公开(公告)号：EP2435459A4

公开(公告)日：2014-01-15

申请号：EP10781143

申请日：2010-05-26

Applicant: AMICUS THERAPEUTICS INC

Inventor： DO HUNG V

IPC: C07H17/02 ,  C07H15/00 ,  C12N1/00 ,  C12N5/10 ,  C12N11/14 ,  C12P7/06 ,  C12R1/645

CPC classification number: C07D201/00 ,  C12N9/2402 ,  C12N9/96 ,  C12P21/02

公开(公告)号：EP2361009A4

公开(公告)日：2012-12-05

申请号：EP09835752

申请日：2009-12-22

Applicant: DU PONT

Inventor： HERRON NORMAN ,  GUIDRY MARK A ,  ROSTOVTSEV VSEVOLOD ,  GAO WEIYING ,  WANG YING ,  SHEN YULONG ,  MERLO JEFFREY A

IPC: C07D471/04 ,  C07D471/16 ,  H01L51/50

CPC classification number: C07D471/04 ,  C07D201/00 ,  C07D471/16 ,  H01L51/0061 ,  H01L51/0072 ,  H01L51/5012 ,  H01L51/5024 ,  H01L51/5052 ,  H01L51/5072 ,  H01L2251/5384

公开(公告)号：EP2435459B1

公开(公告)日：2016-05-04

申请号：EP10781143.2

申请日：2010-05-26

Applicant: Amicus Therapeutics, Inc.

Inventor： DO, Hung, V.

IPC: C12N9/96 ,  C12P21/02

CPC classification number: C07D201/00 ,  C12N9/2402 ,  C12N9/96 ,  C12P21/02

公开(公告)号：EP2148856A2

公开(公告)日：2010-02-03

申请号：EP08725798.6

申请日：2008-02-20

Applicant: Board of Trustees of Michigan State University

Inventor： FROST, John W.

IPC: C07D201/00 ,  C07D201/02 ,  C07D201/08

CPC classification number: C07D201/00 ,  C07D201/02 ,  C07D201/08 ,  Y02P20/52

Abstract: Catalytic processes for preparing caprolactam, pipecolinic acid, and their derivatives, from lysine or alpha-amino-epsilon-caprolactam starting materials, and products produced thereby. A process for preparing caprolactam or a derivative thereof, the process comprising contacting a reactant comprising lysine or alpha aminocaprolactam with a catalyst and a gas comprising hydrogen gas, in the presence of a solvent. The catalyst may be provided on a support material, such as a transition metal.

公开(公告)号：EP3892624B1

公开(公告)日：2024-09-25

申请号：EP20795353.0

申请日：2020-04-24

IPC: C07F7/00 ,  C08F4/62 ,  C08F4/619 ,  C08F4/659 ,  C08F4/52 ,  C07D213/38 ,  C07F7/08 ,  C08F210/16

CPC classification number: C07F7/00 ,  C07F7/0816 ,  C07F7/0814 ,  C07D201/00 ,  C08F210/16 ,  C08F4/65912 ,  C08F4/65908 ,  C07D213/38

公开(公告)号：EP2958562A1

公开(公告)日：2015-12-30

申请号：EP14754282.3

申请日：2014-02-20

Applicant: Merck Sharp & Dohme Corp.

Inventor： BROCKUNIER, Linda L. ,  CHEN, Helen ,  CHOBANIAN, Harry R. ,  CLEMENTS, Matthew J. ,  CRESPO, Alejandro ,  DEMONG, Duane E. ,  GUO, Yan ,  HAGMANN, William K. ,  MARCANTONIO, Karen M. ,  MILLER, Michael ,  PIO, Barbara ,  PLUMMER, Christopher W. ,  XIAO, Dong

IPC: A61K31/357

CPC classification number: C07D493/04 ,  A61K31/352 ,  A61K31/416 ,  A61K31/422 ,  A61K31/427 ,  A61K31/436 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/497 ,  A61K31/538 ,  A61K45/06 ,  C07D201/00 ,  C07D311/04 ,  C07D311/28 ,  C07D319/20 ,  C07D405/04 ,  C07D405/06 ,  C07D405/10 ,  C07D405/14 ,  C07D413/10 ,  C07D417/04 ,  C07D491/048 ,  C07D491/052

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

公开(公告)号：EP2669967A1

公开(公告)日：2013-12-04

申请号：EP13169774.0

申请日：2009-12-22

Applicant: E. I. du Pont de Nemours and Company

Inventor： Herron, Norman ,  Guidry, Mark A. ,  Rostovtsev, Vsevolod ,  Gao, Weiying ,  Wang, Ying ,  Shen, Yulong ,  Merlo, Jeffrey A.

