公开(公告)号：EP3094346A2

公开(公告)日：2016-11-23

申请号：EP15737353.1

申请日：2015-01-23

申请人： The Trustees Of Dartmouth College ,  King's College London ,  Spaller, Mark

发明人： NOELLE, Randolph, J. ,  CEERAZ, Sabrina ,  LEMERCIER, Isabelle ,  NOWAK, Elizabeth ,  LINES, Janet ,  WANG, Li ,  SPALLER, Mark

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K38/00 ,  A61K38/10

摘要： The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.

摘要翻译： 本发明涉及抑制VISTA活性的肽，多聚体，缀合物，类似物，衍生物或模拟物。 本发明进一步考虑了VISTA拮抗剂肽，多聚体，缀合物，衍生物或其模拟物的治疗用途，包括治疗或预防癌症，细菌感染，病毒感染，寄生虫感染和真菌感染以及拮抗剂的研究用途。

公开(公告)号：EP2892558B1

公开(公告)日：2019-04-10

申请号：EP13834707.5

申请日：2013-09-09

申请人： The Trustees Of Dartmouth College ,  King's College London

发明人： NOELLE, Randolph, J.

IPC分类号： A61K39/395 ,  A61K48/00 ,  A61P35/00

公开(公告)号：EP3094346B1

公开(公告)日：2019-12-11

申请号：EP15737353.1

申请日：2015-01-23

申请人： The Trustees Of Dartmouth College ,  King's College London ,  Spaller, Mark

发明人： NOELLE, Randolph, J. ,  CEERAZ, Sabrina ,  LEMERCIER, Isabelle ,  NOWAK, Elizabeth ,  LINES, Janet ,  WANG, Li ,  SPALLER, Mark

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K38/00 ,  A61K38/10 ,  G01N33/566 ,  C07K16/28 ,  C07K7/08

公开(公告)号：EP2864352B1

公开(公告)日：2018-08-08

申请号：EP13806673.3

申请日：2013-06-21

申请人： The Trustees Of Dartmouth College ,  King's College London

发明人： NOELLE, Randolph, J. ,  CEERAZ, Sabrina ,  LEMERCIER, Isabelle ,  NOWAK, Elizabeth ,  LINES, Janet, Louise

IPC分类号： C07K14/47 ,  C07K16/28 ,  C07K19/00 ,  A61K39/00 ,  A61P35/00 ,  A61P37/00 ,  A01K67/027 ,  A61K38/17 ,  C07K14/705 ,  C12N15/113

CPC分类号： C07K16/18 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0325 ,  A01K2267/0368 ,  A01K2267/0387 ,  A61K38/00 ,  A61K39/39 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/70503 ,  C07K14/70532 ,  C07K16/2827 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/735 ,  C12N15/1138 ,  C12N2310/14 ,  A61K31/00

摘要： The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease and type 1 or type 2 diabetes.

公开(公告)号：EP1067954A1

公开(公告)日：2001-01-17

申请号：EP99915237.4

申请日：1999-04-02

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： NOELLE, Randolph, J. ,  BURNS, Christopher, M.

IPC分类号： A61K38/17 ,  A61K39/395 ,  C07K14/52 ,  C07K14/525 ,  C07K16/18 ,  C07K16/28

CPC分类号： C07K16/2875 ,  A61K38/00

摘要： A method of treating lupus using anti-gp39 antibodies or fragments is provided. Such treatment has been shown to reverse disease, and in particular lupus-associated kidney disease, the major killer of lupus subjects.

公开(公告)号：EP0831906A1

公开(公告)日：1998-04-01

申请号：EP96921309.0

申请日：1996-06-06

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE ,  NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO

发明人： NOELLE, Randolph, J. ,  CLAASSEN, Eric

IPC分类号： C12P21 ,  A61K39 ,  A61K45 ,  A61P3 ,  A61P29 ,  A61P37 ,  C07K16 ,  A61K38 ,  C12R1

CPC分类号： C07K16/2875 ,  A61K38/00 ,  A61K2039/505

摘要： Method for the treatment of multiple sclerosis and other T cell mediated autoimmune disorders is described. The method involves administering to a subject a therapeutically effective amount of an antagonist of a receptor on a surface of a T cell which mediates contact dependent helper effector functions, for example, an anti-gp39 antibody.

