-
公开(公告)号：EP4149519A1
公开(公告)日：2023-03-22
申请号：EP21804731.4
申请日：2021-05-14
-
2.发明授权
公开(公告)号：EP2252313B1
公开(公告)日：2015-04-08
申请号：EP09710178.6
申请日：2009-02-12
IPC分类号： A61K38/00
CPC分类号： A61K31/445 , C07K14/00 , C12Q1/34 , G01N33/6893 , G01N2333/47 , G01N2333/94 , G01N2800/38 , G01N2800/52
-
3.发明授权UTILIZATION OF PHARMACOLOGICAL CHAPERONES TO IMPROVE MANUFACTURING AND PURIFICATION OF ACID BETA-GLUCOSIDASE 有权使用的药物分子伴侣提高了生产和清洁酸性β-葡萄糖苷
公开(公告)号：EP2435459B1
公开(公告)日：2016-05-04
申请号：EP10781143.2
申请日：2010-05-26
发明人： DO, Hung, V.
CPC分类号： C07D201/00 , C12N9/2402 , C12N9/96 , C12P21/02
-
4.发明公开TREATMENT OF POMPE DISEASE WITH SPECIFIC PHARMACOLOGICAL CHAPERONES AND MONITORING TREATMENT USING SURROGATE MARKERS 审中-公开治疗克罗恩热泵在某些药理伴侣监测和治疗的替代指标
公开(公告)号：EP2252325A2
公开(公告)日：2010-11-24
申请号：EP09720946.4
申请日：2009-03-12
发明人： WUSTMAN, Brandon , DO, Hung, V.
IPC分类号： A61K38/47
CPC分类号： G01N33/6893 , G01N33/5091 , G01N2333/49 , G01N2333/515 , G01N2333/5412 , G01N2333/5418 , G01N2333/5421 , G01N2800/042 , G01N2800/52
摘要： Provided is a method of monitoring the treatment of Pompe disease with specific pharmacological chaperones using systemic and/or cellular surrogate markers.
-
5.发明公开
公开(公告)号：EP2260107A2
公开(公告)日：2010-12-15
申请号：EP09720341.8
申请日：2009-03-12
发明人： WUSTMAN, Brandon , DO, Hung, V.
IPC分类号： C12Q1/00
CPC分类号： G01N33/6893 , G01N2333/928 , G01N2800/042 , G01N2800/52
摘要： Provided are in vitro, ex vivo and in vivo methods for determining whether a patient with Pompe disease will respond to treatment with a specific pharmacological chaperone.
-
6.发明公开UTILIZATION OF PHARMACOLOGICAL CHAPERONES TO IMPROVE MANUFACTURING AND PURIFICATION OF BIOLOGICS 有权使用的药物分子伴侣提高了生产和清洁酸性β-葡萄糖苷
公开(公告)号：EP2435459A1
公开(公告)日：2012-04-04
申请号：EP10781143.2
申请日：2010-05-26
发明人： DO, Hung, V.
CPC分类号： C07D201/00 , C12N9/2402 , C12N9/96 , C12P21/02
摘要： The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of the protein out of the cell's endoplasmic reticulum, and increase secretion of the protein by the cell.
-
7.发明公开METHOD TO PREDICT RESPONSE TO PHARMACOLOGICAL CHAPERONE TREATMENT OF DISEASES 有权一种用于预测与药理伴侣疾病的治疗的反应
公开(公告)号：EP2252313A2
公开(公告)日：2010-11-24
申请号：EP09710178.6
申请日：2009-02-12
IPC分类号： A61K38/00
CPC分类号： A61K31/445 , C07K14/00 , C12Q1/34 , G01N33/6893 , G01N2333/47 , G01N2333/94 , G01N2800/38 , G01N2800/52
摘要： The present invention provides methods to determine whether a patient with a lysosomal storage disorder will benefit from treatment with a specific pharmacological chaperone. The present invention exemplifies an in vitro method for determining α-galactosidase A responsiveness to a pharmacological chaperone such as 1-deoxygalactonojirimycin in a cell line expressing a mutant from of α- galactosidase A. The invention also provides a method for diagnosing Fabry disease in patients suspected of having Fabry disease.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.014 秒)
