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公开(公告)号:EP3193845A1
公开(公告)日:2017-07-26
申请号:EP15771451.0
申请日:2015-09-18
IPC分类号: A61K9/50 , A61K31/137 , A61P11/02
CPC分类号: A61K31/137 , A61K9/1676 , A61K9/5078 , A61K9/5084
摘要: A multi-particle dosage form that can deliver phenylephrine in controlled pulsed doses. The dosage form can contain an immediate release form that can contain phenylephrine or a salt thereof and a plurality of delayed release particles with a coating that can contain phenylephrine or salt thereof and a pH sensitive coating.
摘要翻译: 可以以受控脉冲剂量递送去氧肾上腺素的多颗粒剂型。 剂型可以含有速释形式,其可以含有去氧肾上腺素或其盐以及具有可以含有去氧肾上腺素或其盐和pH敏感性涂层的涂层的多个延迟释放颗粒。
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公开(公告)号:EP3193844A1
公开(公告)日:2017-07-26
申请号:EP15771450.2
申请日:2015-09-18
IPC分类号: A61K9/50 , A61K31/137
CPC分类号: A61K9/5089 , A61K9/5078 , A61K31/137 , B01J2/16
摘要: Forming a coated core by using a fluidized bed processor that discharges a spray containing atomized air and a coating solution where the coating solution contains an active. Then, wetting the core with the coating solution and drying the wetted cores to form coated cores. These steps can be repeated until an appropriate amount of active has been applied. The coated cores are visually perceived as smooth under a microscope with a total magnification of 40X.
摘要翻译: 通过使用流化床处理器形成涂覆的核心,所述流化床处理器释放含有雾化空气的喷雾和涂层溶液含有活性物质的涂层溶液。 然后,用涂层溶液润湿核心并干燥湿核心以形成涂层核心。 这些步骤可以重复进行,直到适用适量的活性物质。 在总放大倍数为40倍的显微镜下,涂层核心在视觉上感觉平滑。
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公开(公告)号:EP2046289B1
公开(公告)日:2014-01-29
申请号:EP07735602.0
申请日:2007-04-20
发明人: MARTIN, Kelly, Lee , KHANOLKAR, Jayant, Eknath , GLEDHILL, Douglas, William , CRISS, Susan, Elaine , RAMJI, Niranjan , COSTEINES, Elaine, Rose , HUETTER, Thomas, Edward , IYER, Radhika, R. , ANNESS, Daren, K.
IPC分类号: A61K31/137 , A61P11/02
CPC分类号: A61K31/485 , A61J1/05 , A61K9/0095 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/473 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2300/00
摘要: A stable liquid composition in a clear bottle where the composition contains, at least, phenylephrine and acetaminophen. The composition is substantially free of aldehydes and has a pH from 3.5 to 5. The clear bottle is a polyethylene terphthalate bottle.
摘要翻译: 澄清瓶中稳定的液体组合物,其中组合物至少含有去氧肾上腺素和对乙酰氨基酚。 该组合物基本上不含醛,pH值为3.5至5.透明瓶是聚对苯二甲酸乙二醇酯瓶。
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