公开(公告)号：EP4240409A1

公开(公告)日：2023-09-13

申请号：EP21890045.4

申请日：2021-11-04

申请人： The Trustees Of Dartmouth College

发明人： NOELLE, Randolph, J. ,  SMITS, Nicole

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K45/06 ,  A61P9/10 ,  A61P11/00

公开(公告)号：EP3442579A2

公开(公告)日：2019-02-20

申请号：EP17783330.8

申请日：2017-04-14

申请人： Immunext Inc. ,  The Trustees of Dartmouth College

发明人： MOLLOY, Michael ,  ROTHSTEIN, Jay ,  CARRIERE, Catherine ,  NOELLE, Randolph, J. ,  DELONG, Sabrina ,  LEMERCIER, Isabelle

IPC分类号： A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30

公开(公告)号：EP2864352A1

公开(公告)日：2015-04-29

申请号：EP13806673.3

申请日：2013-06-21

申请人： The Trustees Of Darthmouth College ,  King's College London

发明人： NOELLE, Randolph, J. ,  CEERAZ, Sabrina ,  LEMERCIER, Isabelle ,  NOWAK, Elizabeth ,  LINES, Janet, Louise

IPC分类号： C07K14/47 ,  C07K19/00 ,  A61K39/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/18 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0325 ,  A01K2267/0368 ,  A01K2267/0387 ,  A61K38/00 ,  A61K39/39 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/70503 ,  C07K14/70532 ,  C07K16/2827 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/735 ,  C12N15/1138 ,  C12N2310/14 ,  A61K31/00

摘要： The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides, multimeric VISTA polypeptides, VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn's disease, inflammatory bowel disease and type 1 or type 2 diabetes.

公开(公告)号：EP2892558A1

公开(公告)日：2015-07-15

申请号：EP13834707.5

申请日：2013-09-09

申请人： The Trustees Of Darthmouth College ,  King's College London

发明人： NOELLE, Randolph, J.

IPC分类号： A61K39/395 ,  A61K48/00 ,  A61P35/00

CPC分类号： A61K39/39566 ,  A61K35/17 ,  A61K39/0011 ,  A61K39/39 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2039/5152 ,  A61K2039/5256 ,  A61K2039/55516 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/32 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2710/10034 ,  C12N2710/10043 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/489 ,  A61K31/00

摘要： The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and compositions are able to antagonize the activity of VISTA, a naturally occurring “checkpoint” protein which contributes to immune tolerance, optionally in combination with an antagonist of a second checkpoint pathway such as PD-1. For example, such methods and compositions may be suitable for preventing and treating colon cancer or another cancer. An exemplary VISTA antagonist, specifically, an anti-VISTA antibody, is demonstrated herein to activate an immune response against cancer cells in vitro and in vivo, thereby conferring protective anti-tumor immunity which decreased tumor burden. Additionally, an additive benefit was observed when a VISTA antagonist was used in combination with a second checkpoint protein antagonist, specifically, an antibody against PD-1 ligand (PD-L1).

摘要翻译： 本公开涉及用于在有需要的患者中激活免疫应答的组合物和治疗方法。 在优选的实施方案中，本发明的方法和组合物能够拮抗VISTA的活性，VISTA是有助于免疫耐受的天然存在的“检查点”蛋白质，任选地与第二检查点途径的拮抗剂如PD-1组合。 例如，这样的方法和组合物可适用于预防和治疗结肠癌或其它癌症。 在本文中证明了示例性的VISTA拮抗剂，特别是抗-VISTA抗体，以在体外和体内激活针对癌细胞的免疫应答，由此赋予降低肿瘤负荷的保护性抗肿瘤免疫性。 另外，当将VISTA拮抗剂与第二检查点蛋白拮抗剂，特别是针对PD-1配体（PD-L1）的抗体组合使用时，观察到附加益处。