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1.发明公开
公开(公告)号：EP2323680A2
公开(公告)日：2011-05-25
申请号：EP09800676.0
申请日：2009-07-23
CPC分类号： A61K35/26 , A61K38/08 , A61K38/10 , C07K14/47 , G01N33/56988 , G01N2333/5759 , Y02A50/401 , Y02A50/57
摘要： The present invention describes compositions of thymus derived peptides and uses therefore in diagnostic methods and for the treatment of diseases associated with reduced T helper cell counts, diseases such as infection, e.g., HIV infection and other viral infections, parasitic, and bacterial infection, AIDS, ARC, multiple sclerosis, chronic fatigue syndrome, rheumatoid arthritis, Alzheimer's disease, asthma, allergy, dermatitis, type 1 diabetes mellitus, colitis, inflammatory bowel disease/irritable bowel syndrome, Crohn's disease, Psoriasis, Chronic obstructive pulmonary disease, Systemic lupus erythematosus, transplant rejection and cancer.
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公开(公告)号：EP2323679A2
公开(公告)日：2011-05-25
申请号：EP09800699.2
申请日：2009-07-23
CPC分类号： A61K45/06 , A61K38/08 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/465 , Y02A50/471 , Y02A50/475 , Y02A50/57 , A61K2300/00
摘要： The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, allergic disease transplant and cell graft rejection, cancer, bacterial infection, HIV infection, and AIDS.
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公开(公告)号：EP2323681A2
公开(公告)日：2011-05-25
申请号：EP09800696.8
申请日：2009-07-23
CPC分类号： A61K45/06 , A61K31/00 , A61K33/08 , A61K33/42 , A61K35/26 , A61K38/08 , A61K38/10 , C07K14/005 , C12N2740/16222 , A61K2300/00
摘要： The invention relates to topical formulations of CLIP inhibitors as well as methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with viral infection, such as HIV infection, and AIDS.
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公开(公告)号：EP2117558A2
公开(公告)日：2009-11-18
申请号：EP08724877.9
申请日：2008-01-28
IPC分类号： A61K31/70 , A61K38/00 , A61K39/00 , A61K39/395 , G01N33/48
CPC分类号： A61K45/06 , A61K31/03 , A61K31/40 , A61K31/4706 , A61K31/7088 , A61K38/10 , A61K39/395 , Y02A50/401 , A61K2300/00
摘要： The invention relates to methods for modulating the immune function through targeting of CLIP molecules as well as gamma delta T cells. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, transplant and cell graft rejection, cancer, bacterial infection, HIV infection, and AIDS, as well as novel methods of diagnosis and of introducing a treatment regimen into a subject.
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公开(公告)号：EP2313095A2
公开(公告)日：2011-04-27
申请号：EP09798298.7
申请日：2009-07-14
IPC分类号： A61K31/4409 , A61K39/395 , A61K31/7004 , A61P35/00
CPC分类号： C07K16/22 , A61K31/4409 , A61K31/4706 , A61K31/7004 , A61K39/395 , A61K45/06 , A61K2039/505 , A61K2300/00
摘要： Methods and products for treating proliferative diseases, and wounds, using as a pharmacon an autophagy inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In some embodiments, the invention combines a 4-aminoquinoline, exemplified by chloroquine, with a glycolytic inhibitor, exemplified by 2-deoxy-D-glucose and anti-VEGF antibodies. The systems and methods of the invention may be used to treat drug-resistant or multi-drug resistant cancers.
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6.发明公开COMPETITIVE INHIBITORS OF INVARIANT CHAIN EXPRESSION AND/OR ECTOPIC CLIP BINDING 审中-公开表达式的常量链和/或异位CLIP领带的竞争性抑制剂
公开(公告)号：EP2215108A2
公开(公告)日：2010-08-11
申请号：EP08841310.9
申请日：2008-10-23
CPC分类号： A61K38/08 , A61K38/00 , A61K39/0011 , C07K7/06 , C40B30/02 , G06F19/16 , G06F19/18 , Y02A50/401 , Y02A50/409 , Y02A50/411
摘要： The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, cancer, Alzheimer's disease, allergic disease, transplant and cell graft rejection, HIV infection and other viral, bacterial, and parasitic infection, and AIDS. Methods are also provided for preparing a peptide having the property of being able to displace CLIP by feeding one or more peptide sequences into software that predicts MHC Class II binding regions in an antigen sequence and related products.
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