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公开(公告)号：EP4374928A2
公开(公告)日：2024-05-29
申请号：EP24155493.0
申请日：2018-04-26
申请人： The Brigham And Women's Hospital Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： YU, Paul B. , HUANG, Wenwei , SANDERSON, Paul B. , JIANG, Jian-kang , SHAMIM, Khalida , ZHENG, Wei , HUANG, Xiuli , TAWA, Gregory , LEE, Arthur , ALIMARDANOV, Asaf , HUANG, Junfeng
IPC分类号： A61P43/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61P35/04 , A61P35/00 , A61P37/00 , A61P19/02 , A61P43/00 , A61P19/08 , A61K45/06
摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren's syndrome, or diffuse intrinsic pontine glioma (DIPG).
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公开(公告)号：EP4374928A3
公开(公告)日：2024-08-14
申请号：EP24155493.0
申请日：2018-04-26
申请人： The Brigham And Women's Hospital Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Services
发明人： YU, Paul B. , HUANG, Wenwei , SANDERSON, Paul B. , JIANG, Jian-kang , SHAMIM, Khalida , ZHENG, Wei , HUANG, Xiuli , TAWA, Gregory , LEE, Arthur , ALIMARDANOV, Asaf , HUANG, Junfeng
IPC分类号： C07D487/04 , C07D471/04 , C07D519/00 , A61K31/519 , A61K31/4375 , A61K31/438 , A61K31/439 , A61K31/4365 , A61K31/4355 , A61P19/08 , A61P19/02 , A61P35/00 , A61P35/04 , A61P37/00 , A61P43/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00 , A61P35/04 , A61P35/00 , A61P37/00 , A61P19/02 , A61P43/00 , A61P19/08 , A61K45/06
摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren's syndrome, or diffuse intrinsic pontine glioma (DIPG).
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3.发明授权
公开(公告)号：EP2920161B1
公开(公告)日：2019-08-14
申请号：EP13814276.5
申请日：2013-11-14
发明人： MARUGAN, Juan Jose , ZHENG, Wei , XIAO, Jingbo , MCKEW, John
IPC分类号： C07D311/72 , A61K31/555 , A61P43/00 , A61K31/122 , A61K31/35 , A61K31/335 , A61K31/724 , A61K31/355
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4.发明公开TOCOPHEROL AND TOCOPHERYL QUINONE DERIVATIVES AS CORRECTORS OF LYSOSOMAL STORAGE DISORDERS 审中-公开N N N N N N N N N N N N N N N N N N N N N N N N N
公开(公告)号：EP2920161A2
公开(公告)日：2015-09-23
申请号：EP13814276.5
申请日：2013-11-14
发明人： MARUGAN, Juan Jose , ZHENG, Wei , XIAO, Jingbo , MCKEW, John
IPC分类号： C07D311/72 , A61K31/555 , A61P43/00
CPC分类号： C07D311/58 , A61K31/122 , A61K31/335 , A61K31/35 , A61K31/352 , A61K31/353 , A61K31/355 , A61K31/724 , C07C50/02 , C07C50/06 , C07C50/24 , C07D311/72
摘要： The subject invention relates to improved tocopheryl quinone derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some embodiments, be useful in the treatment of Lysosomal Storage Disorders, restoration of normal mitochondrial ATP production, modulation of intracellular calcium ion concentration and other treatments or therapies. The tocopheryl quinone derivatives and tocopherol derivatives have side chains that have terminally halogenated carbon atoms.
