公开(公告)号：EP4349410A3

公开(公告)日：2024-06-05

申请号：EP23171081.5

申请日：2017-01-05

申请人： The Trustees Of Columbia University In The City Of New York

发明人： IAVARONE, Antonio ,  LASORELLA, Anna

IPC分类号： A61K38/45 ,  A61K38/44 ,  A61K38/19 ,  A61K48/00 ,  C12N15/63 ,  C12N5/10 ,  C12N15/12 ,  C12N9/12 ,  A61P35/00 ,  A61K45/06

CPC分类号： A61K38/44 ,  C12Y114/11002 ,  C12Y207/12001 ,  C12N2510/0020130101 ,  A61K38/45 ,  A61P35/00 ,  A61K45/06

摘要： The present disclosure provides a composition for use in the therapeutic treatment of a cancer or a tumor in a patient, said composition comprising an isolated Dual-Specificity Tyrosine-Phosphorylation-Regulated Protein Kinase 1 (DYRK1) protein and isolated prolyl hydroxylase (PHD) protein, wherein the composition increases degradation of Hypoxia-Inducible Factor-α (HIFα) in cancer cells or tumor cells in the patient and/or decreases half-life of HIFα in the cancer cells or the tumor cells in the patient.

公开(公告)号：EP4349410A2

公开(公告)日：2024-04-10

申请号：EP23171081.5

申请日：2017-01-05

申请人： The Trustees Of Columbia University In The City Of New York

发明人： IAVARONE, Antonio ,  LASORELLA, Anna

IPC分类号： A61P35/00

摘要： The present disclosure provides a composition for use in the therapeutic treatment of a cancer or a tumor in a patient, said composition comprising an isolated Dual-Specificity Tyrosine-Phosphorylation-Regulated Protein Kinase 1 (DYRK1) protein and isolated prolyl hydroxylase (PHD) protein, wherein the composition increases degradation of Hypoxia-Inducible Factor-α (HIFα) in cancer cells or tumor cells in the patient and/or decreases half-life of HIFα in the cancer cells or the tumor cells in the patient.

公开(公告)号：EP4267768A1

公开(公告)日：2023-11-01

申请号：EP21912200.9

申请日：2021-12-22

申请人： The Trustees Of Columbia University In The City Of New York

发明人： IAVARONE, Antonio ,  LASORELLA, Anna

IPC分类号： C12Q1/6886 ,  G01N33/574 ,  A61P35/00

公开(公告)号：EP3778644A2

公开(公告)日：2021-02-17

申请号：EP20197862.4

申请日：2015-12-23

申请人： The Trustees of Columbia University in the City of New York

发明人： LASORELLA, Anna ,  IAVARONE, Antonio

IPC分类号： C07K16/28 ,  G01N33/574 ,  C12Q1/6886 ,  C07K14/71

摘要： The invention discloses FGFR-TACC oncogenic fusion proteins. The invention provides methods for treating and diagnosing gene-fusion based cancers.

公开(公告)号：EP4176055A1

公开(公告)日：2023-05-10

申请号：EP21832441.6

申请日：2021-06-23

申请人： The Trustees Of Columbia University In The City Of New York

发明人： IAVARONE, Antonio ,  LASORELLA, Anna

IPC分类号： C12N9/12 ,  C12Q1/25 ,  C12Q1/26

公开(公告)号：EP3778644A3

公开(公告)日：2021-06-02

申请号：EP20197862.4

申请日：2015-12-23

申请人： The Trustees of Columbia University in the City of New York

发明人： LASORELLA, Anna ,  IAVARONE, Antonio

IPC分类号： C07K16/28 ,  G01N33/574 ,  C12Q1/6886 ,  C07K14/71 ,  A61K31/496 ,  A61K31/519

摘要： The invention discloses FGFR-TACC oncogenic fusion proteins. The invention provides methods for treating and diagnosing gene-fusion based cancers.

公开(公告)号：EP2968551A1

公开(公告)日：2016-01-20

申请号：EP14769771.8

申请日：2014-03-13

申请人： The Trustees of Columbia University in the City of New York

发明人： IAVARONE, Antonio ,  LASORELLA, Anna ,  RABADAN, Raul

IPC分类号： A61K39/395

CPC分类号： C12N9/12 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K38/179 ,  C07K14/435 ,  C07K14/47 ,  C07K14/4738 ,  C07K14/71 ,  C07K16/40 ,  C07K2317/76 ,  C07K2319/00 ,  C12N9/16 ,  C12Q1/6886 ,  C12Y207/10001 ,  C12Y301/03003 ,  G01N33/573 ,  G01N33/57484 ,  G01N2333/71 ,  A61K2300/00

摘要： The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.

公开(公告)号：EP4276200A3

公开(公告)日：2024-02-14

申请号：EP22194193.3

申请日：2013-07-24

申请人： The Trustees of Columbia University in the City of New York

发明人： IAVARONE, Antonio ,  LASORELLA, Anna ,  RABANDAN, Raul

IPC分类号： C07K14/71 ,  C12N9/12 ,  C12Q1/68 ,  C07K14/50 ,  A61P35/00 ,  A61P43/00 ,  C12Q1/6886

摘要： The invention discloses oncogenic fusion proteins. The inventions provides methods for treating gene-fusion based cancers.

公开(公告)号：EP3925979A3

公开(公告)日：2022-03-23

申请号：EP21173909.9

申请日：2015-12-23

申请人： The Trustees of Columbia University in the City of New York

发明人： LASORELLA, Anna ,  IAVARONE, Antonio

IPC分类号： C07K16/28 ,  G01N33/574 ,  C12Q1/6886 ,  C07K14/71 ,  A61K31/496 ,  A61K31/519

摘要： The invention discloses oncogenic fusion proteins. The invention provides methods for treating and diagnosing gene-fusion based cancers.

公开(公告)号：EP3400003A1

公开(公告)日：2018-11-14

申请号：EP17736345.4

申请日：2017-01-05

申请人： The Trustees of Columbia University in the City of New York

发明人： IAVARONE, Antonio ,  LASORELLA, Anna

IPC分类号： A61K38/45 ,  A61K38/44 ,  A61K38/19 ,  A61K48/00 ,  C12N15/63 ,  C12N5/10 ,  C12N15/12 ,  C12N9/12

CPC分类号： A61K38/45 ,  A61K38/44 ,  A61P35/00 ,  C12N2510/00 ,  C12Y114/11002 ,  C12Y207/12001

摘要： The present disclosure provides, in one embodiment, a method of treating or preventing an ID2 protein-related disease in a patient at risk of developing or having such a disease by administering to the patient a composition in an amount and for a time sufficient to increase degradation of HIFα in a cell affected by the ID2 protein-related disease in the patent and/or to decrease half-life of HIFα in the cell affected by the ID2 protein-related disease in the patient, as compared to an untreated cell affected by the ID2 protein-related disease.