专利检索 ap:("The Board of Trustees of the Leland Stanford Junior University") AND inv:"SHI, Haibin" 第 1 页

1.

发明公开
6,7-TRANS CEPHALOSPORIN-BASED PROBES FOR DETECTING BACTERIA EXPRESSING A METALLO- -LACTAMASE 审中-公开
标题翻译： 6,7-反式 - 头孢菌素-BASED传感器，用于细菌的用于表达的金属-β-内酰胺酶检测

公开(公告)号：EP3094623A1

公开(公告)日：2016-11-23

申请号：EP15737920.7

申请日：2015-01-15

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： RAO, Jianghong , SHI, Haibin

IPC分类号： C07D221/00 , C07D501/14 , C07D498/00

CPC分类号： C07D501/00 , C12Q1/34 , C12Q1/66 , G01N2333/986

摘要： The present invention discloses a probe useful for the selective detection of metallo-beta-lactamases, in particular carbapenemases, thereby distinguishing those species of bacteria that are carbapenem-resistant from bacterial strains that are sensitive. Cephalospori based probes that have the 6,7 R,R configuration are susceptible to cleavage by beta-lactamases but cannot distinguish between cleavage by metallo-beta-lactamases and other beta-lactamases. By modifying a side group of the cephalosporin, selectivity can be introduced allowing the probes to distinguish between various types of metallo-beta-lactamases,