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1.发明授权METHOD OF MAKING POLYHYDRIC ALCOHOL SOLUTIONS OF ENHANCED EFFICACY ANTIPERSPIRANT ACTIVES 失效PROCESS SOLUTIONS多元醇的止汗剂效率提高CONTAIN
公开(公告)号：EP0789554B1
公开(公告)日：1999-09-22
申请号：EP95939000.6
申请日：1995-10-30
申请人： THE GILLETTE COMPANY
发明人： PROVANCAL, Stephen, J. , CARRILLO, Angel, L. , FLUHLER, Thomas, J. , ORYSZCZAK, Richard , SANE, Jayant, N.
IPC分类号： A61K7/38
摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by (a) providing an aqueous solution consisting essentially of about 5 % to about 18 % by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder; (b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and (c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50 % enhanced efficacy aluminum antiperspirant salt and about 2 to 16 % water, with the balance being polyhydric alcohol. An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.
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公开(公告)号：EP1330232B1
公开(公告)日：2006-08-16
申请号：EP01988579.7
申请日：2001-10-24
申请人： The Gillette Company
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirocnium antiperspirant salt compositions which exhiit an HPLC peak 5 area content of about 33 % or more, preferably at least 45 %, more preferably at least 50 %, most preferably at least 55 %. Especially preferred are aluminum-zirconium antiperspirant salt composition which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al + Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant sald compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminium-zirconium antiperspirant salt composition as described above.
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公开(公告)号：EP1330232A2
公开(公告)日：2003-07-30
申请号：EP01988579.7
申请日：2001-10-24
申请人： The Gillette Company
IPC分类号： A61K7/38
CPC分类号： A61Q15/00 , A61K8/28 , C01G25/006 , C01P2002/87 , Y10S424/05
摘要： Disclosed are enhanced efficacy aluminum-zirocnium antiperspirant salt compositions which exhiit an HPLC peak 5 area content of about 33 % or more, preferably at least 45 %, more preferably at least 50 %, most preferably at least 55 %. Especially preferred are aluminum-zirconium antiperspirant salt composition which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al + Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant sald compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminium-zirconium antiperspirant salt composition as described above.
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4.发明公开
公开(公告)号：EP0728037A1
公开(公告)日：1996-08-28
申请号：EP95901125.0
申请日：1994-11-07
发明人： ROUANET, Stephane, Fabrice , MCGOVERN, William, Edward , CAO, Wanqing , KLOTZ, Irving, M. , CARRILLO, Angel, L. , MOSES, John, M.
CPC分类号： A61Q15/00 , A61K8/042 , A61K8/26 , B01J13/0091
摘要： A method for providing aerogels, and aerogels produced according to the method, is described. As one aspect, antiperspirant compounds that are in aerogel form, and antiperspirant and deodorant compositions including such salts, are described. The method involves contacting a solution containing material to be processed with a species selected to precipitate the material and selected so as to be miscible with the solvent system of the solution. After the material is precipitated, the material may be washed with the precipitating species until it is substantially free of solvent system. Then, the precipitating species containing the material precipitate is taken above its critical point, and the supercritical fluid is exhausted above its critical temperature. Alternately, a separate isolating species is introduced to displace the precipitating species, or the precipitating species/solvent system mixture. The isolating species then is taken above its critical point, and exhausted above its critical temperature. The invention provides for batch or continuous processes.
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5.发明授权
公开(公告)号：EP0728037B1
公开(公告)日：1999-01-13
申请号：EP95901125.5
申请日：1994-11-07
申请人： THE GILLETTE COMPANY
发明人： ROUANET, Stephane, Fabrice , MCGOVERN, William, Edward , CAO, Wanqing , KLOTZ, Irving, M. , CARRILLO, Angel, L. , MOSES, John, M.
CPC分类号： A61Q15/00 , A61K8/042 , A61K8/26 , B01J13/0091
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6.发明公开METHOD OF MAKING POLYHYDRIC ALCOHOL SOLUTIONS OF ENHANCED EFFICACY ANTIPERSPIRANT ACTIVES 失效PROCESS SOLUTIONS多元醇的止汗剂效率提高CONTAIN
公开(公告)号：EP0789554A1
公开(公告)日：1997-08-20
申请号：EP95939000.0
申请日：1995-10-30
申请人： THE GILLETTE COMPANY
发明人： PROVANCAL, Stephen, J. , CARRILLO, Angel, L. , FLUHLER, Thomas, J. , ORYSZCZAK, Richard , SANE, Jayant, N.
摘要： The present invention comprises a process of preparing a solution of an enhanced efficacy aluminum antiperspirant salt in a polyhydric alcohol by (a) providing an aqueous solution consisting essentially of about 5 % to about 18 % by weight of an enhanced efficacy aluminum antiperspirant salt in water, the enhanced efficacy aluminum antiperspirant salt having been prepared in situ without having been dried to a solid powder; (b) mixing the aqueous solution with a sufficient amount of a liquid polyhydric alcohol to provide a mixed solution which has an antiperspirant salt to polyhydric alcohol ratio of about 1:4 to about 1.2:1; and (c) rapidly evaporating the water from the mixed solution under vacuum to provide a final liquid polyhydric alcohol solution containing about 20 to 50 % enhanced efficacy aluminum antiperspirant salt and about 2 to 16 % water, with the balance being polyhydric alcohol. An alkaline glycinate salt, such as sodium, potassium or zinc glycinate, may be added to the polyhydric alcohol prior to the addition of the antiperspirant salt solution in order to raise the pH of the recovered product to about 4.1 to 5.0.
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