公开(公告)号：EP3615538A1

公开(公告)日：2020-03-04

申请号：EP18790880.1

申请日：2018-04-26

申请人： The Brigham and Women's Hospital, Inc. ,  The United States of America, as Represented by The Department of Health and Human Services

发明人： YU, Paul, B. ,  HUANG, Wenwei ,  SANDERSON, Philip, Edward ,  JIANG, Jian-kang ,  SHAMIM, Khalida ,  ZHENG, Wei ,  HUANG, Xiuli ,  TAWA, Gregory ,  LEE, Arthur ,  ALIMARDANOV, Asaf ,  HUANG, Junfeng

IPC分类号： C07D487/04 ,  C07D487/08 ,  C07D471/10 ,  C07D471/04 ,  C07D487/00 ,  C07D487/10 ,  C07D495/04 ,  C07D491/056 ,  C07D519/00 ,  A61K31/519 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/439 ,  A61K31/4365 ,  A61K31/4355 ,  A61P19/08 ,  A61P19/02 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P43/00

公开(公告)号：EP4374928A2

公开(公告)日：2024-05-29

申请号：EP24155493.0

申请日：2018-04-26

申请人： The Brigham And Women's Hospital Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： YU, Paul B. ,  HUANG, Wenwei ,  SANDERSON, Paul B. ,  JIANG, Jian-kang ,  SHAMIM, Khalida ,  ZHENG, Wei ,  HUANG, Xiuli ,  TAWA, Gregory ,  LEE, Arthur ,  ALIMARDANOV, Asaf ,  HUANG, Junfeng

IPC分类号： A61P43/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61P35/04 ,  A61P35/00 ,  A61P37/00 ,  A61P19/02 ,  A61P43/00 ,  A61P19/08 ,  A61K45/06

摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren's syndrome, or diffuse intrinsic pontine glioma (DIPG).

公开(公告)号：EP4374928A3

公开(公告)日：2024-08-14

申请号：EP24155493.0

申请日：2018-04-26

申请人： The Brigham And Women's Hospital Inc. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： YU, Paul B. ,  HUANG, Wenwei ,  SANDERSON, Paul B. ,  JIANG, Jian-kang ,  SHAMIM, Khalida ,  ZHENG, Wei ,  HUANG, Xiuli ,  TAWA, Gregory ,  LEE, Arthur ,  ALIMARDANOV, Asaf ,  HUANG, Junfeng

IPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00 ,  A61K31/519 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/439 ,  A61K31/4365 ,  A61K31/4355 ,  A61P19/08 ,  A61P19/02 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P43/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61P35/04 ,  A61P35/00 ,  A61P37/00 ,  A61P19/02 ,  A61P43/00 ,  A61P19/08 ,  A61K45/06

摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren's syndrome, or diffuse intrinsic pontine glioma (DIPG).