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公开(公告)号：EP2668180B1
公开(公告)日：2018-08-01
申请号：EP12739376.7
申请日：2012-01-24
发明人： WANG, Shaomeng , ZHOU, Haibin , CHEN, Jianfang , AGUILAR, Angelo , MEAGHER, Jennifer, Lynn , SUN, Duxin , YANG, Chao-Yie , LIU, Liu , BAI, Longchuan , MCEACHERM, Donna , STUCKEY, Jeanne , LI, Xiaoqin
IPC分类号： C07D403/10 , C07D403/14 , A61K31/496 , A61P35/00
CPC分类号： C07D239/28 , C07D207/34 , C07D231/12 , C07D233/28 , C07D233/56 , C07D261/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
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公开(公告)号：EP2707372A2
公开(公告)日：2014-03-19
申请号：EP12782304.5
申请日：2012-05-11
IPC分类号： C07D487/10 , C07D413/12 , A61K31/407 , A61P35/00
CPC分类号： C07D487/10
摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
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公开(公告)号：EP3600313A1
公开(公告)日：2020-02-05
申请号：EP18776755.3
申请日：2018-03-30
发明人： WANG, Shaomeng , AGUILAR, Angelo , XU, Shilin , HUANG, Liyue , STUCKEY, Jeanne , TIANFENG, Xu
IPC分类号： A61K31/445 , C07D211/26 , C07D401/06
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公开(公告)号：EP2707372B1
公开(公告)日：2016-12-21
申请号：EP12782304.5
申请日：2012-05-11
IPC分类号： C07D487/10 , C07D413/12 , A61K31/407 , A61P35/00
CPC分类号： C07D487/10
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5.发明公开
公开(公告)号：EP2668180A2
公开(公告)日：2013-12-04
申请号：EP12739376.7
申请日：2012-01-24
发明人： WANG, Shaomeng , ZHOU, Haibin , CHEN, Jianfang , AGUILAR, Angelo , MEAGHER, Jennifer, Lynn , SUN, Duxin , YANG, Chao-Yie , LIU, Liu , BAI, Longchuan , MCEACHERM, Donna , STUCKEY, Jeanne , LI, Xiaoqin
IPC分类号： C07D403/10 , C07D403/14 , A61K31/496 , A61P35/00
CPC分类号： C07D239/28 , C07D207/34 , C07D231/12 , C07D233/28 , C07D233/56 , C07D261/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
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公开(公告)号：EP3774731A1
公开(公告)日：2021-02-17
申请号：EP19777864.0
申请日：2019-03-29
发明人： WANG, Shaomeng , XU, Shilin , AGUILAR, Angelo , HUANG, Liyue , STUCKEY, Jeanne , ZHANG, Meng
IPC分类号： C07D211/22 , C07D401/12 , C07D401/14
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公开(公告)号：EP3440066A1
公开(公告)日：2019-02-13
申请号：EP17718290.4
申请日：2017-04-06
发明人： WANG, Shaomeng , LI, Yangbing , YANG, Jiuling , AGUILAR, Angelo , ZHOU, Bing , HU, Jiantao , XU, Fuming , REJ, Rohan , HAN, Xin
IPC分类号： C07D401/04 , C07D487/10 , A61K31/4745 , A61P35/00
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公开(公告)号：EP3689886A1
公开(公告)日：2020-08-05
申请号：EP20163914.3
申请日：2014-01-15
发明人： WANG, Shaomeng , CHEN, Jianfang , MCEACHERN, Donna , BAI, Longchuan , LIU, Liu , SUN, Duxin , LI, Xiaoqin , AGUILAR, Angelo
IPC分类号： C07F9/6509 , A61K31/496 , A61P35/00 , A61K31/675 , A61K38/16
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
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公开(公告)号：EP2945940B1
公开(公告)日：2020-07-15
申请号：EP14741180.5
申请日：2014-01-15
发明人： WANG, Shaomeng , CHEN, Jianfang , MCEACHERN, Donna , BAI, Longchuan , LIU, Liu , SUN, Duxin , LI, Xiaoqin , AGUILAR, Angelo
IPC分类号： C07D401/14 , A61K31/496 , A61P35/00
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公开(公告)号：EP3452461A1
公开(公告)日：2019-03-13
申请号：EP17722968.9
申请日：2017-05-02
发明人： WANG, Shaomeng , AGUILAR, Angelo , ZHANG, Ke , XU, Shilin , XU, Tianfeng , BERNARD, Denzil , HUANG, Liyue
IPC分类号： C07D401/04 , C07D401/14 , C07D405/04 , C07D211/34 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61P35/00
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