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1.发明授权DISUBSTITUTED BETA-LACTONES AS INHIBITORS OF N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) 有权分析化学结合抑制剂N-乙酰氨基酚氨基酸（NAAA）
公开(公告)号：EP2782567B1
公开(公告)日：2017-03-22
申请号：EP12851203.5
申请日：2012-11-21
申请人： The Regents of the University of California , Fondazione Istituto Italiano Di Tecnologia , Universita Degli Studi Di Urbino , Università degli Studi di Parma
发明人： PIOMELLI, Daniele , BANDIERA, Tiziano , MOR, Marco , TARZIA, Giorgio , BERTOZZI, Fabio , PONZANO, Stefano
IPC分类号： C07D405/12 , C07D407/12 , C07D409/12 , C07D305/12 , A61K31/337 , A61K31/38 , A61P29/00 , A61P17/00
CPC分类号： A61K31/365 , A61K9/0014 , A61K31/38 , C07D305/12 , C07D405/12 , C07D407/12 , C07D409/12
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2.发明公开META-SUBSTITUTED BIPHENYL PERIPHERALLY RESTRICTED FAAH INHIBITORS 审中-公开外设EINGESCHRÄNKTEFAAH-HEMMER AUS META-SUBSTITUIERTEM BIPHENYL
公开(公告)号：EP2744778A2
公开(公告)日：2014-06-25
申请号：EP12826376.1
申请日：2012-08-17
申请人： The Regents of the University of California , Fondazione Istituto Italiano Di Tecnologia , Università Degli Studi Di Urbino "Carlo Bo" , Università degli Studi di Parma
IPC分类号： C07C233/06 , C07C233/23 , C07D309/14 , A61K31/165 , A61P29/00
CPC分类号： C07C271/56 , C07C269/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D309/14
摘要： The present invention provides methods of making and using peripherally restricted inhibitors of fatty acid amide hydrolase (FAAH). The present invention provides compounds and compositions that suppress FAAH activity and increases anandamide levels outside the central nervous system (CNS). The present invention also sets forth methods for inhibiting FAAH as well as methods for treating conditions such as, but not limited to, pain, inflammation, immune disorders, dermatitis, mucositis, the over reactivity of peripheral sensory neurons, neurodermatitis, and an overactive bladder. Accordingly, the invention also provides compounds, methods, and pharmaceutical compositions for treating conditions in which the selective inhibition of peripheral FAAH (as opposed to CNS FAAH) would be of benefit.
摘要翻译： 本发明提供制备和使用外周限制性脂肪酸酰胺水解酶抑制剂（FAAH）的方法。 本发明提供抑制FAAH活性并增加中枢神经系统（CNS）外的氨基酰胺水平的化合物和组合物。 本发明还提出了用于抑制FAAH的方法以及治疗诸如但不限于疼痛，炎症，免疫病症，皮炎，粘膜炎，周围感觉神经元，神经性皮炎和膀胱过度活动症的过度反应的病症的方法 。 因此，本发明还提供了用于治疗其中选择性抑制外周FAAH（与CNS FAAH相反））有益的化合物，方法和药物组合物。
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3.发明公开DISUBSTITUTED BETA-LACTONES AS INHIBITORS OF N-ACYLETHANOLAMINE ACID AMIDASE (NAAA) 有权BETA二取代内酯作为N-ACYLETHANOLAMINSÄURE酰胺酶的抑制剂（NAAA）
公开(公告)号：EP2782567A1
公开(公告)日：2014-10-01
申请号：EP12851203.5
申请日：2012-11-21
申请人： The Regents of the University of California , IIT - Istituto Italiano di Tecnologia , Universita Degli Studi Di Urbino , Università degli Studi di Parma
发明人： PIOMELLI, Daniele , BANDIERA, Tiziano , MOR, Marco , TARZIA, Giorgio , BERTOZZI, Fabio , PONZANO, Stefano
IPC分类号： A61K31/337 , A61K31/38 , A61P29/00 , A61P17/00
CPC分类号： A61K31/365 , A61K9/0014 , A61K31/38 , C07D305/12 , C07D405/12 , C07D407/12 , C07D409/12
摘要： The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.
