公开(公告)号：EP4434992A1

公开(公告)日：2024-09-25

申请号：EP22894936.8

申请日：2022-11-18

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： ZHANG, Yinsheng ,  REN, Jing ,  WANG, Jinan ,  XU, Sheng ,  YANG, Xiaojun ,  DENG, Li ,  HUANG, Yongkang ,  WANG, Qinglin

IPC分类号： C07D498/04 ,  C07D498/00 ,  C07D491/04 ,  A61K31/423 ,  A61K31/343 ,  A61K31/4523 ,  A61K31/4525 ,  A61P35/00 ,  A61P37/00

CPC分类号： A61K31/343 ,  A61K31/423 ,  A61K31/4523 ,  A61K31/4525 ,  A61P35/00 ,  A61P37/00 ,  C07D491/04 ,  C07D498/00 ,  C07D498/04

摘要： Provided are a fused imide derivative as shown in formula I, a preparation method therefor, a pharmaceutical composition containing same, and the use thereof in the treatment of relevant diseases (such as cancers).

公开(公告)号：EP4349838A1

公开(公告)日：2024-04-10

申请号：EP22810368.5

申请日：2022-05-12

申请人： Jiangsu Tasly Diyi Pharmaceutical Co., Ltd.

发明人： SONG, Li ,  TANG, Hai ,  MA, Xiaohui ,  ZHOU, Shuiping ,  CAI, Jinyong ,  DONG, Liming ,  SONG, Zhuang

IPC分类号： C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D519/00 ,  C07D498/00 ,  C07D491/107 ,  C07D491/04 ,  A61K31/519 ,  A61P35/00

摘要： Provided are a new class of compounds having a WEE1 inhibitory effect and as represented by formula I, and the use thereof in the preparation of a drug.

公开(公告)号：EP3563849A2

公开(公告)日：2019-11-06

申请号：EP19172666.0

申请日：2013-10-22

申请人： The General Hospital Corporation

发明人： ELMALEH, David R.

IPC分类号： A61K31/4162 ,  A61K31/70 ,  C07D471/00 ,  C07D498/00 ,  C07H5/02 ,  C07H17/00 ,  A61P25/28 ,  A61P25/00

摘要： The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits AB peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with Tau or alpha-synuclein; or regulates amyloid peptide washout.

公开(公告)号：EP1689746B1

公开(公告)日：2019-01-09

申请号：EP04811266.8

申请日：2004-11-12

申请人： BASF SE

发明人： HE, Yingxia ,  CAMPBELL, Colin Dennis ,  SCHILLING, Gordian ,  CARTER, Rhonda

IPC分类号： C07D471/00 ,  C07D491/00 ,  C07D498/00 ,  C07D513/00 ,  C07D515/00 ,  C08K3/20 ,  C08K5/34 ,  C08K5/48 ,  C08K9/00 ,  C08L25/00 ,  C09B67/22 ,  C09B67/04 ,  C09B67/52

公开(公告)号：EP3094623A1

公开(公告)日：2016-11-23

申请号：EP15737920.7

申请日：2015-01-15

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： RAO, Jianghong ,  SHI, Haibin

IPC分类号： C07D221/00 ,  C07D501/14 ,  C07D498/00

CPC分类号： C07D501/00 ,  C12Q1/34 ,  C12Q1/66 ,  G01N2333/986

摘要： The present invention discloses a probe useful for the selective detection of metallo-beta-lactamases, in particular carbapenemases, thereby distinguishing those species of bacteria that are carbapenem-resistant from bacterial strains that are sensitive. Cephalospori based probes that have the 6,7 R,R configuration are susceptible to cleavage by beta-lactamases but cannot distinguish between cleavage by metallo-beta-lactamases and other beta-lactamases. By modifying a side group of the cephalosporin, selectivity can be introduced allowing the probes to distinguish between various types of metallo-beta-lactamases,

公开(公告)号：EP2814830A1

公开(公告)日：2014-12-24

申请号：EP13704125.7

申请日：2013-02-15

申请人： F.Hoffmann-La Roche AG

发明人： CASTANEDO, Georgette ,  FENG, Jianwen ,  MONTALBETTI, Christian A.G.N. ,  STABEN, Steven

IPC分类号： C07D498/00 ,  C07D498/04 ,  C07D498/12 ,  A61K31/553 ,  A61P25/00

CPC分类号： C07D498/04 ,  C07D487/04 ,  C07D498/00 ,  C07D498/12 ,  C07D513/04 ,  C07D519/00

摘要： The invention relates to novel compounds of Formula I: wherein A
1 , A
2 , A
3 , A
4 , A
5 , A
6 , R
2 , R
4 , R
5 , R
6 , R
7 , R
8 and subscripts m and n each has the meaning as described herein. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.

