公开(公告)号：EP2326735A1

公开(公告)日：2011-06-01

申请号：EP09792198.5

申请日：2009-09-03

申请人： The Johns Hopkins University ,  Duke University

发明人： VOGELSTEIN, Bert ,  KINZLER, Kenneth W. ,  PARSONS, D. Williams ,  ZHANG, Xiaosong ,  LIN, Jimmy Chang-Ho ,  LEARY, Rebecca J. ,  ANGENENDT, Philipp ,  PAPADOPOULOS, Nickolas ,  VELCULESCU, Victor ,  PARMIGIANI, Giovanni ,  KARCHIN, Rachel ,  JONES, Sian ,  YAN, Hai ,  BIGNER, Darell ,  KUAN, Chien-Tsun

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156

摘要： We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

公开(公告)号：EP3266879B1

公开(公告)日：2019-07-03

申请号：EP17168866.6

申请日：2009-09-03

申请人： The Johns Hopkins University ,  Duke University

发明人： VOGELSTEIN, Bert ,  KINZLER, Kenneth ,  PAPADOPOULOS, Nickolas ,  VELCULESCU, Victor ,  PARMIGIANI, Giovanni ,  KARCHIN, Rachel ,  JONES, Sian ,  YAN, Hai ,  BIGNER, Darell ,  KUAN, Chien-Tsun ,  RIGGINS, Gregory ,  PARSONS, Williams ,  ZHANG, Xiaosong ,  LIN, Jimmy Cheng-Ho ,  LEARY, Rebecca ,  ANGENENDT, Philipp

IPC分类号： C12Q1/68

公开(公告)号：EP2326735B1

公开(公告)日：2016-11-16

申请号：EP09792198.5

申请日：2009-09-03

申请人： The Johns Hopkins University ,  Duke University

发明人： VOGELSTEIN, Bert ,  KINZLER, Kenneth W. ,  PARSONS, D. Williams ,  ZHANG, Xiaosong ,  LIN, Jimmy Cheng-Ho ,  LEARY, Rebecca J. ,  ANGENENDT, Philipp ,  PAPADOPOULOS, Nickolas ,  VELCULESCU, Victor ,  PARMIGIANI, Giovanni ,  KARCHIN, Rachel ,  JONES, Sian ,  YAN, Hai ,  BIGNER, Darell ,  KUAN, Chien-Tsun ,  RIGGINS, Gregory J.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156

公开(公告)号：EP3266879A1

公开(公告)日：2018-01-10

申请号：EP17168866.6

申请日：2009-09-03

申请人： The Johns Hopkins University ,  Duke University

发明人： VOGELSTEIN, Bert ,  KINZLER, Kenneth ,  PAPADOPOULOS, Nickolas ,  VELCULESCU, Victor ,  PARMIGIANI, Giovanni ,  KARCHIN, Rachel ,  JONES, Sian ,  YAN, Hai ,  BIGNER, Darell ,  KUAN, Chien-Tsun ,  RIGGINS, Gregory ,  PARSONS, Williams ,  ZHANG, Xiaosong ,  LIN, Jimmy Cheng-Ho ,  LEARY, Rebecca ,  ANGENENDT, Philipp

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156

摘要： We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

摘要翻译： 我们在大多数II级和III级星形细胞瘤以及少突胶质细胞瘤以及从这些低级病变发展而来的胶质母细胞瘤中发现异柠檬酸脱氢酶1（IDH1）的R132残基突变。 没有IDH1突变的那些肿瘤通常在密切相关的IDH2基因的类似R172残基处具有突变。 这些发现对于恶性神经胶质瘤的发病机制和诊断具有重要意义。

公开(公告)号：EP2861619A1

公开(公告)日：2015-04-22

申请号：EP13800038.5

申请日：2013-06-07

申请人： Duke University ,  The Government of the United States of America, as represented by The Department of Health and Human Services

发明人： BIGNER, Darell ,  KUAN, Chien-Tsun ,  SAMPSON, John ,  CHOI, Bryan ,  PASTAN, Ira H. ,  GEDEON, Patrick C.

