公开(公告)号：EP2782928A1

公开(公告)日：2014-10-01

申请号：EP12851407.2

申请日：2012-11-21

申请人： The Royal Institution for the Advancement of Learning / McGill University ,  German Cancer Research Center (DKFZ) ,  Universitätsklinikum Heidelberg

发明人： JABADO, Nada ,  PFISTER, Stefan M. ,  PLASS, Christoph ,  KORSHUNOV, Andrey ,  WITT, Hendrik ,  STURM, Dominik ,  JONES, David ,  LICHTER, Peter ,  PFAFF, Elke

IPC分类号： C07K14/47 ,  A61K38/17 ,  A61P35/00 ,  C07K16/18 ,  C12N15/12 ,  C12Q1/00 ,  G01N33/574 ,  G01N33/68

CPC分类号： G01N33/57496 ,  A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/34 ,  C12Q1/6886 ,  G01N33/57407 ,  G01N33/6875 ,  G01N2500/00 ,  G01N2800/50 ,  G01N2800/56

摘要： The present application shows the relationship between variations in the amino acid sequence of histone proteins, more specifically the H3.3 protein, and proliferation-associated disorders. Herewith provided are predictive methods, commercial packages, therapeutic methods and screening methods based on this relationship.

公开(公告)号：EP2782928B1

公开(公告)日：2017-01-04

申请号：EP12851407.2

申请日：2012-11-21

申请人： The Royal Institution for the Advancement of Learning / McGill University ,  German Cancer Research Center (DKFZ) ,  Universitätsklinikum Heidelberg

发明人： JABADO, Nada ,  PFISTER, Stefan M. ,  PLASS, Christoph ,  KORSHUNOV, Andrey ,  WITT, Hendrik ,  STURM, Dominik ,  JONES, David ,  LICHTER, Peter ,  PFAFF, Elke

IPC分类号： C07K14/47 ,  C07K16/18 ,  G01N33/574 ,  G01N33/68 ,  C12Q1/68

CPC分类号： G01N33/57496 ,  A61K38/00 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/34 ,  C12Q1/6886 ,  G01N33/57407 ,  G01N33/6875 ,  G01N2500/00 ,  G01N2800/50 ,  G01N2800/56