IPC: H01L51/50 ,  C07D471/04 ,  C07D471/16

CPC classification number: C07D471/04 ,  C07D201/00 ,  C07D471/16 ,  H01L51/0061 ,  H01L51/0072 ,  H01L51/5012 ,  H01L51/5024 ,  H01L51/5052 ,  H01L51/5072 ,  H01L2251/5384

Abstract: There is provided an organic electronic device having an anode, a hole injection layer, a photoactive layer, an electron transport layer, and a cathode. At least one of the photoactive layer and the electron transport layer includes a compound having Formula I where: R1 is the same or different and can be naphthyl, naphthylphenyl, triphenylamino, or carbazolylphenyl; and one of the following conditions is met: (i) R2= R3 and is biphenyl, naphthyl, naphthylphenyl, arylanthracenyl, phenanthryl, triphenylamino, or carbazolylphenyl; or (ii) R2 is H or phenyl; and R3 is phenyl, biphenyl, naphthyl, naphthylphenyl, arylanthracenyl, phenanthryl, triphenylamino, and carbazolylphenyl.

Abstract translation: 提供了具有阳极，空穴注入层，光活性层，电子传输层和阴极的有机电子器件。 光活性层和电子传输层中的至少一个包括具有式I的化合物，其中：R 1相同或不同，可以是萘基，萘基苯基，三苯基氨基或咔唑基苯基; 满足下列条件之一：（i）R2 = R3，为联苯基，萘基，萘基苯基，芳基蒽基，菲基，三苯基氨基或咔唑基苯基; 或（ii）R 2为H或苯基; 联苯基，萘基，萘基苯基，芳基蒽基，菲基，三苯基氨基和咔唑基苯基。

公开(公告)号：EP3099304B1

公开(公告)日：2024-07-17

申请号：EP15743644.5

申请日：2015-01-30

IPC: A61K31/549 ,  A61K9/02 ,  A61P27/06 ,  A61K31/353 ,  A61K31/675 ,  C07F9/6547 ,  C07F9/6558 ,  C07D405/04 ,  C07D405/12 ,  C07D285/24

CPC classification number: A61K31/549 ,  A61K9/00 ,  A61K31/4025 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/675 ,  C07D201/00 ,  C07D405/04 ,  C07D405/12 ,  C07D285/24 ,  A61K9/0048 ,  A61K9/0051 ,  A61K31/353 ,  C07D311/20 ,  C07D311/70 ,  C07D405/14 ,  A61P27/06

公开(公告)号：EP2148856B1

公开(公告)日：2015-09-02

申请号：EP08725798.6

申请日：2008-02-20

Applicant: Board of Trustees of Michigan State University

Inventor： FROST, John W.

IPC: C07D201/00 ,  C07D201/02 ,  C07D201/08

CPC classification number: C07D201/00 ,  C07D201/02 ,  C07D201/08 ,  Y02P20/52

公开(公告)号：EP2435459A1

公开(公告)日：2012-04-04

申请号：EP10781143.2

申请日：2010-05-26

Applicant: Amicus Therapeutics, Inc.

Inventor： DO, Hung, V.

IPC: C07H17/02 ,  C07H15/00 ,  C12N5/10

CPC classification number: C07D201/00 ,  C12N9/2402 ,  C12N9/96 ,  C12P21/02

Abstract: The present invention provides methods for improving the production of recombinant proteins through the use of pharmacological chaperones for the recombinant proteins. As exemplified by the present invention, the binding of a pharmacological chaperone to a recombinant protein expressed by a cell can stabilize the protein and increase export of the protein out of the cell's endoplasmic reticulum, and increase secretion of the protein by the cell.