IPC分类号： C07K16/18 ,  C12N15/13 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K16/2809 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/92 ,  C12N15/11

摘要： We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging moleculess are highly cytotoxic and antigen-specific. These are promising therapeutic agents.

公开(公告)号：EP1954720A1

公开(公告)日：2008-08-13

申请号：EP06827329.1

申请日：2006-10-31

申请人： The Government of the United States of America, as Represented by the Secretary of Health and Human Services, National Institutes of Health ,  Duke University

发明人： KUAN, Chien-Tsun ,  BIGNER, Darell, D. ,  PASTAN, Ira, H.

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61P35/00 ,  C12N15/13 ,  A61K47/48 ,  G01N33/68 ,  A61K51/10

CPC分类号： C07K16/28 ,  A61K47/6817 ,  A61K2039/505 ,  C07K16/1214 ,  C07K16/30 ,  C07K2317/565 ,  C12N15/00 ,  G01N33/57484

摘要： The invention provides high affinity antibodies suitable for forming immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells.

公开(公告)号：EP1841782A2

公开(公告)日：2007-10-10

申请号：EP05851831.7

申请日：2005-11-17

申请人： Duke University

发明人： BIGNER, Darell, D. ,  PEGRAM, Charles, N. ,  KUAN, Chien-Tsun

IPC分类号： C07K1/00 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K16/28 ,  C07K16/18 ,  C07K16/30 ,  G01N33/57426 ,  G01N33/57484 ,  G01N33/57492 ,  G01N2333/78

摘要： The present invention provides immunoassays for detecting a tumor in a subject, comprising producing an antibody that specifically binds to tenascin, contacting the antibody with a biological sample suspected of containing tumor cells and determining the binding of the antibody to the biological sample. The present invention further provides methods of identifying a subject for treatment of a tumor. Kits for direct or indirect immunohitochemical or immunocytochemical assays are also provided. A novel polyclonal antibody that binds to tenascin domain TNfn C-D is further provided.

公开(公告)号：EP3019532B1

公开(公告)日：2019-01-02

申请号：EP14823231.7

申请日：2014-07-09

申请人： Duke University ,  The Government of the United States, as represented by The Secretary of the Department of Health and Human Services

发明人： BIGNER, Darell D. ,  SAMPSON, John ,  KUAN, Chien-Tsun ,  CAI, Mingqing ,  CHOI, Bryan D. ,  GEDEON, Patrick C. ,  PASTAN, Ira H.

IPC分类号： C07K16/46 ,  C12N15/13 ,  A61P35/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  A61K39/00

公开(公告)号：EP3019532A1

公开(公告)日：2016-05-18

申请号：EP14823231.7

申请日：2014-07-09

申请人： Duke University ,  The Government of the United States, as represented by The Secretary of the Department of Health and Human Services

发明人： BIGNER, Darell D. ,  SAMPSON, John ,  KUAN, Chien-Tsun ,  CAI, Mingqing ,  CHOI, Bryan D. ,  GEDEON, Patrick C. ,  PASTAN, Ira H.

IPC分类号： C07K16/46 ,  C12N15/13 ,  A61P35/00 ,  A61K39/395

CPC分类号： C07K16/32 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73

摘要： We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The polynucleotide is codon optimized for expression in CHO cells. The subunits of the engaging molecules are organized to achieve greater efficiency. These are therapeutic agents.

摘要翻译： 我们已经构建了编码双特异性抗体接合分子的多核苷酸，其具有特异性地与表达人EGFRvIII突变蛋白的肿瘤细胞特异性结合的一个臂，以及特异性结合T细胞活化配体CD3的第二臂。 多核苷酸经密码子优化用于在CHO细胞中表达。 接合分子的亚基被组织以实现更高的效率。 这些是有希望的治疗剂。