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1.发明授权COMPOSITIONS COMPRISING LARGE AND SMALL BINDING FRAGMENTS OF ANTIBODIES AGAINST THE SAME TOXIN 有权组合物中，大国和小对同一毒素展望古董BODY FRAGMENTS含
公开(公告)号：EP1629009B1
公开(公告)日：2012-03-14
申请号：EP04735923.7
申请日：2004-06-03
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/23 , C07K2317/31 , C07K2317/54 , C07K2317/55
摘要： A pharmaceutical composition comprising (i) a first specific binding agent selected from an antibody or a large binding fragment of an antibody which specifically binds a target toxin, and (ii) a second specific binding agent which comprises a small binding fragment of an antibody which binds said toxin. The compositions are used in the treatment of toxin poisoning, for example following exposure to toxins such as Botulinum toxins.
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2.发明授权COMPOSITIONS COMPRISING LARGE AND SMALL BINDING FRAGMENTS OF ANTIBODIES AGAINST THE SAME TOXIN 有权包含抗体对相同毒素的大和小结合片段的组合物
公开(公告)号：EP1629009B8
公开(公告)日：2012-04-18
申请号：EP04735923.7
申请日：2004-06-03
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/23 , C07K2317/31 , C07K2317/54 , C07K2317/55
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3.发明公开METHOD FOR PRODUCING TOXOIDS USING ALPHA - DICARBONYL COMPOUNDS& xA; 审中-公开用于生产类毒素使用alpha二羰CONNECTIONS
公开(公告)号：EP2593132A2
公开(公告)日：2013-05-22
申请号：EP11746274.7
申请日：2011-07-18
IPC分类号： A61K39/00
CPC分类号： C07K14/415 , A61K38/00 , A61K39/39 , A61K2039/55544 , C07K14/21 , C07K14/235 , C07K14/25 , C07K14/28 , C07K14/31 , C07K14/33 , C07K14/46 , C07K16/1282 , C07K16/16 , C12N9/2497 , C12N9/52 , C12Y302/02022
摘要： The present invention relates to the use of toxoids prepared using a-dicarbonyl toxoiding reagents such as glyoxal, butanedione and phenylglyoxal. The toxoids may be prepared with low concentrations of toxoiding reagent and in short periods of time, often in as few as 24 hours, making the toxoiding reagents particularly advantageous when compared with traditional formaldehyde toxoiding. Toxoids prepared using dicarbonyl reagents such as phenylglyoxal are described and claimed as are pharmaceutical and vaccine compositions comprising the toxoids, methods of treatment using such compositions and antibodies generated by immunisation with the toxoid and methods of treatment using the antibodies so prepared or fragments of such antibodies.
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公开(公告)号：EP0643602A1
公开(公告)日：1995-03-22
申请号：EP93913297.0
申请日：1993-06-04
发明人： WHITFIELD, David , BATTENSBY, James , CLARK, Adrian James , HOLMES, Susan Elizabeth , GRIFFITHS, David Mark
CPC分类号： B32B5/26 , A62D5/00 , B32B5/022 , B32B5/024 , B32B2262/106 , B32B2307/714 , B32B2307/724 , B32B2307/73 , B32B2310/04 , B32B2571/00
摘要： The present invention relates to novel composite fabrics having resistance to penetration by chemical agents, particularly organic chemical agents of a gaseous and/or liquid nature such as may be encountered in the chemical industry or in military situations where chemical warfare agents have been deployed. The fabrics of the invention have application in the manufacture of protective clothing for use in chemically contaminated environments or in the manufacture of other items for protecting humans and their equipment, eg. casualty evacuation bags or respirator bags. The fabrics comprise two shell layers provided above one or more anti-gas carbon containing fabric layers, at least one of the shell layers being oil-repellent with the both layers most preferably being of oil-repellent nature or the other being an organic liquid wicking layer.
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5.发明公开COMPOSITIONS COMPRISING LARGE AND SMALL BINDING FRAGMENTS OF ANTIBODIES AGAINST THE SAME TOXIN 有权组合物中，大国和小对同一毒素展望古董BODY FRAGMENTS含
公开(公告)号：EP1629009A1
公开(公告)日：2006-03-01
申请号：EP04735923.7
申请日：2004-06-03
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/23 , C07K2317/31 , C07K2317/54 , C07K2317/55
摘要： A pharmaceutical composition comprising (i) a first specific binding agent selected from an antibody or a large binding fragment of an antibody which specifically binds a target toxin, and (ii) a second specific binding agent which comprises a small binding fragment of an antibody which binds said toxin. The compositions are used in the treatment of toxin poisoning, for example following exposure to toxins such as Botulinum toxins.
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