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公开(公告)号：EP2852671B1
公开(公告)日：2018-08-22
申请号：EP13794196.9
申请日：2013-05-21
CPC分类号： C12N5/0696 , C07K14/4702 , C07K14/4705 , C12N9/127 , C12N15/86 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/1307 , C12N2770/36122 , C12N2770/36143 , C12N2840/206 , G01N33/56966
摘要： The disclosure provides methods and compositions useful for obtaining induced stem cells, methods of making and use thereof.
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公开(公告)号：EP4225326A1
公开(公告)日：2023-08-16
申请号：EP21880918.4
申请日：2021-10-12
IPC分类号： A61K31/713 , A61K47/54 , C12N15/11
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公开(公告)号：EP2046964B1
公开(公告)日：2018-07-04
申请号：EP07796847.7
申请日：2007-07-11
CPC分类号： C12N15/87 , A61K48/00 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/3513 , C12N2320/32 , C12N2330/30
摘要： This disclosure relates to nucleic acid constructs modified to have a reduced net anionic charge. In some aspects the constructs comprise phosphodiester and/or phosphothioate protecting groups. The disclosure also provide methods of making and using such constructs.
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4.发明公开
公开(公告)号：EP2046964A2
公开(公告)日：2009-04-15
申请号：EP07796847.7
申请日：2007-07-11
CPC分类号： C12N15/87 , A61K48/00 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/3513 , C12N2320/32 , C12N2330/30
摘要： This disclosure relates to nucleic acid constructs modified to have a reduced net anionic charge. In some aspects the constructs comprise phosphodiester and/or phosphothioate protecting groups. The disclosure also provide methods of making and using such constructs.
摘要翻译： 本公开涉及修饰成具有降低的净阴离子电荷的核酸构建体。 在一些方面，构建体包含磷酸二酯和/或硫代磷酸酯保护基团。 本公开还提供了制造和使用这种构建体的方法。
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5.发明公开TRANSDUCIBLE DELIVERY OF SIRNA BY DSRNA BINDING DOMAIN FUSIONS TO PTD/CPPS 审中-公开通过DSRNA与PTD / CPPS结合区域融合，可交换地传递SIRNA
公开(公告)号：EP1984399A2
公开(公告)日：2008-10-29
申请号：EP07750474.4
申请日：2007-02-09
CPC分类号： C12N15/111 , C07K2319/10 , C07K2319/85 , C12N2310/14 , C12N2320/32
摘要： The disclosure provides fusion polypeptides and constructs useful in delivering anionically charged nucleic acid molecules including diagnostics and therapeutics to a cell or subject. The fusion constructs include a protein transduction domain and a nucleic acid binding domain, or a protein transduction domain and a nucleic acid that is coated with one or more nucleic acid binding domains sufficient to neutralize an anionic charge on the nucleic acid. Also provided are methods of treating disease and disorders such as cell proliferative disorders.
摘要翻译： 本公开提供了用于将包括诊断剂和治疗剂的带阴离子电荷的核酸分子递送至细胞或受试者的融合多肽和构建体。 融合构建体包括蛋白质转导结构域和核酸结合结构域，或蛋白质转导结构域和用足以中和核酸上的阴离子电荷的一个或多个核酸结合结构域包被的核酸。 还提供了治疗疾病和病症例如细胞增殖性病症的方法。
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公开(公告)号：EP2438079A2
公开(公告)日：2012-04-11
申请号：EP10783926.8
申请日：2010-06-01
发明人： DOWDY, Steven, F. , MEADE, Bryan , GOGOI, Khirud
IPC分类号： C07H21/02 , C12N15/113 , A61K31/7105 , A61K48/00
CPC分类号： A61K48/0091 , C07H19/073 , C07H19/16 , C07H19/173 , C07H21/04 , C12N15/111 , C12N2310/311 , C12N2320/50 , Y02P20/55 , C12N2310/3527
摘要： This disclosure relates to nucleic acid constructs modified to have a reduced net anionic charge. The constructs comprise phosphotriester and/or phosphothioate protecting groups. The disclosure also provides methods of making and using such constructs.
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7.发明公开GENERATION OF HUMAN IPS CELLS BY A SYNTHETIC SELF- REPLICATIVE RNA 审中-公开人类iPS细胞已经合成RNA SELBSTREPLIKATIVER的方式生产
公开(公告)号：EP2852671A2
公开(公告)日：2015-04-01
申请号：EP13794196.9
申请日：2013-05-21
CPC分类号： C12N5/0696 , C07K14/4702 , C07K14/4705 , C12N9/127 , C12N15/86 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/1307 , C12N2770/36122 , C12N2770/36143 , C12N2840/206 , G01N33/56966
摘要： The disclosure provides methods and compositions useful for obtaining induced stem cells, methods of making and use thereof.
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