公开(公告)号：EP3262193A2

公开(公告)日：2018-01-03

申请号：EP16714607.5

申请日：2016-02-26

申请人： The Broad Institute Inc. ,  Massachusetts Institute of Technology ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  The Regents of the University of California

发明人： REGEV, Aviv ,  KUCHROO, Vijay, K. ,  GAUBLOMME, Jellert ,  LEE, Youjin ,  WANG, Chao ,  YOSEF, Nir ,  PARK, Hongkun ,  KAMINSKI, James

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6881 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/5023

摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.

公开(公告)号：EP3110971B1

公开(公告)日：2019-05-08

申请号：EP15709048.1

申请日：2015-02-26

申请人： The Broad Institute Inc. ,  The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College ,  Massachusetts Institute of Technology

发明人： KUCHROO, Vijay ,  REGEV, Aviv ,  GAUBLOMME, Jellert ,  LEE, Youjin ,  SHALEK, Alexander, K. ,  WANG, Chao ,  YOSEF, Nir ,  PARK, Hongkun

IPC分类号： C12Q1/6883 ,  C07K16/28 ,  G01N33/68

公开(公告)号：EP3110971A2

公开(公告)日：2017-01-04

申请号：EP15709048.1

申请日：2015-02-26

申请人： The Broad Institute Inc. ,  The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College ,  Massachusetts Institute of Technology

发明人： KUCHROO, Vijay ,  REGEV, Aviv ,  GAUBLOMME, Jellert ,  LEE, Youjin ,  SHALEK, Alexander, K. ,  WANG, Chao ,  YOSEF, Nir ,  PARK, Hongkun

IPC分类号： C12Q1/68

CPC分类号： G01N33/6863 ,  C07K16/2866 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/75 ,  C07K2317/76 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.

摘要翻译： 本发明一般涉及用于鉴定调节，控制或以其它方式影响T细胞平衡的调节网络的组合物和方法，例如Th17细胞分化，维持和/或功能，以及用于利用调节网络的组合物和方法， 控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡。 本发明还涉及鉴定和利用调节，控制或以其他方式影响各种治疗和/或诊断适应症中的T细胞平衡的靶基因和/或靶基因产物。

公开(公告)号：EP2961849A2

公开(公告)日：2016-01-06

申请号：EP14715725.9

申请日：2014-02-27

申请人： The Broad Institute, Inc. ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： REGEV, Aviv ,  KUCHROO, Vijay ,  PARK, Hongkun ,  YOSEF, Nir ,  SHALEK, Alexander, K. ,  GAUBLOMME, Jellert ,  JOLLER, Nicole C. ,  WU, Chuan ,  ANDERSON, Ana, Carrizosa

IPC分类号： C12Q1/68 ,  A61K39/39 ,  C12N5/0783

CPC分类号： C12N5/0636 ,  A61K31/12 ,  A61K31/198 ,  A61K31/37 ,  A61K31/4745 ,  A61K31/66 ,  A61K31/661 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/739 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K38/1767 ,  A61K38/1866 ,  A61K38/191 ,  A61K38/363 ,  A61K38/4866 ,  A61K48/00 ,  C07K16/28 ,  C07K2317/76 ,  C12N5/0637 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2501/15 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/2323 ,  C12N2501/25 ,  C12N2501/90 ,  C12Q1/6881 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y304/21069 ,  G01N33/56972 ,  G01N2570/00 ,  G01N2800/56

摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.

公开(公告)号：EP3942023A1

公开(公告)日：2022-01-26

申请号：EP20720562.6

申请日：2020-03-18

申请人： The Broad Institute, Inc. ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  The Brigham & Women's Hospital, Inc. ,  The Regents of the University of California

发明人： REGEV, Aviv ,  WANG, Chao ,  KUCHROO, Vijay K. ,  YOSEF, Nir ,  WAGNER, Allon ,  FESSLER, Johannes

IPC分类号： C12N5/0783 ,  C12N9/10 ,  C12N9/02 ,  A61K31/132 ,  C12N9/88

公开(公告)号：EP3420102A1

公开(公告)日：2019-01-02

申请号：EP17709268.1

申请日：2017-02-22

申请人： Massachusetts Institute of Technology ,  The Regents of the University of California ,  The General Hospital Corporation ,  Shalek, Alexander K. ,  Kolb, Kellie E. ,  Cole, Michael B. ,  Yosef, Nir ,  Gayo, Enrique Martin ,  Ouyang, Zhengyu ,  Yu, Xu

发明人： SHALEK, Alexander, K. ,  KOLB, Kellie, E. ,  COLE, Michael, B. ,  YOSEF, Nir ,  GAYO, Enrique, Martin ,  OUYANG, Zhengyu ,  YU, Xu

IPC分类号： C12Q1/68