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公开(公告)号：EP2707474B1
公开(公告)日：2019-07-10
申请号：EP12785188.9
申请日：2012-05-14
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公开(公告)号：EP2972405A1
公开(公告)日：2016-01-20
申请号：EP14768515.0
申请日：2014-03-13
CPC分类号： B01J19/0046 , B01J2219/00587 , B01J2219/00599 , B01J2219/00713 , B01J2219/00722 , B01J2219/00756 , B01L3/0265 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2300/0816 , B01L2300/0867 , B01L2300/123 , B01L2400/0655 , B01L2400/086 , G01N35/08
摘要： Methods and devices for the formation and/or merging of droplets in microfluidic systems are provided. In certain embodiments a microfluidic droplet merger component is provided that comprises a central channel comprising a plurality of elements disposed and spaced to create a plurality of lateral passages that drain a carrier fluid out of a fluid stream comprising droplets of a first fluid contained in the carrier fluid; and a deformable lateral membrane valve disposed to control the width of said center channel.
摘要翻译： 提供了用于在微流体系统中形成和/或合并液滴的方法和装置。 在某些实施例中，提供微流体微滴合并器部件，其包括中央通道，所述中央通道包括多个元件，所述中央通道包括多个元件，所述多个元件设置并间隔开以产生多个横向通道，所述横向通道从流体流中排出载体流体，所述流体流包含载体 流体; 以及一个可变形的横向膜片阀门，用于控制所述中心通道的宽度。
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3.发明公开HIGH-THROUGHPUT CARGO DELIVERY INTO LIVE CELLS USING PHOTOTHERMAL PLATFORMS 审中-公开具有高吞吐量在活细胞中，通过光热PLATFORMS货船
公开(公告)号：EP2971011A1
公开(公告)日：2016-01-20
申请号：EP14768087.0
申请日：2014-03-13
CPC分类号： C12N15/64 , C12M35/02 , C12N5/0602 , C12N13/00 , C12N15/87
摘要： Methods, devices, and systems are provided for the delivery of agents (e.g., nucleic acids, proteins, organic molecules, organelles, antibodies or other ligands, 5 etc.) into live cells and/or the extraction of the same from said cells. In various embodiments the photothermal platforms and systems incorporating such photothermal platforms are provided that permit efficient, high-throughput cargo delivery into live cells.
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公开(公告)号：EP3180418A1
公开(公告)日：2017-06-21
申请号：EP15831613.3
申请日：2015-08-14
发明人： YANG, Yajia , MAO, Yufei , CHIOU, Pei-Yu E. , CHUI, Chi On
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2400/0454 , B03C5/005 , B03C5/026 , B03C2201/26 , G01N15/10 , G01N2035/1046 , G02B21/32
摘要： A novel Self-Locking Optoelectronic Tweezers (SLOT) for single microparticle manipulation across a large area is provided. DEP forces generated from ring-shape lateral phototransistors are utilized for locking single microparticles or cells in the dark state. The locked microparticles or cells can be selectively released by optically deactivating these locking sites.
摘要翻译： 提供了一种新颖的自锁光电镊子（SLOT），用于在大面积上进行单个微粒操作。 利用由环形侧向光电晶体管产生的DEP力来锁定处于黑暗状态的单个微粒或单元。 锁定的微粒或细胞可通过光学去活这些锁定位点来选择性释放。
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公开(公告)号：EP2707474A2
公开(公告)日：2014-03-19
申请号：EP12785188.9
申请日：2012-05-14
摘要： This invention provides novel tools for surgery on single cells and substrates/devices for delivery of reagents to selected cells. In certain embodiments the substrates comprise a surface comprising one or more orifices, where nanoparticles and/or a thin film is deposited on a surface of said orifice or near said orifice, where the nanoparticles and/or a thin film are formed of materials that heat up when contacted with electromagnetic radiation. In certain embodiments the pores are in fluid communication with microchannels containing one or more reagents to be delivered into the cells.
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