公开(公告)号：EP1075660A1

公开(公告)日：2001-02-14

申请号：EP99922892.7

申请日：1999-05-10

申请人： The Johns Hopkins University

发明人： ANDERSON, Charles, W. ,  BARGERON, C., Brent ,  BENSON, Richard, C. ,  CARLSON, Micah, A. ,  FRASER, Alan, B. ,  GROOPMAN, John, D. ,  KO, Harvey, W. ,  KOHLER, David, R. ,  PHILLIPS, Terry, E. ,  STRICKLAND, Paul, T.

IPC分类号： G01N33/536

CPC分类号： G01N1/40 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2400/0481 ,  G01N1/405 ,  G01N21/6428 ,  G01N21/645 ,  G01N30/02 ,  G01N33/54373 ,  G01N33/582 ,  G01N2001/022 ,  G01N2201/0221 ,  B01D15/3804

摘要： A hand-held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined. The rinsing and elution fluids, and/or the affinity column can be placed in a module for easy insertion and removal from the sensor when depleted or when the sensor is to be used against a different analyte.

摘要翻译： 一种手持式，自包含式，自动化，低功耗和快速的传感器平台，用于检测和量化多种分析物。 可能含有未知量分析物的样品溶液通过亲和柱，该柱含有分析物结合的抗体，从而提取分析物。 然后漂洗亲和柱以除去可能发荧光的任何其他化学物质。 然后用已知体积的洗脱液洗脱漂洗过的亲和柱，使分析物从抗体中释放出来并溶解在流体中（洗脱液）。 然后将洗脱液置于荧光计的石英比色杯中。 悬浮在洗脱液中的分析物在不同于激发它的光源的波段处发荧光。 测量荧光量并确定分析物的水平。 清洗和洗脱液和/或亲和柱可放置在模块中，以便在耗尽时或当传感器用于抵抗不同分析物时易于从传感器插入和移除。

公开(公告)号：EP1297553A2

公开(公告)日：2003-04-02

申请号：EP01937673.0

申请日：2001-05-23

申请人： The Johns Hopkins University ,  Ecelberger, Scott, A.

发明人： ANDERSON, Charles, W. ,  SCHOLL, Peter, F. ,  CHAPPELL, Ronald, G. ,  BRYDEN, Wayne, A. ,  KO, Harvey, W.

IPC分类号： H01J49/04 ,  H01J49/40

CPC分类号： H01J49/0445 ,  H01J49/0022 ,  H01J49/40

摘要： A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.

公开(公告)号：EP1295269A2

公开(公告)日：2003-03-26

申请号：EP01948604.2

申请日：2001-06-22

申请人： The Johns Hopkins University

发明人： NAJMI, Amir-Homayoon ,  SMITH, Dexter, G. ,  MCLOUGHLIN, Michael, P. ,  KO, Harvey, W.

IPC分类号： G08B13/16

CPC分类号： G08B13/1672

摘要： Disclosed is a method for detecting unwanted dissemination of aerosolized agents into an HVAC system in a building by detecting the sound of the dissemination at the time it occurs. To be able to distinguish the sound of the dissemination event from the ambient background noise of the HVAC system, sound extraction techniques, e.g., high pass filtering and an adaptive variance estimator, are utilized which can detect the event's noise from within the ambient background noise of the system. A microphone continually monitors background sound levels and senses the additional sound resulting from the activation of the aerosol delivery system, which has a unique sound 'signature'. Once an event is detected, defensive actions, e.g., activating additional sensors, closing all air vents, and shutting off the HVAC system, can be taken.

公开(公告)号：EP0229831A1

公开(公告)日：1987-07-29

申请号：EP86904639.0

申请日：1986-07-11

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： KO, Harvey, W. ,  HART, Lynn, W.

IPC分类号： G01N27 ,  A61B5 ,  G01V3

CPC分类号： G01V3/102 ,  A61B5/053 ,  A61B5/4504

摘要： Un appareil et un procédé sont utilisés pour détecter de manière non-invasive la guérison d'un os. Un enroulement (10) concentre spatialement un champ magnétique autour d'une partie du corps et un détecteur oscillateur (12) détecte des changements d'impédance du site de la fracture pendant le processus de guérison. Les changements d'impédance du site de la fracture constituent une indication directe de la résistance mécanique du site de la fracture.