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1.发明公开
公开(公告)号：EP4373080A1
公开(公告)日：2024-05-22
申请号：EP24152686.2
申请日：2014-10-24
发明人： HIGH, Katherine A. , BENNETT, Jean , CHUNG, Daniel , MAGUIRE, Albert , WELLMAN, Jennifer , MCCAGUE, Sarah , PODSAKOFF, Gregory
CPC分类号： A61B3/0041 , A61B3/0008 , A61B3/063
摘要： A test of visual function and/or functional vision may be performed at varying luminance levels. A first course may be selected for a subject. A given course may comprise a layout having a beginning point, at least one turn, at least one obstacle, and an ending point. The first course may be illuminated with a first luminance level based on an estimated lower light sensitivity cutoff. The subject may be prompted to perform a first run of the test. The test may comprise, from the beginning point to the ending point, navigating the layout of the first course by walking around the at least one turn and avoiding the at least one obstacle. A determination may be made as to whether the subject successfully completed the first course based on one or both of speed or accuracy.
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2.发明公开APPARATUS AND METHODS FOR TESTING VISUAL FUNCTION AND FUNCTIONAL VISION AT VARYING LUMINANCE LEVELS 审中-公开设备和检验方法的视力并伴有不同LUMINOSITY功能概述
公开(公告)号：EP3061244A1
公开(公告)日：2016-08-31
申请号：EP14855682.2
申请日：2014-10-24
发明人： HIGH, Katherine A. , BENNETT, Jean , CHUNG, Daniel , MAGUIRE, Albert , WELLMAN, Jennifer , MCCAGUE, Sarah , PODSAKOFF, Gregory
CPC分类号： A61B3/063 , A61B3/0008 , A61B3/0041 , A61B5/11 , A61B5/72 , A63B2220/00
摘要： A test of visual function and/or functional vision may be performed at varying luminance levels. A first course may be selected for a subject. A given course may comprise a layout having a beginning point, at least one turn, at least one obstacle, and an ending point. The first course may be illuminated with a first luminance level based on an estimated lower light sensitivity cutoff. The subject may be prompted to perform a first run of the test. The test may comprise, from the beginning point to the ending point, navigating the layout of the first course by walking around the at least one turn and avoiding the at least one obstacle. A determination may be made as to whether the subject successfully completed the first course based on one or both of speed or accuracy.
摘要翻译： 视觉功能和/或功能的视力测试可以以不同亮度水平来执行。 第一过程可以被选择用于受试者。 一个给定的过程可以包括具有起点，至少一圈，至少一个障碍，并结束点的布局。 第一过程可以基于估计在低光灵敏度截止的第一亮度水平被照亮。 受试者可以被提示来执行测试的第一运行。 该测试可能包括，从起点到终点，通过围绕至少一圈走和至少一个回避障碍物航行的第一期培训班的布局。 可以判定做出关于是否受试者基于一个或两个的速度或准确度的成功完成第一过程。
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公开(公告)号：EP3956442A1
公开(公告)日：2022-02-23
申请号：EP20791307.0
申请日：2020-04-17
发明人： FISHER, Krishna, J. , BENNETT, Jean
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公开(公告)号：EP3934699A1
公开(公告)日：2022-01-12
申请号：EP20765810.5
申请日：2020-03-03
发明人： BENNETT, Jean , MCDOUGALD, Devin , SUN, Junwei
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公开(公告)号：EP3630986A1
公开(公告)日：2020-04-08
申请号：EP18810330.3
申请日：2018-05-31
申请人： The Trustees of The University of Pennsylvania , University of Southern California , The Research Institute of the McGill University Health Centre
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公开(公告)号：EP3389724A2
公开(公告)日：2018-10-24
申请号：EP16852859.4
申请日：2016-12-13
CPC分类号： C07K14/47 , A61K48/00 , A61K48/0058 , C12N15/86 , C12N2750/14143 , C12N2800/22
摘要： Compositions and methods are provided for treating ocular disorders in a subject are provided. In one aspect, an adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding CNGA3. In another aspect, an adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding CNGB3. In another aspect, an adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding REP-1. In desired embodiments, the subject is human, cat, dog, sheep, or non-human primate.
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公开(公告)号：EP3481958A1
公开(公告)日：2019-05-15
申请号：EP17824989.2
申请日：2017-07-07
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公开(公告)号：EP2954051B1
公开(公告)日：2019-03-27
申请号：EP14749120.3
申请日：2014-02-07
IPC分类号： C12N7/01 , C12N15/864 , C07K14/015 , A61P27/02
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公开(公告)号：EP3377116A1
公开(公告)日：2018-09-26
申请号：EP16867296.2
申请日：2016-11-18
CPC分类号： C12N15/86 , A61K48/005 , C12N15/00 , C12N2740/10043 , C12N2750/14143
摘要： A nucleic acid trans-splicing molecule is provided that can replace an exon in a targeted mammalian ocular gene carrying a defect or mutation causing an ocular disease with an exon having the naturally-occurring sequence without the defect or mutation. A method of treating an ocular disease, e.g., Stargardt's Disease, caused by a defect or mutation in a target gene, e.g., ABCA4 comprising: administering to the ocular cells of a subject having an ocular disease a composition comprising a recombinant AAV comprising a nucleic acid trans-splicing molecule as described above.
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公开(公告)号：EP3781213A1
公开(公告)日：2021-02-24
申请号：EP19789043.7
申请日：2019-04-17
发明人： JOHNSON, Philip, R. , SCHNEPP, Bruce, C. , BENNETT, Jean , DOOLEY, Scott, J. , FISHER, Krishna, Jawaharlal , SUN, Junwei
IPC分类号： A61K48/00 , C07K14/705
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