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公开(公告)号：EP2046289B1
公开(公告)日：2014-01-29
申请号：EP07735602.0
申请日：2007-04-20
发明人： MARTIN, Kelly, Lee , KHANOLKAR, Jayant, Eknath , GLEDHILL, Douglas, William , CRISS, Susan, Elaine , RAMJI, Niranjan , COSTEINES, Elaine, Rose , HUETTER, Thomas, Edward , IYER, Radhika, R. , ANNESS, Daren, K.
IPC分类号： A61K31/137 , A61P11/02
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0095 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/473 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： A stable liquid composition in a clear bottle where the composition contains, at least, phenylephrine and acetaminophen. The composition is substantially free of aldehydes and has a pH from 3.5 to 5. The clear bottle is a polyethylene terphthalate bottle.
摘要翻译： 澄清瓶中稳定的液体组合物，其中组合物至少含有去氧肾上腺素和对乙酰氨基酚。 该组合物基本上不含醛，pH值为3.5至5.透明瓶是聚对苯二甲酸乙二醇酯瓶。
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2.发明授权
公开(公告)号：EP2032129B1
公开(公告)日：2014-01-29
申请号：EP07735601.2
申请日：2007-04-20
发明人： MARTIN, Kelly, Lee , KHANOLKAR, Jayant, Eknath , GLEDHILL, Douglas, William , CRISS, Susan, Elaine , RAMJI, Niranjan , COSTEINES, Elaine, Rose
IPC分类号： A61K31/137 , A61P11/02 , A61K9/00 , A61K47/26
CPC分类号： A61K31/137 , A61K31/473 , A61K31/485 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions including phenylephrine, its free and addition salt forms, and mixtures thereof, alone, or in combination with other pharmaceutical actives. The compositions have a pH of about 2 to about 5 and are substantially free of aldehydes. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its free and addition salt forms, and mixtures thereof alone, or in combination with other pharmaceutical actives, wherein the composition has a pH of from about 2 to about 5 and is substantially free of aldehydes.
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3.发明授权LIQUID COMPOSITIONS COMPRISING PHENYLEPHRINE AND ACETAMINOPHEN AND THEIR USE FOR THE TREATMENT OF RESPIRATORY ILLNESS 有权液体组合物，包含去氧肾上腺素和乙酰氨基酚和它们用于呼吸系统疾病的治疗
公开(公告)号：EP2012765B2
公开(公告)日：2018-04-11
申请号：EP07735699.6
申请日：2007-04-27
IPC分类号： A61K31/137 , A61K31/167 , A61K31/485 , A61K47/10 , A61K47/12 , A61K47/20 , A61P11/02 , A61P11/10
CPC分类号： A61K9/0095 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/485 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K2300/00
摘要： Disclosed are compositions including phenylephrine, its salts, and mixtures thereof, in combination with acetaminophen; and optionally in combination with additional pharmaceutical actives. The compositions have a pH of about 6.5 to about 7.5 and may be substantially free of aldehydes. The invention also provides a method of stabilizing phenylephrine. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its salts, and mixtures thereof, in combination with acteaminophen; and optionally in combination with additional pharmaceutical actives, wherein the composition has a pH of from about 6.5 to about 7.5 and may be substantially free of aldehydes.
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4.发明授权LIQUID COMPOSITIONS COMPRISING PHENYLEPHRINE AND ACETAMINOPHEN AND THEIR USE FOR THE TREATMENT OF RESPIRATORY ILLNESS 有权液体化合物含肾上腺素和ACTETAMINOPHEN及其用于呼吸系统疾病的治疗
公开(公告)号：EP2012765B1
公开(公告)日：2015-03-25
申请号：EP07735699.6
申请日：2007-04-27
IPC分类号： A61K31/137 , A61K31/167 , A61K31/485 , A61K47/10 , A61K47/12 , A61K47/20 , A61P11/02 , A61P11/10
CPC分类号： A61K9/0095 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/485 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K2300/00
摘要： Disclosed are compositions including phenylephrine, its salts, and mixtures thereof, in combination with acetaminophen; and optionally in combination with additional pharmaceutical actives. The compositions have a pH of about 6.5 to about 7.5 and may be substantially free of aldehydes. The invention also provides a method of stabilizing phenylephrine. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its salts, and mixtures thereof, in combination with acteaminophen; and optionally in combination with additional pharmaceutical actives, wherein the composition has a pH of from about 6.5 to about 7.5 and may be substantially free of aldehydes.
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5.发明公开
公开(公告)号：EP2032129A2
公开(公告)日：2009-03-11
申请号：EP07735601.2
申请日：2007-04-20
发明人： MARTIN, Kelly, Lee , KHANOLKAR, Jayant, Eknath , GLEDHILL, Douglas, William , CRISS, Susan, Elaine , RAMJI, Niranjan , COSTEINES, Elaine, Rose
IPC分类号： A61K31/137
CPC分类号： A61K31/137 , A61K31/473 , A61K31/485 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions including phenylephrine, its free and addition salt forms, and mixtures thereof, alone, or in combination with other pharmaceutical actives. The compositions have a pH of about 2 to about 5 and are substantially free of aldehydes. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its free and addition salt forms, and mixtures thereof alone, or in combination with other pharmaceutical actives, wherein the composition has a pH of from about 2 to about 5 and is substantially free of aldehydes.
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