公开(公告)号：EP3369828A1

公开(公告)日：2018-09-05

申请号：EP17207095.5

申请日：2012-02-06

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana, O. ,  FANG, Zhichao ,  VASILYEVA, Elizaveta

IPC分类号： C12Q1/6816 ,  C07H21/04 ,  G01N33/50

摘要： Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bio-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.

公开(公告)号：EP2331950A1

公开(公告)日：2011-06-15

申请号：EP09810953.1

申请日：2009-09-01

申请人： The Governing Council Of The University Of Toronto

发明人： SOLEYMANI, Leyla ,  FANG, Zhichao ,  KELLEY, Shana ,  SARGENT, Edward ,  TAFT, Bradford

IPC分类号： G01N27/327 ,  G01N27/30 ,  G01N27/403 ,  G01N27/416 ,  G01N33/53 ,  C12Q1/68 ,  C12Q1/00 ,  C40B60/00

CPC分类号： G01N27/3272 ,  G01N27/30 ,  G01N27/3275 ,  G01N27/3278 ,  G01N33/5438 ,  Y10S977/754 ,  Y10S977/925

摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

摘要翻译： 本文公开了纳米结构微电极和包含该微电极的生物感测装置。

公开(公告)号：EP2331950B1

公开(公告)日：2014-07-23

申请号：EP09810953.1

申请日：2009-09-01

申请人： The Governing Council of the University of Toronto

发明人： SOLEYMANI, Leyla ,  FANG, Zhichao ,  KELLEY, Shana ,  SARGENT, Edward ,  TAFT, Bradford

IPC分类号： G01N27/327 ,  G01N27/30 ,  G01N27/403 ,  G01N27/416 ,  G01N33/53 ,  C12Q1/68 ,  C12Q1/00 ,  C40B60/00 ,  G01N33/543

CPC分类号： G01N27/3272 ,  G01N27/30 ,  G01N27/3275 ,  G01N27/3278 ,  G01N33/5438 ,  Y10S977/754 ,  Y10S977/925

公开(公告)号：EP3369828B1

公开(公告)日：2020-07-15

申请号：EP17207095.5

申请日：2012-02-06

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana, O. ,  FANG, Zhichao ,  VASILYEVA, Elizaveta

IPC分类号： C12Q1/6816 ,  C12Q1/6886 ,  C07H21/04

公开(公告)号：EP2673381A2

公开(公告)日：2013-12-18

申请号：EP12744938.7

申请日：2012-02-06

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana, O. ,  FANG, Zhichao ,  VASILYEVA, Elizaveta

IPC分类号： C12Q1/68 ,  C07H21/04 ,  G01N33/50

CPC分类号： C12Q1/6816 ,  C12N2310/3181 ,  C12Q1/6837 ,  C12Q1/6886 ,  G01N27/26 ,  G01N27/3276 ,  G01N27/3277 ,  C12Q2523/31

摘要： Disclosed are biomolecule based bioprobes that exhibit improved water solubility and monolayer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bio-probe. Further disclosed are suitable electrochemical reporter systems for use with bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.