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1.发明公开Prolactin inhibiting or stimulating compounds to regulate the immune function 失效催乳素-himende oder -stimulierende Verbindungen zur Regulierung der Immunfunktion
公开(公告)号：EP1275392A2
公开(公告)日：2003-01-15
申请号：EP02017154.2
申请日：1995-07-07
申请人： The General Hospital doing business as Massachusetts General Hospital , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K31/4985 , A61K31/454 , A61P37/02
CPC分类号： A61K38/225 , A61K31/00 , A61K31/137 , A61K31/166 , A61K31/40 , A61K31/405 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/475 , A61K31/48 , A61K31/4985 , A61K31/5415 , A61K38/2257 , A61K45/06 , A61K2300/00
摘要： Methods for rectifying or ameliorating abnormal responses of mammalian immune systems is provided. Also provided are methods for modifying normal responses of the mammalian immune system. Further provided is a method for treating a mammal having an immune dysfunction by administering to the mammal a prolactin reducer and/or enhancer at a predetermined time or times during a 24-hour period that results in modification of the mammal's abnormal prolactin profile so that it approaches or conforms to the prolactin profile of a young mammal of the same species, thereby ameliorating said immune dysfunction. Also provided is a method of upregulating or augmenting an immune response in a mammal.
摘要翻译： 提供了整流或改善哺乳动物免疫系统异常反应的方法。 还提供了用于修饰哺乳动物免疫系统的正常反应的方法。 还提供了一种通过在24小时内给予哺乳动物预定时间或次的哺乳动物减少哺乳动物和/或增强剂来治疗具有免疫功能障碍的哺乳动物的方法，导致哺乳动物的异常催乳素特征的改变， 接近或符合相同物种的年轻哺乳动物的催乳素谱，从而改善所述免疫功能障碍。 还提供了在哺乳动物中上调或增加免疫应答的方法。
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2.发明授权Prolactin inhibiting or stimulating compounds to regulate the immune function 失效催乳素抑制性化合物或-stimulating调节免疫功能
公开(公告)号：EP1275392B1
公开(公告)日：2009-08-26
申请号：EP02017154.2
申请日：1995-07-07
申请人： The General Hospital doing business as Massachusetts General Hospital , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K31/4985 , A61K31/454 , A61P37/02
CPC分类号： A61K38/225 , A61K31/00 , A61K31/137 , A61K31/166 , A61K31/40 , A61K31/405 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/475 , A61K31/48 , A61K31/4985 , A61K31/5415 , A61K38/2257 , A61K45/06 , A61K2300/00
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3.发明公开Prolactin inhibiting or stimulating compounds to regulate the immune function 失效催乳素抑制性化合物或-stimulating调节免疫功能
公开(公告)号：EP1275392A3
公开(公告)日：2003-05-21
申请号：EP02017154.2
申请日：1995-07-07
申请人： The General Hospital doing business as Massachusetts General Hospital , THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IPC分类号： A61K31/4985 , A61K31/454 , A61P37/02
CPC分类号： A61K38/225 , A61K31/00 , A61K31/137 , A61K31/166 , A61K31/40 , A61K31/405 , A61K31/445 , A61K31/4515 , A61K31/454 , A61K31/475 , A61K31/48 , A61K31/4985 , A61K31/5415 , A61K38/2257 , A61K45/06 , A61K2300/00
摘要： Methods for rectifying or ameliorating abnormal responses of mammalian immune systems is provided. Also provided are methods for modifying normal responses of the mammalian immune system. Further provided is a method for treating a mammal having an immune dysfunction by administering to the mammal a prolactin reducer and/or enhancer at a predetermined time or times during a 24-hour period that results in modification of the mammal's abnormal prolactin profile so that it approaches or conforms to the prolactin profile of a young mammal of the same species, thereby ameliorating said immune dysfunction. Also provided is a method of upregulating or augmenting an immune response in a mammal.
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