摘要翻译： 本发明涉及具有改善的体内药代动力学的改良生育酚醌衍生物和生育酚衍生物，其在一些实施方案中可用于治疗溶酶体贮积障碍，恢复正常的线粒体ATP产生，细胞内钙离子浓度的调节和其它治疗 或治疗。 生育酚醌衍生物和生育酚衍生物具有具有末端卤代碳原子的侧链。
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公开(公告)号：EP4175636A2
公开(公告)日：2023-05-10
申请号：EP21751672.3
申请日：2021-07-01
发明人： HUANG, Wenwei , MONDAL, Anupam , ZHENG, Wei , CHEN, Yu Holly , SWAROOP, Anand , SWAROOP, Manju , TAWA, Gregory , PAPAL, Samantha , LUO, Zhiji
IPC分类号： A61K31/473 , A61K31/475 , A61K31/498 , A61P27/02 , A61K31/137
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公开(公告)号：EP2844345A1
公开(公告)日：2015-03-11
申请号：EP13715054.6
申请日：2013-03-15
申请人： The United States of America, as Represented by The Secretary, Department of Health and Human Services , The Florida International University Board of Trustees
发明人： MARUGAN, Juan Jose , XIAO, Jingbo , FERRER-ALEGRE, Marc , CHEN, Catherine , SOUTHALL, Noel , ZHENG, Wei , AGOULNIK, Alexander , AGOULNIK, Irina
IPC分类号： A61P9/00 , A61K31/167 , A61K31/27 , A61K31/341 , A61K31/381 , A61K31/36 , A61K31/4409 , A61K31/422 , A61K31/277 , A61K31/495 , A61K31/4453 , C07C271/28 , C07C233/63 , C07C237/42 , C07D261/18
CPC分类号： C07D333/38 , C07C233/63 , C07C235/64 , C07C237/30 , C07C237/40 , C07C237/42 , C07C251/24 , C07C255/57 , C07C255/60 , C07C257/04 , C07C257/18 , C07C271/28 , C07C311/29 , C07C317/36 , C07C317/40 , C07C317/44 , C07C323/42 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/08 , C07C2603/74 , C07D209/08 , C07D209/46 , C07D211/26 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D235/06 , C07D235/08 , C07D235/14 , C07D235/18 , C07D257/04 , C07D261/18 , C07D295/088 , C07D295/135 , C07D295/205 , C07D307/52 , C07D307/68 , C07D317/66 , C07D317/68 , C07D333/20 , C07D333/40 , C07D403/10 , C07D487/04
摘要： Disclosed are modulators of the human relaxin receptor 1, for example, of formula (I), wherein A, R1, and R2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e.g., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method for therapeutic intervention in a facet of mammalian health that is mediated by a human relaxin receptor 1.
摘要翻译： 公开了人类松弛素受体1的调节剂，例如式（I）的化合物，其中A，R1和R2如本文所定义，其可用于治疗哺乳动物松弛素受体1介导的人类健康的方面，例如心血管疾病 。 还公开了包含药学上合适的载体和本公开的至少一种化合物的组合物，以及由人松弛素受体1介导的哺乳动物健康方面的治疗性干预的方法。
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公开(公告)号：EP3790878A1
公开(公告)日：2021-03-17
申请号：EP19726848.5
申请日：2019-05-13
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： HUANG, Wenwei , LI, Hao , ZHENG, Wei , SUN, Wei , HUANG, Xiuli , LU, Xiao , SANDERSON, Philip E. , XU, Xin , SHAH, Pranav , WILLIAMSON, Kim C. , LUO, Zhiji , TAWA, Gregory J.
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4353 , A61K31/4375 , A61P33/02
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公开(公告)号：EP3615538A1
公开(公告)日：2020-03-04
申请号：EP18790880.1
申请日：2018-04-26
申请人： The Brigham and Women's Hospital, Inc. , The United States of America, as Represented by The Department of Health and Human Services
发明人： YU, Paul, B. , HUANG, Wenwei , SANDERSON, Philip, Edward , JIANG, Jian-kang , SHAMIM, Khalida , ZHENG, Wei , HUANG, Xiuli , TAWA, Gregory , LEE, Arthur , ALIMARDANOV, Asaf , HUANG, Junfeng
IPC分类号： C07D487/04 , C07D487/08 , C07D471/10 , C07D471/04 , C07D487/00 , C07D487/10 , C07D495/04 , C07D491/056 , C07D519/00 , A61K31/519 , A61K31/4375 , A61K31/438 , A61K31/439 , A61K31/4365 , A61K31/4355 , A61P19/08 , A61P19/02 , A61P35/00 , A61P35/04 , A61P37/00 , A61P43/00
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