A NONINVASIVE METHOD FOR MEASURING ANTIMICROBIAL PEPTIDES FROM SKIN AS AN OBJECTIVE MEASUREMENT OF NATURAL PROTECTION FROM MICROBES
    4.
    发明公开
    A NONINVASIVE METHOD FOR MEASURING ANTIMICROBIAL PEPTIDES FROM SKIN AS AN OBJECTIVE MEASUREMENT OF NATURAL PROTECTION FROM MICROBES 审中-公开
    从抵御细菌了自然保护皮肤的客观测量测量抗菌肽的非侵入性方法

    公开(公告)号:EP2972328A2

    公开(公告)日:2016-01-20

    申请号:EP14724207.7

    申请日:2014-03-14

    CPC classification number: G01N33/5091 G01N33/6881

    Abstract: A noninvasive method for measuring dandruff in a subject comprising collecting an epithelial cell /skin cell sample from the subject; detecting a level of an antimicrobial peptide biomarkers being human beta-defensin-2 (hBD-2 in the epithelial cell sample/skin cell sample; diagnosing the subject as having dandruff based on the level of human beta-defensin-2 (hBD-2) biomarker and determining the amount of the human beta-defensin-2 (hBD-2) biomarker in the epithelial cells as compared to a normal population. Further, a noninvasive method for evaluating the efficacy of products for dandruff.

    Abstract translation: 用于在受试者中包括收集来自所述受试者上皮细胞/皮肤细胞样品测量皮肤健康的非侵入式方法; 检测的一个或多个抗微生物肽生物标志物的上皮细胞样品/皮肤细胞样品中的水平; 受试者为具有防御机制诊断由于对皮肤微生物攻击或系统与环境稳态余量的基础上的选自组蛋白H2B型的1-M中选择的一种或多种抗微生物肽的生物标志物的水平的量度, 组蛋白H2A,组蛋白H4,蛋白质S100-A7,蛋白S100-A8,蛋白S100-A9,组织蛋白酶G,嗜中性粒细胞防御素3(防卫素,α-3)(HNP-3),Dermcidin,核糖核酸酶7(RNA酶7),人β 防御素2(NBD-2)和β-防卫素103(β防御素3)和表1中的worin AMP家庭列出包括杀菌通透性增加蛋白(BPI),防卫素,组蛋白,成孔毒素,S100蛋白, 细胞毒素丝氨酸蛋白酶51,双氧化酶,转录调节,以及它们的混合物。 此外,对于皮肤健康评估产品的功效的非侵入性方法。

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