公开(公告)号：EP1919494A2

公开(公告)日：2008-05-14

申请号：EP06849801.3

申请日：2006-07-21

申请人： The Regents of the University of Colorado, A Body Corporate ,  University of Alberta

发明人： HODGES, Robert S. ,  IRVIN, Randall T. ,  GILTNER, Carmen ,  VAN SCHAIK, Erin

IPC分类号： A61K38/16

CPC分类号： A61K38/164 ,  A61L12/14 ,  A61L27/227 ,  A61L27/54 ,  A61L29/048 ,  A61L29/16

摘要： The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.

公开(公告)号：EP2667894A1

公开(公告)日：2013-12-04

申请号：EP12739836.0

申请日：2012-01-26

申请人： The Regents of the University of Colorado, a body corporate

发明人： HODGES, Robert S. ,  HOLMES, Kathryn V. ,  YAN, Zhe ,  HARTSOCK, Wendy Jeanne ,  QIAN, Zhaohui ,  HIRSCH, Brooke Elizabeth Bishop

IPC分类号： A61K39/385 ,  C07K1/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K47/643 ,  A61K2039/6081 ,  A61K2039/64 ,  C12N2760/16134

摘要： Templated conjugates created from naturally-occurring protein sequences found in pathogens, such as viruses, are disclosed. The sequences are "templated" into a consensus coiled-coil sequence in a platform in order to form a two- stranded antigen suitable for immunization of a subject.