公开(公告)号：EP2864352A1

公开(公告)日：2015-04-29

申请号：EP13806673.3

申请日：2013-06-21

申请人： The Trustees Of Darthmouth College ,  King's College London

发明人： NOELLE, Randolph, J. ,  CEERAZ, Sabrina ,  LEMERCIER, Isabelle ,  NOWAK, Elizabeth ,  LINES, Janet, Louise

IPC分类号： C07K14/47 ,  C07K19/00 ,  A61K39/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/18 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0325 ,  A01K2267/0368 ,  A01K2267/0387 ,  A61K38/00 ,  A61K39/39 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/70503 ,  C07K14/70532 ,  C07K16/2827 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/735 ,  C12N15/1138 ,  C12N2310/14 ,  A61K31/00

摘要： The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease and type 1 or type 2 diabetes.

公开(公告)号：EP3094346B1

公开(公告)日：2019-12-11

申请号：EP15737353.1

申请日：2015-01-23

申请人： The Trustees Of Dartmouth College ,  King's College London ,  Spaller, Mark

发明人： NOELLE, Randolph, J. ,  CEERAZ, Sabrina ,  LEMERCIER, Isabelle ,  NOWAK, Elizabeth ,  LINES, Janet ,  WANG, Li ,  SPALLER, Mark

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K38/00 ,  A61K38/10 ,  G01N33/566 ,  C07K16/28 ,  C07K7/08

公开(公告)号：EP2864352B1

公开(公告)日：2018-08-08

申请号：EP13806673.3

申请日：2013-06-21

申请人： The Trustees Of Dartmouth College ,  King's College London

发明人： NOELLE, Randolph, J. ,  CEERAZ, Sabrina ,  LEMERCIER, Isabelle ,  NOWAK, Elizabeth ,  LINES, Janet, Louise

IPC分类号： C07K14/47 ,  C07K16/28 ,  C07K19/00 ,  A61K39/00 ,  A61P35/00 ,  A61P37/00 ,  A01K67/027 ,  A61K38/17 ,  C07K14/705 ,  C12N15/113

CPC分类号： C07K16/18 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0325 ,  A01K2267/0368 ,  A01K2267/0387 ,  A61K38/00 ,  A61K39/39 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/70503 ,  C07K14/70532 ,  C07K16/2827 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/735 ,  C12N15/1138 ,  C12N2310/14 ,  A61K31/00

摘要： The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease and type 1 or type 2 diabetes.

公开(公告)号：EP3421486A1

公开(公告)日：2019-01-02

申请号：EP18173447.6

申请日：2013-06-21

申请人： The Trustees Of Dartmouth College ,  King's College London

发明人： NOELLE, Randolph J. ,  CEERAZ, Sabrina ,  LEMERCIER, Isabelle ,  NOWAK, Elizabeth ,  LINES, Janet Louise

IPC分类号： C07K14/47 ,  C07K16/28 ,  C07K19/00 ,  A61K39/00 ,  A61P35/00 ,  A61P37/00 ,  A01K67/027 ,  A61K38/17 ,  C07K14/705 ,  C12N15/113

摘要： The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V- domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease and type 1 or type 2 diabetes.

公开(公告)号：EP3094346A2

公开(公告)日：2016-11-23

申请号：EP15737353.1

申请日：2015-01-23

申请人： The Trustees Of Dartmouth College ,  King's College London ,  Spaller, Mark

发明人： NOELLE, Randolph, J. ,  CEERAZ, Sabrina ,  LEMERCIER, Isabelle ,  NOWAK, Elizabeth ,  LINES, Janet ,  WANG, Li ,  SPALLER, Mark

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K38/00 ,  A61K38/10

摘要： The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

摘要翻译： 本发明涉及抑制VISTA活性的肽，多聚体，缀合物，类似物，衍生物或模拟物。 本发明进一步考虑了VISTA拮抗剂肽，多聚体，缀合物，衍生物或其模拟物的治疗用途，包括治疗或预防癌症，细菌感染，病毒感染，寄生虫感染和真菌感染以及拮抗剂的研究用途。