请号：EP11838855.2
申请日：2011-11-04
IPC分类号： A01K67/027
CPC分类号： C07K14/405 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/0393 , A61K38/00 , A61N5/06 , A61N2005/0663 , C07K19/00 , C07K2319/00 , C07K2319/60 , C12N13/00 , G01N33/5058 , G01N2500/10
摘要： Provided herein are compositions comprising light-activated chimeric proteins expressed on plasma membranes and methods of using the same to selectively depolarize excitatory or inhibitory neurons.
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公开(公告)号：EP2635108B1
公开(公告)日：2019-01-23
申请号：EP11838855.2
申请日：2011-11-04
IPC分类号： G01N33/50 , C07K14/405 , C12N15/62 , C12N5/10 , A01K67/027
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公开(公告)号：EP2635111A2
公开(公告)日：2013-09-11
申请号：EP11838898.2
申请日：2011-11-04
发明人： DEISSEROTH, Karl , YIZHAR, Ofer , FENNO, Lief
IPC分类号： A01K67/027
CPC分类号： A01K67/0275 , A01K2217/206 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C07K14/405 , C12N5/0619 , C12N2740/16043 , C12N2750/14143 , G01N33/5088 , G01N33/5091
摘要： Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to selectively depolarize neurons residing in microcircuits of the pre-frontal cortex to affect one or more social behaviors, communications, and/or conditioned behaviors in the non-human animal.
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