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公开(公告)号：EP2066339B1
公开(公告)日：2014-08-13
申请号：EP07842706.9
申请日：2007-09-18
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll
IPC分类号： A61K39/00 , A61K39/02 , A61K39/112 , A61K49/00 , C12P1/00 , C12P21/06 , C12N1/00 , C12N15/00 , C12N15/74 , C07H21/02 , C07H21/04
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
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2.发明公开COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA OR LIMITING EIMERIA INFECTION 审中-公开组合物和方法免疫反应对抗艾美球虫属的加强或艾美耳球虫感染限制
公开(公告)号：EP2956165A1
公开(公告)日：2015-12-23
申请号：EP14751914.4
申请日：2014-02-14
发明人： BARTA, John, R. , BERGHMAN, Luc , BIELKE, Lisa , HARGIS, Billy , SHIVARAMAIAH, Srichaitanya , FAULKNER, Olivia, B.
IPC分类号： A61K39/002 , A61K39/012 , C12N15/00
CPC分类号： A61K39/002 , A61K39/012 , A61K39/015 , A61K2039/523 , A61K2039/53 , A61K2039/542 , A61K2039/55 , A61K2039/552 , A61K2039/55583 , C07K14/445
摘要： Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or morality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
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公开(公告)号：EP2525817B8
公开(公告)日：2017-09-20
申请号：EP11735230.2
申请日：2011-01-21
发明人： BERGHMAN, Luc , BOTTJE, Walter , HARGIS, Billy , LAYTON, Sherryll
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/6006 , C12N7/00 , C12N2760/16034
摘要： Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
摘要翻译： 本文提供疫苗载体，其包含存在于疫苗载体表面上的抗原性多肽和HMGB1多肽。 还提供了包含疫苗载体的组合物，其包含药学上可接受的载体，合适地为用于口服或鼻腔给药的载体。 还提供了通过将本文公开的疫苗载体或组合物给予受试者来增强免疫应答，特别是抗体免疫应答和合适的IgA应答的方法。
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公开(公告)号：EP2525817A1
公开(公告)日：2012-11-28
申请号：EP11735230.2
申请日：2011-01-21
发明人： BERGHMAN, Luc , BOTTJE, Walter , HARGIS, Billy , LAYTON, Sherryll
IPC分类号： A61K39/145
CPC分类号： A61K39/145 , A61K39/12 , A61K48/00 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/6006 , C12N7/00 , C12N2760/16034
摘要： Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
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公开(公告)号：EP3578190A1
公开(公告)日：2019-12-11
申请号：EP19173788.1
申请日：2014-03-14
发明人： BIELKE, Lisa , LAYTON, Sherryll , HARGIS, Billy , PUMFORD, Neil R. , FAULKNER, Olivia B. , BERGHMAN, Luc , ABI-GHANEM, Daad
摘要： Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
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6.发明授权
公开(公告)号：EP2956165B1
公开(公告)日：2019-09-11
申请号：EP14751914.4
申请日：2014-02-14
发明人： BARTA, John, R. , BERGHMAN, Luc , BIELKE, Lisa , HARGIS, Billy , SHIVARAMAIAH, Srichaitanya , FAULKNER, Olivia, B.
IPC分类号： A61K39/002 , A61K39/012 , C12N15/00
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7.发明公开
公开(公告)号：EP3452069A1
公开(公告)日：2019-03-13
申请号：EP17793221.7
申请日：2017-05-03
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8.发明公开ANTIBODY GUIDED VACCINES AND METHODS OF USE FOR GENERATION OF RAPID MATURE IMMUNE RESPONSES 审中-公开制导抗体疫苗和方法中使用快速轮胎免疫反应的产生
公开(公告)号：EP3151858A2
公开(公告)日：2017-04-12
申请号：EP15802830.8
申请日：2015-06-04
发明人： BERGHMAN, Luc , CHEN, Chang-Hsin , CHOU, Wen-Ko , VUONG, Christine , WAGHELA, Suryakant , MWANGI, Waithaka , HARGIS, Billy , ABI-GHANEM, Daad , BIELKE, Lisa
IPC分类号： A61K39/395
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/0048 , A61K9/0056 , A61K9/08 , A61K9/10 , A61K39/145 , A61K47/36 , A61K47/6881 , A61K2039/505 , A61K2039/5252 , A61K2039/54 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K2039/55516 , A61K2039/575 , A61K2039/6056 , A61K2039/6087 , A61K2039/625 , C07K16/1018 , C07K16/1282 , C07K16/2878 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/76 , G01N33/6878
摘要： Adjuvant compositions, vaccines, constructs for preparing the adjuvant compositions and vaccines and methods of using the adjuvant compositions and vaccines to enhance immune responses in subjects are provided herein. In particular, a rapid antibody response to the vaccine including both IgG (in the circulation) and sIgA (mucosal secretory IgA) is elicited. The adjuvants and vaccines may be used for sub-cutaneous or mucosal administration enabling low cost, effective vaccination of subjects. A method of epitope mapping to rapidly identify antigenic epitopes is also provided.
摘要翻译： 助剂组合物，疫苗，构建了准备佐剂和疫苗组合物和使用佐剂组合物和疫苗，以增强个体的免疫应答中提供的方法。 特别地，快速抗体响应于所述疫苗包含两种IgG的（在循环中）和分泌型IgA（粘膜分泌型IgA）被引出。 佐剂和疫苗可用于皮下或粘膜给药使成本低，受试者有效接种。 因此，提供的表位作图的方法快速识别的抗原表位。
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9.发明公开COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO ENTERIC PATHOGENS 审中-公开增强对肠道病原体免疫应答的组合物和方法
公开(公告)号：EP2968423A1
公开(公告)日：2016-01-20
申请号：EP14769698.3
申请日：2014-03-14
发明人： BIELKE, Lisa , LAYTON, Sherryll , HARGIS, Billy , PUMFORD, Neil R. , FAULKNER, Olivia B. , BERGHMAN, Luc , ABI-GHANEM, Daad
IPC分类号： A61K35/74
CPC分类号： A61K39/0275 , A61K39/0258 , A61K39/105 , A61K39/107 , A61K2039/523 , A61K2039/53 , C07K16/1232 , C07K2317/34 , C12N15/85 , Y02A50/472 , Y02A50/474 , Y02A50/482
摘要： Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD154 polypeptide or an HMGB1 polypeptide.
摘要翻译： 提供了能够引发对肠细菌的免疫应答的疫苗载体和使用它的方法。 疫苗载体包括编码PAL多肽的多核苷酸。 PAL多肽可以在疫苗载体的表面上表达。 疫苗载体还可以包含编码免疫刺激性多肽例如CD154多肽或HMGB1多肽的第二多肽。
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10.发明公开
公开(公告)号：EP3610887A1
公开(公告)日：2020-02-19
申请号：EP19194676.3
申请日：2014-02-14
发明人： BARTA, John R. , BERGHMAN, Luc , BIELKE, Lisa , HARGIS, Billy , SHIVARAMAIAH, Srichaitanya , FAULKNER, Olivia B.
IPC分类号： A61K39/002 , A61K39/012 , C12N15/00 , A61P31/04
摘要： Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
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