公开(公告)号：EP3097926B1

公开(公告)日：2019-10-02

申请号：EP16175274.6

申请日：2008-11-03

申请人： The Board of Trustees of the University of Arkansas ,  The Texas A&M University System ,  University of Guelph

发明人： BOTTJE, Walter ,  HARGIS, Billy ,  BERGHMAN, Luc ,  KWON, Young, Min ,  COLE, Kimberly ,  COX, Mandy ,  LAYTON, Sherryll ,  EL-ASHRAM, Saeed ,  BARTA, John ,  TELLEZ, Guillermo

IPC分类号： A61K39/012 ,  A61K38/04

公开(公告)号：EP3097926A1

公开(公告)日：2016-11-30

申请号：EP16175274.6

申请日：2008-11-03

申请人： The Board of Trustees of the University of Arkansas ,  The Texas A&M University System ,  University of Guelph

发明人： BOTTJE, Walter ,  HARGIS, Billy ,  BERGHMAN, Luc ,  KWON, Young, Min ,  COLE, Kimberly ,  COX, Mandy ,  LAYTON, Sherryll ,  EL-ASHRAM, Saeed ,  BARTA, John ,  TELLEZ, Guillermo

IPC分类号： A61K39/012 ,  A61K38/04

摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.

摘要翻译： 提供包含TRAP多肽和包含TRAP多肽的肠炎沙门氏杆菌载体的疫苗。 疫苗还可以包括能够结合CD40的CD154多肽。 还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。

公开(公告)号：EP2214701B1

公开(公告)日：2016-08-03

申请号：EP08843740.5

申请日：2008-11-03

申请人： The Board of Trustees of the University of Arkansas ,  The Texas A&M University System ,  University of Guelph

发明人： BOTTJE, Walter ,  HARGIS, Billy ,  BERGHMAN, Luc ,  KWON, Young, Min ,  COLE, Kimberly ,  COX, Mandy ,  LAYTON, Sherryll ,  EL-ASHRAM, Saeed ,  BARTA, John ,  TELLEZ, Guillermo

IPC分类号： A61K39/012 ,  A61K38/04

CPC分类号： A61K39/002 ,  A61K2039/523 ,  A61K2039/53 ,  C07K14/455 ,  C07K14/70575 ,  C07K2319/03 ,  Y02A50/412

摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.

公开(公告)号：EP2214701A2

公开(公告)日：2010-08-11

申请号：EP08843740.5

申请日：2008-11-03

申请人： The Board of Trustees of The University of Arkansas ,  The Texas A&M University System ,  UNIVERSITY OF GUELPH

发明人： BOTTJE, Walter ,  HARGIS, Billy ,  BERGHMAN, Luc ,  KWON, Young, Min ,  COLE, Kimberly ,  COX, Mandy ,  LAYTON, Sherryll ,  EL-ASHRAM, Said ,  BARTA, John ,  TELLEZ, Guillermo

IPC分类号： A61K39/012 ,  A61K38/04

CPC分类号： A61K39/002 ,  A61K2039/523 ,  A61K2039/53 ,  C07K14/455 ,  C07K14/70575 ,  C07K2319/03 ,  Y02A50/412

摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.

公开(公告)号：EP2066339B1

公开(公告)日：2014-08-13

申请号：EP07842706.9

申请日：2007-09-18

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  The Texas A&M University System

发明人： BOTTJE, Walter ,  HARGIS, Billy ,  BERGHMAN, Luc ,  KWON, Young, Min ,  COLE, Kimberly ,  COX, Mandy ,  LAYTON, Sherryll

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/112 ,  A61K49/00 ,  C12P1/00 ,  C12P21/06 ,  C12N1/00 ,  C12N15/00 ,  C12N15/74 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K39/145 ,  A61K35/74 ,  A61K39/00 ,  A61K39/0275 ,  A61K39/12 ,  A61K2035/11 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/6006 ,  A61K2039/6031 ,  C07H21/04 ,  C12N15/102 ,  C12N2760/16134 ,  Y02A50/482

摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.

公开(公告)号：EP2214840B1

公开(公告)日：2015-05-06

申请号：EP08832781.2

申请日：2008-10-30

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  THE TEXAS A&M UNIVERSITY SYSTEM

发明人： BOTTJE, Walter ,  HARGIS, Billy ,  BERGHMAN, Luc ,  KWON, Young, Min ,  COLE, Kimberly ,  COX, Mandy ,  LAYTON, Sherryll

IPC分类号： A61K39/02

CPC分类号： A61K39/0275 ,  A61K2039/522 ,  A61K2039/552 ,  Y02A50/482

摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.

公开(公告)号：EP2066339A2

公开(公告)日：2009-06-10

申请号：EP07842706.9

申请日：2007-09-18

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS

发明人： BOTTJE, Walter ,  HARGIS, Billy ,  BERGHMAN, Luc ,  KWON, Young, Min ,  COLE, Kimberly ,  COX, Mandy ,  LAYTON, Sherryll

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/112 ,  A61K49/00 ,  C12P1/00 ,  C12P21/06 ,  C12N1/00 ,  C12N15/00 ,  C12N15/74 ,  C07H21/02 ,  C07H21/04

CPC分类号： A61K39/145 ,  A61K35/74 ,  A61K39/00 ,  A61K39/0275 ,  A61K39/12 ,  A61K2035/11 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/552 ,  A61K2039/55516 ,  A61K2039/6006 ,  A61K2039/6031 ,  C07H21/04 ,  C12N15/102 ,  C12N2760/16134 ,  Y02A50/482

摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.

公开(公告)号：EP2214840A1

公开(公告)日：2010-08-11

申请号：EP08832781.2

申请日：2008-10-30

申请人： Board of Trustees of the University of Arkansas ,  The Texas A&m University System A Texas State Agency

发明人： BOTTJE, Walter ,  HARGIS, Billy ,  BERGHMAN, Luc ,  KWON, Young, Min ,  COLE, Kimberly ,  COX, Mandy ,  LAYTON, Sherryll

IPC分类号： B05D5/12 ,  H01L21/00

CPC分类号： A61K39/0275 ,  A61K2039/522 ,  A61K2039/552 ,  Y02A50/482

摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.