公开(公告)号：EP4115176A1

公开(公告)日：2023-01-11

申请号：EP21764464.0

申请日：2021-03-02

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana ,  SARGENT, Edward ,  DAS, Jagotamoy ,  GOMIS, Surath ,  CHEN, Jenise B. ,  AHMED, Sharif ,  YOUSEFI, Hanie ,  CHANG, Dingran ,  MAHMUD, Alam

IPC分类号： G01N27/327 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N27/416 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553 ,  G01N33/569 ,  G01N27/403

公开(公告)号：EP2331950B1

公开(公告)日：2014-07-23

申请号：EP09810953.1

申请日：2009-09-01

申请人： The Governing Council of the University of Toronto

发明人： SOLEYMANI, Leyla ,  FANG, Zhichao ,  KELLEY, Shana ,  SARGENT, Edward ,  TAFT, Bradford

IPC分类号： G01N27/327 ,  G01N27/30 ,  G01N27/403 ,  G01N27/416 ,  G01N33/53 ,  C12Q1/68 ,  C12Q1/00 ,  C40B60/00 ,  G01N33/543

CPC分类号： G01N27/3272 ,  G01N27/30 ,  G01N27/3275 ,  G01N27/3278 ,  G01N33/5438 ,  Y10S977/754 ,  Y10S977/925

公开(公告)号：EP2576595B1

公开(公告)日：2016-12-21

申请号：EP11789003.8

申请日：2011-05-27

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana ,  PEREIRA, Mark ,  FONSECA, Sonali

IPC分类号： C07K7/06 ,  A61K47/48 ,  A61P35/00

CPC分类号： A61K47/48 ,  A61K38/00 ,  A61K47/64 ,  A61K47/645 ,  C07K7/06

公开(公告)号：EP2576595A1

公开(公告)日：2013-04-10

申请号：EP11789003.8

申请日：2011-05-27

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana ,  PEREIRA, Mark ,  FONSECA, Sonali

IPC分类号： C07K7/06 ,  A61K47/48 ,  A61P35/00 ,  C07K5/10

CPC分类号： A61K47/48 ,  A61K38/00 ,  A61K47/64 ,  A61K47/645 ,  C07K7/06

摘要： There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an anticancer compound, and their method of use.

摘要翻译： 本文描述了包含缀合至抗癌化合物的线粒体穿透肽（MPP）的化合物及其使用方法。

公开(公告)号：EP2576594A1

公开(公告)日：2013-04-10

申请号：EP11789002.0

申请日：2011-05-27

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana ,  PEREIRA, Mark

IPC分类号： C07K7/06 ,  A61K47/48 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  C07K5/10 ,  A61K31/519

CPC分类号： A61K47/48246 ,  A61K38/08 ,  A61K47/64 ,  A61K47/645 ,  C07K7/06

摘要： There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an antimicrobial, and their method of use.

公开(公告)号：EP3362785A1

公开(公告)日：2018-08-22

申请号：EP16854672.9

申请日：2016-10-14

申请人： University Health Network (UHN) ,  The Governing Council of the University of Toronto

发明人： KESHAVJEE, Shafique ,  LIU, Mingyao ,  SAGE, Andrew ,  SARGENT, Edward ,  KELLEY, Shana

IPC分类号： G01N27/416 ,  G01N27/327 ,  G01N33/543 ,  G01N27/30

CPC分类号： G01N27/3276 ,  B82Y30/00 ,  G01N27/3278 ,  G01N33/5438 ,  G01N33/563 ,  G01N33/566 ,  G01N2800/56 ,  G01N2800/60

摘要： There is described herein a method for the electrochemical quantification of a protein analyte in sample, comprising: providing one or more electrode(s), each comprising at least one peptide attached to its surface, the peptide being the protein or a fragment thereof; contacting the sample and electrode with an antibody in the presence of a redox reporter, wherein the antibody is capable of binding to each of the protein analyte and the peptide on the electrode; measuring an electrochemical signal generated by the redox reporter when a potential is applied; quantifying the protein analyte by comparing the electrochemical signal generated with a control, wherein the electrochemical signal is indirectly proportional to the amount of protein analyte in the sample.

公开(公告)号：EP4184515A1

公开(公告)日：2023-05-24

申请号：EP22199379.3

申请日：2018-08-13

申请人： The Governing Council of the University of Toronto

发明人： LABIB, Mahmoud ,  SARGENT, Edward ,  KELLEY, Shana

IPC分类号： G16B25/00 ,  C12Q1/6841 ,  B01L3/00

摘要： Methods and systems for mRNA analysis and quantification of mRNA expression in cells are provided. An example method includes introducing a first capture probe and a second capture probe into the cells, the first capture probe and the second capture probe each configured to be complementary to a respective section of target mRNA within the cells, wherein binding of the first and second capture probes to the respective sections of the target mRNA results in tagging of the cells and causes the first and second capture probes to form clusters with each other. The first capture probe and the second capture probe are each bound to magnetic nanoparticles (MNPs) that, when trapped within the tagged cells, cause the tagged cells to be susceptible to magnetic forces. The method and system further include introducing the cells into a device configured to magnetically capture tagged cells.

公开(公告)号：EP2576594B1

公开(公告)日：2016-07-13

申请号：EP11789002.0

申请日：2011-05-27

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana ,  PEREIRA, Mark

IPC分类号： C07K7/06 ,  A61K47/48 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  C07K5/10 ,  A61K38/08

CPC分类号： A61K47/48246 ,  A61K38/08 ,  A61K47/64 ,  A61K47/645 ,  C07K7/06

公开(公告)号：EP2331950A1

公开(公告)日：2011-06-15

申请号：EP09810953.1

申请日：2009-09-01

申请人： The Governing Council Of The University Of Toronto

发明人： SOLEYMANI, Leyla ,  FANG, Zhichao ,  KELLEY, Shana ,  SARGENT, Edward ,  TAFT, Bradford

IPC分类号： G01N27/327 ,  G01N27/30 ,  G01N27/403 ,  G01N27/416 ,  G01N33/53 ,  C12Q1/68 ,  C12Q1/00 ,  C40B60/00

CPC分类号： G01N27/3272 ,  G01N27/30 ,  G01N27/3275 ,  G01N27/3278 ,  G01N33/5438 ,  Y10S977/754 ,  Y10S977/925

摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

摘要翻译： 本文公开了纳米结构微电极和包含该微电极的生物感测装置。