公开(公告)号：EP2744788A1

公开(公告)日：2014-06-25

申请号：EP12825316.8

申请日：2012-08-13

申请人： Merck Sharp & Dohme Corp.

发明人： ANAND, Rajan ,  COLANDREA, Vincent, J. ,  REITER, Maud ,  VACHAL, Petr ,  ZWICKER, Aaron ,  WILSON, Jonathan, E. ,  ZHANG, Fengqi ,  ZHAO, Kake

IPC分类号： C07D243/00 ,  C07D498/00 ,  C07D487/00

CPC分类号： C07D409/06 ,  A61K31/498 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D241/42 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D405/04 ,  C07D405/06

摘要： Compounds having the structure of Formula Ia, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and may be useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.

摘要翻译： 具有式Ia结构的化合物（包括所述化合物的药学上可接受的盐）是CETP抑制剂，并且可用于提高HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。

公开(公告)号：EP2592932A2

公开(公告)日：2013-05-22

申请号：EP11807175.2

申请日：2011-07-11

申请人： Addex Pharma SA ,  Merck Sharp & Dohme Corp.

发明人： JONES, Philip ,  TANG, Lam ,  BOLEA, Christelle ,  CELANIRE, Sylvain ,  LIVERTON, Nigel, J.

IPC分类号： A01N43/00 ,  C07D498/00 ,  C07D513/00 ,  C07D515/00

CPC分类号： C07D513/12 ,  A23L5/00 ,  A61B5/00 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/10 ,  A61K9/2059 ,  A61K31/429 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/55 ,  A61K45/06 ,  C07D513/04 ,  C07D513/14 ,  A61K2300/00

摘要： The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR
4 ") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR
4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR
4 is involved.

公开(公告)号：EP1233956A4

公开(公告)日：2006-07-05

申请号：EP00982401

申请日：2000-11-30

申请人： UNIV LELAND STANFORD JUNIOR

发明人： WENDER PAUL A ,  LIPPA BLAISE ,  PARK CHEOL-MIN ,  HINKLE KEVIN W

IPC分类号： A61K31/365 ,  A61K31/39 ,  A61P35/00 ,  A61P37/00 ,  A61P37/06 ,  C07D265/12 ,  C07D309/10 ,  C07D309/12 ,  C07D311/96 ,  C07D319/08 ,  C07D327/06 ,  C07D493/06 ,  C07D493/08 ,  C07D493/16 ,  C07D493/18 ,  C07D493/22 ,  C07D497/18 ,  C07D497/22 ,  C07D323/00 ,  A61K31/335 ,  A61K31/35 ,  A61K31/385 ,  A61K31/535 ,  C07D498/00

CPC分类号： C07D493/06 ,  C07D265/12 ,  C07D309/12 ,  C07D319/08 ,  C07D493/08

公开(公告)号：EP1102751A4

公开(公告)日：2005-06-22

申请号：EP99939698

申请日：1999-08-05

申请人： UNIV GEORGETOWN

发明人： KOZIKOWSKI ALAN P ,  SMITH MILES P

IPC分类号： C07D487/08 ,  A61K31/437 ,  A61K31/46 ,  A61P1/14 ,  A61P3/04 ,  A61P15/10 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P43/00 ,  C07D451/02 ,  C07D471/08 ,  C07D471/18 ,  C07D487/18 ,  C07D221/02 ,  C07D215/36 ,  C07D221/22 ,  C07D453/00 ,  C07D455/00 ,  C07D491/00 ,  C07D498/00 ,  C07D513/00

CPC分类号： C07D451/02 ,  C07D471/08