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公开(公告)号：EP2066339B1
公开(公告)日：2014-08-13
申请号：EP07842706.9
申请日：2007-09-18
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll
IPC分类号： A61K39/00 , A61K39/02 , A61K39/112 , A61K49/00 , C12P1/00 , C12P21/06 , C12N1/00 , C12N15/00 , C12N15/74 , C07H21/02 , C07H21/04
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
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公开(公告)号：EP3097926B1
公开(公告)日：2019-10-02
申请号：EP16175274.6
申请日：2008-11-03
申请人： The Board of Trustees of the University of Arkansas , The Texas A&M University System , University of Guelph
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll , EL-ASHRAM, Saeed , BARTA, John , TELLEZ, Guillermo
IPC分类号： A61K39/012 , A61K38/04
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3.发明公开COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA 审中-公开ZUSAMMENSETZUNGEN UND VERFAHREN ZURVERSTÄRKUNGVON IMMUNREAKTIONENGEGENÜBEREIMERIA
公开(公告)号：EP3097926A1
公开(公告)日：2016-11-30
申请号：EP16175274.6
申请日：2008-11-03
申请人： The Board of Trustees of the University of Arkansas , The Texas A&M University System , University of Guelph
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll , EL-ASHRAM, Saeed , BARTA, John , TELLEZ, Guillermo
IPC分类号： A61K39/012 , A61K38/04
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译： 提供包含TRAP多肽和包含TRAP多肽的肠炎沙门氏杆菌载体的疫苗。 疫苗还可以包括能够结合CD40的CD154多肽。 还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。
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公开(公告)号：EP2214701B1
公开(公告)日：2016-08-03
申请号：EP08843740.5
申请日：2008-11-03
申请人： The Board of Trustees of the University of Arkansas , The Texas A&M University System , University of Guelph
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll , EL-ASHRAM, Saeed , BARTA, John , TELLEZ, Guillermo
IPC分类号： A61K39/012 , A61K38/04
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
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5.发明授权COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO FLAGELLATED BACTERIUM 有权组合物和方法，提高了免疫反应FLAGELLATBAKTERIEN
公开(公告)号：EP2214840B1
公开(公告)日：2015-05-06
申请号：EP08832781.2
申请日：2008-10-30
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll
IPC分类号： A61K39/02
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
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公开(公告)号：EP2214701A2
公开(公告)日：2010-08-11
申请号：EP08843740.5
申请日：2008-11-03
申请人： The Board of Trustees of The University of Arkansas , The Texas A&M University System , UNIVERSITY OF GUELPH
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll , EL-ASHRAM, Said , BARTA, John , TELLEZ, Guillermo
IPC分类号： A61K39/012 , A61K38/04
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
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公开(公告)号：EP2579901A2
公开(公告)日：2013-04-17
申请号：EP11793174.1
申请日：2011-06-09
IPC分类号： A61K48/00
CPC分类号： A61K39/12 , A61K39/105 , A61K2039/523 , A61K2039/53 , A61K2039/55516 , C07K14/205
摘要： Vaccine vectors and methods for enhancing resistance to Campylobacter infection or for enhancing the immune response to Campylobacter are provided herein. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from SEQ ID NO 7-9 or a fragment thereof. The vector may also include an immunostimulatory polypeptide. The methods include administering the vaccine vectors to a subject.
摘要翻译： 本文提供了用于增强对弯曲杆菌感染的抗性或用于增强对弯曲杆菌的免疫应答的疫苗载体和方法。 疫苗载体包括编码选自SEQ ID NO：7-9的抗原性多肽或其片段的第一多核苷酸。 载体还可以包含免疫刺激性多肽。 该方法包括将疫苗载体施用于受试者。
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公开(公告)号：EP2579901B1
公开(公告)日：2019-08-07
申请号：EP11793174.1
申请日：2011-06-09
IPC分类号： A61K39/02 , C07K14/205
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公开(公告)号：EP2066339A2
公开(公告)日：2009-06-10
申请号：EP07842706.9
申请日：2007-09-18
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll
IPC分类号： A61K39/00 , A61K39/02 , A61K39/112 , A61K49/00 , C12P1/00 , C12P21/06 , C12N1/00 , C12N15/00 , C12N15/74 , C07H21/02 , C07H21/04
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
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10.发明公开COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO FLAGELLATED BACTERIUM 有权组合物和方法，提高了免疫反应FLAGELLATBAKTERIEN
公开(公告)号：EP2214840A1
公开(公告)日：2010-08-11
申请号：EP08832781.2
申请日：2008-10-30
申请人： Board of Trustees of the University of Arkansas , The Texas A&m University System A Texas State Agency
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
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