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4.发明授权COMPOSITIONS AND METHODS OF INHIBITING N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE 有权组合物和用于抑制的N-酰基乙醇胺水解SÄUREAMIDASE方法
公开(公告)号：EP2200564B1
公开(公告)日：2016-05-04
申请号：EP08838096.9
申请日：2008-10-10
申请人： The Regents of the University of California , Università degli Studi di Parma , Universita degli Studi di Urbino "Carlo Bo"
CPC分类号： A61K31/337 , A61K31/165 , A61K31/195 , A61K31/365 , C07D305/10
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公开(公告)号：EP2744778B1
公开(公告)日：2019-01-16
申请号：EP12826376.1
申请日：2012-08-17
申请人： The Regents of the University of California , Fondazione Istituto Italiano di Tecnologia , Università Degli Studi Di Urbino "Carlo Bo" , Università degli Studi di Parma
IPC分类号： C07C269/02 , C07C271/56 , C07D309/14
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6.发明公开SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS 有权AS苯并恶唑酮的酸性神经酰胺酶抑制剂取代衍生物及其作为药物
公开(公告)号：EP3143009A1
公开(公告)日：2017-03-22
申请号：EP15727567.8
申请日：2015-05-11
申请人： Fondazione Istituto Italiano di Tecnologia , The Regents of the University of California , Università degli Studi di Parma
发明人： PIOMELLI, Daniele , PIZZIRANI, Daniela , BACH, Anders , SCARPELLI, Rita , MELZIG, Laurin , MOR, Marco
IPC分类号： C07D263/58 , A61K31/423 , A61P35/00
摘要： The present invention relates to substituted benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides substituted benzoxazolone derivatives for use in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.
摘要翻译： 本发明涉及substituiertem benzoxazolones衍生物作为酸性神经酰胺酶抑制剂，含合成抑制剂和酸抑制神经酰胺的方法在神经酰胺水平的哪个调制病症的治疗的药物组合物是临床相关的。 因此本发明提供substituiertem benzoxazolones衍生物用于癌症，炎症，疼痛，炎性疼痛或肺疾病的治疗用途。
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公开(公告)号：EP2875006A1
公开(公告)日：2015-05-27
申请号：EP13739362.5
申请日：2013-05-27
申请人： Fondazione Istituto Italiano Di Tecnologia , The Regents of the University of California , Università degli Studi di Parma
发明人： PIOMELLI, Daniele , REALINI, Natalia , MOR, Marco , PAGLIUCA, Chiara , PIZZIRANI, Daniela , SCARPELLI, Rita , BANDIERA, Tiziano
IPC分类号： C07D239/54 , C07D239/557 , C07D239/553 , C07D239/545
CPC分类号： C07D239/54 , A61K31/513 , A61K31/5377 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D239/545 , C07D239/553 , C07D239/557 , C07D239/60 , C07D401/04 , C07D403/04
摘要： The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant.
摘要翻译： 本发明在第一方面涉及本文定义的式I化合物，其药学上可接受的盐和含有这些化合物的药物组合物。 本发明还涉及用作酸性神经酰胺酶抑制剂的式I化合物，以及用于治疗其中神经酰胺水平的调节在临床上相关的癌症和其它疾病。
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公开(公告)号：EP2875006B1
公开(公告)日：2018-12-26
申请号：EP13739362.5
申请日：2013-05-27
申请人： Fondazione Istituto Italiano di Tecnologia , The Regents of the University of California , Università degli Studi di Parma
发明人： PIOMELLI, Daniele , REALINI, Natalia , MOR, Marco , PAGLIUCA, Chiara , PIZZIRANI, Daniela , SCARPELLI, Rita , BANDIERA, Tiziano
IPC分类号： C07D239/54 , C07D239/557 , C07D239/553 , C07D239/545 , A61K31/513 , A61K31/5377 , A61P35/00
CPC分类号： C07D239/54 , A61K31/513 , A61K31/5377 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D239/545 , C07D239/553 , C07D239/557 , C07D239/60 , C07D401/04 , C07D403/04
摘要： The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant.
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9.发明授权Novel elatonin ligands having antidepressant activity as well as sleep inducing properties 有权新Elatoninliganden具有抗抑郁活性和睡眠功能
公开(公告)号：EP1973868B1
公开(公告)日：2015-09-09
申请号：EP07701686.3
申请日：2007-01-12
申请人： McGill University , Università degli Studi di Parma , UNIVERSITA' DEGLI STUDI DI MILANO , Universita Degli Studi Di Urbino
发明人： GOBBI, Gabriella , MOR, Marco , RIVARA, Silvia , FRASCHINI, Franco , TARZIA, Giorgio , BEDINI, Annalida , SPADONI, Gilberto , LUCINI, Valeria
IPC分类号： C07C237/04 , C07C233/36 , A61P25/00
CPC分类号： C07C233/43 , C07C233/36
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公开(公告)号：EP1558591B1
公开(公告)日：2014-05-07
申请号：EP03773201.3
申请日：2003-10-07
申请人： The Regents of The University of California , Universita Degli Studi di Urbino , Universita Degli Studi di Parma
IPC分类号： C07D271/00 , A61K31/21 , A61P25/22 , C07C271/56 , C07C275/54 , C07C311/29
CPC分类号： C07C311/29 , C07C271/56 , C07C275/54 , C07C2601/14 , C07D209/08 , C07D211/06 , C07D215/06 , C07D307/79 , C07D487/04
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