公开(公告)号：EP3831923A1

公开(公告)日：2021-06-09

申请号：EP20211221.5

申请日：2020-12-02

申请人： The Charles Stark Draper Laboratory, Inc.

发明人： BORENSTEIN, Jeffrey ,  MOORE, Nathan ,  DOTY, Daniel ,  HAGGERTY, Timothy ,  CHAREST, Joseph ,  GIMBEL, Alla ,  MOTT, Vienna ,  ISENBERG, Brett ,  AZIZGOLSHANI, Hesham ,  CAIN, Brian ,  MESCHER, Mark

IPC分类号： C12M1/32 ,  G01N33/00 ,  B01L3/00 ,  C12M1/00 ,  C12M3/06 ,  C12M1/12

摘要： A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.